This book draws a colorful and widespread picture of global affine hypersurface theory up to the most recent state. Moreover, the recent development revealed that affine differential geometry - as differential geometry in general - has an exciting intersection area with other fields of interest, like partial differential equations, global analysis, convex geometry and Riemann surfaces. The second edition of this monograph leads the reader from introductory concepts to recent research. Since the publication of the first edition in 1993 there appeared important new contributions, like the solutions of two different affine Bernstein conjectures, due to Chern and Calabi, respectively. Moreover, a large subclass of hyperbolic affine spheres were classified in recent years, namely the locally strongly convex Blaschke hypersurfaces that have parallel cubic form with respect to the Levi-Civita connection of the Blaschke metric. The authors of this book present such results and new methods of proof.

This book describes the mineralization process of barite-fluorite deposits in southeastern Sichuan, Yangtze Block, China. Mainly through systematic field geological surveys and detailed indoor research work, the typical barite-fluorite deposits in this area were analyzed using a variety of analysis methods such as single fluid inclusion LA-ICP-MS composition analysis, trace rare earth element analysis, H-O-S-Sr isotope analysis, F element content analysis, and Sm-Nd geochronological analysis. By in-depth analysis of the ore-forming environment, mineralization process and geological characteristics of barite-fluorite deposits, the following were determined: (1) the source of ore-forming fluids of barite-fluorite deposits and (2) the migration, concentration, enrichment, and evolution of ore-forming sources, exploring the formation mechanism of barite-fluorite deposits. Summarizing the mineralization regularity of the deposit in this area of China provides a new insight and basis for the study of similar types of deposits in the world.

Min Li and a panel of hands-on experimentalists detail state-of-the-art molecular techniques for studying NMDA ligand-gated ion channels and developing assays for nontherapeutic lead selection. The topics range from cDNA cloning to in vitro and in vivo investigation of the channel complex in the mammalian brain. Additional topics include the biochemical analysis of the channel protein and the construction of various heterologous systems for both basic research and high throughput screens (HTS) for pharmaceutical chemicals. Although the focus is on NMDA receptors, the methods are applicable to other ligand-gated ion channels and with some modification may be extended to related membrane signaling receptors. NMDA Receptor Protocols offers today's scientists powerful methods for basic research on NMDA receptor structure and function, as well as enormous opportunities for clinical investigation toward the development of novel bioactive compounds.

This book represents a new and hopeful paradigm for treatment of diseases that are spreading globally as countries adopt Western lifestyles and standards of living. It describes the phenomenal science and clinical efficacy of the work of Dr Xiu-Min Li across a broad array of immune and inflammatory diseases. These include food allergies, asthma, eczema, 'new' diseases such as mast cell disorders, obesity, and mental health problems that are part of a worldwide 'epidemic of progress'.The most allergic people are caught in a cycle of medication, steroid dependency, emergency hospitalization, and curtailing their activities and diets to avoid triggers. Children are 'losing their childhoods.' They are fighting a battle against diet, climate change, and environmental degradation. Dr Li offers them hope by healing the entire immune system, not just address symptoms. In her practice Dr Li treats complex combinations of allergic diseases for all ages, from infancy through adulthood, bringing relief to people who have suffered terribly from oozing, bleeding skin, desperate breathing disorders, and life-threatening food allergies. She uses her vast knowledge of biochemistry to improve on the traditional decoctions to create refined versions suitable for modern tastes and lifestyles. In contrast with Western pharmaceuticals, which are the study of 'one molecule's effects on one other molecule' Dr Li's work shows the effects of multiple molecules on multiple other molecules. Increasing numbers of scientists are beginning to see the possibilities for their own research, with the prospects for more collaborations with prestigious institutions around the world. allergyblogawardsuk.co.uk/5-managing-asthma-allergies-with-henry-erlich/

This book represents a new and hopeful paradigm for treatment of diseases that are spreading globally as countries adopt Western lifestyles and standards of living. It describes the phenomenal science and clinical efficacy of the work of Dr Xiu-Min Li across a broad array of immune and inflammatory diseases. These include food allergies, asthma, eczema, 'new' diseases such as mast cell disorders, obesity, and mental health problems that are part of a worldwide 'epidemic of progress'.The most allergic people are caught in a cycle of medication, steroid dependency, emergency hospitalization, and curtailing their activities and diets to avoid triggers. Children are 'losing their childhoods.' They are fighting a battle against diet, climate change, and environmental degradation. Dr Li offers them hope by healing the entire immune system, not just address symptoms. In her practice Dr Li treats complex combinations of allergic diseases for all ages, from infancy through adulthood, bringing relief to people who have suffered terribly from oozing, bleeding skin, desperate breathing disorders, and life-threatening food allergies. She uses her vast knowledge of biochemistry to improve on the traditional decoctions to create refined versions suitable for modern tastes and lifestyles. In contrast with Western pharmaceuticals, which are the study of 'one molecule's effects on one other molecule' Dr Li's work shows the effects of multiple molecules on multiple other molecules. Increasing numbers of scientists are beginning to see the possibilities for their own research, with the prospects for more collaborations with prestigious institutions around the world. allergyblogawardsuk.co.uk/5-managing-asthma-allergies-with-henry-erlich/

This two volume set (CCIS 727 and 728) constitutes the refereed proceedings of the Third International Conference of Pioneering Computer Scientists, Engineers and Educators, ICPCSEE 2017 (originally ICYCSEE) held in Changsha, China, in September 2017. The 112 revised full papers presented in these two volumes were carefully reviewed and selected from 987 submissions. The papers cover a wide range of topics related to Basic Theory and Techniques for Data Science including Mathematical Issues in Data Science, Computational Theory for Data Science, Big Data Management and Applications, Data Quality and Data Preparation, Evaluation and Measurement in Data Science, Data Visualization, Big Data Mining and Knowledge Management, Infrastructure for Data Science, Machine Learning for Data Science, Data Security and Privacy, Applications of Data Science, Case Study of Data Science, Multimedia Data Management and Analysis, Data-driven Scientific Research, Data-driven Bioinformatics, Data-driven Healthcare, Data-driven Management, Data-driven eGovernment, Data-driven Smart City/Planet, Data Marketing and Economics, Social Media and Recommendation Systems, Data-driven Security, Data-driven Business Model Innovation, Social and/or organizational impacts of Data Science.

In this book, Li Min proposes a new paradigm for the foundation and emergence of the classical tradition in early China, from the late Neolithic through the Zhou period. Using a wide range of historical and archaeological data, he explains the development of ritual authority and particular concepts of kingship over time in relation to social memory. His volume weaves together the major benchmarks in the emergence of the classical tradition, particularly how legacies of prehistoric interregional interactions, state formation, urban florescence and collapse during the late third and the second millenniums BCE laid the critical foundation for the Sandai notion of history among Zhou elite. Moreover, the literary-historical accounts of the legendary Xia Dynasty in early China reveal a cultural construction involving social memories of the past and subsequent political elaborations in various phases of history. This volume enables a new understanding on the long-term processes that enabled a classical civilization in China to take shape.

Min Li and a panel of hands-on experimentalists detail state-of-the-art molecular techniques for studying NMDA ligand-gated ion channels and developing assays for nontherapeutic lead selection. The topics range from cDNA cloning to in vitro and in vivo investigation of the channel complex in the mammalian brain. Additional topics include the biochemical analysis of the channel protein and the construction of various heterologous systems for both basic research and high throughput screens (HTS) for pharmaceutical chemicals. Although the focus is on NMDA receptors, the methods are applicable to other ligand-gated ion channels and with some modification may be extended to related membrane signaling receptors. NMDA Receptor Protocols offers today's scientists powerful methods for basic research on NMDA receptor structure and function, as well as enormous opportunities for clinical investigation toward the development of novel bioactive compounds.

'It was August 1, a time when New York children are generally wearing shorts and short-sleeved shirts. My first patient was 18 months old and dressed more appropriately for late fall. When we took off his clothes I saw why. He was covered head-to-toe with oozing, staph-infected lesions, which he promptly began to scratch. That explained the overdressing - it was the only deterrent to scratching ... I had expected quick resolution using oral medication-teas - based on my experience in China. I wasn't prepared for this level of severity.'Dr Xiu-Min LiThus began Dr Li's journey into the treatment of eczema in the United States, which afflicts some 15-20% of children and 10% of adults. This book represents years of collaboration with patients, parents, pediatricians, allergists and dermatologists to treat disorders that resist standard intervention, and in some cases are caused by conventional treatment in the form of topical corticosteroids. Chronic use of steroids by patients desperate for relief from itching, oozing and scaling, and subsequent withdrawal can result in severe physical and psychological symptoms.'It wasn't just the extent of the disease. It was also the toll it took on family quality of life. Kids were crying. Mothers were crying. They were all sleeping badly. Most of these families also had bad food allergies, but food allergy is a silent disease. People worry about it, but with eczema they suffer every day.'Dr LiThis is a book of scholarship. Dr Li, explores the literature of traditional Chinese medicine, which has a long history of describing and treating skin disorders, to find therapies that might benefit current patients. It is a book of science as Dr Li and her team use state-of-the-art technology to explore the mechanisms of disease, the therapeutic effects of the herbs, and ways to make them more effective. But it is also a book of compassion as patients and their families recount their experience of illness and the road back, after working with Dr Li's private practice.Dr Li has dual professorships in Pathology, Microbiology & Immunology, and Otolaryngology at New York Medical College. Dr Li and her team have long devoted to themselves to developing novel therapies for food allergy, asthma, eczema, Eosinophilic Esophagitis, and Crohn's disease, among other inflammatory conditions.

This book describes the mineralization process of barite-fluorite deposits in southeastern Sichuan, Yangtze Block, China. Mainly through systematic field geological surveys and detailed indoor research work, the typical barite-fluorite deposits in this area were analyzed using a variety of analysis methods such as single fluid inclusion LA-ICP-MS composition analysis, trace rare earth element analysis, H-O-S-Sr isotope analysis, F element content analysis, and Sm-Nd geochronological analysis. By in-depth analysis of the ore-forming environment, mineralization process and geological characteristics of barite-fluorite deposits, the following were determined: (1) the source of ore-forming fluids of barite-fluorite deposits and (2) the migration, concentration, enrichment, and evolution of ore-forming sources, exploring the formation mechanism of barite-fluorite deposits. Summarizing the mineralization regularity of the deposit in this area of China provides a new insight and basis for the study of similar types of deposits in the world.

This book constitutes the proceedings of the 24th International Conference on Theory and Applications of Satisfiability Testing, SAT 2021, which took place in Barcelona, Spain, in July 2021.The 37 full papers presented in this volume were carefully reviewed and selected from 73 submissions. They deal with theory and applications of the propositional satisfiability problem, broadly construed. Aside from plain propositional satisfiability, the scope of the meeting includes Boolean optimization, including MaxSAT and pseudo-Boolean (PB) constraints, quantified Boolean formulas (QBF), satisfiability modulo theories (SMT), and constraint programming (CP) for problems with clear connections to Boolean reasoning.

This book constitutes the proceedings of the 17th International Symposium on Bioinformatics Research and Applications, ISBRA 2021, held in Shenzhen, China, in November 2021. The 51 full papers presented in this book were carefully reviewed and selected from 135 submissions. They were organized in topical sections named: AI and disease; computational proteomics; biomedical imaging; drug screening and drug-drug interaction prediction; Biomedical data; sequencing data analysis.

This book constitutes the proceedings of the 15th International Symposium on Bioinformatics Research and Applications, ISBRA 2019, held in Barcelona, Spain, in June 2019. The 22 full papers presented in this book were carefully reviewed and selected from 95 submissions. They were organized in topical sections named: genome analysis; systems biology; computational proteomics; machine and deep learning; and data analysis and methodology.

This book constitutes the proceedings of the 13th International Symposium on Bioinformatics Research and Applications, ISBRA 2017, held in Honolulu, HI, USA, in May/June 2017. The 27 full papers presented together with 18 short papers and 24 invited abstracts were carefully reviewed and selected from 131 submissions. They cover topics such as: biomarker discovery; biomedical databases and data integration; biomedical text mining and ortologies; biomolecular imaging; comparative genomics; computational genetic epidemiology; computational proteomics; data mining and visualization; gene expression analysis; genome analysis; high-performance bio-computing; metagenomics; molecular evolution; molecular modelling and simulation; next-generation sequencing data analysis; pattern discovery and classification; population genetics; software tools and applications; structural biology; and systems biology.

Aesthetic Surgery of the Craniofacial Skeleton is a unique atlas presenting specific procedures for aesthetic craniofacial surgery in a comprehensive and easily understandable style. With over 190 fine line drawings specially created for this volume, this book will have multifaceted applications; as an operation manual for the aesthetic craniofacial surgeon, a reference source for the general plastic surgeon, and as an introductory text for residents in craniofacial, reconstructive, oral, head and neck surgery. It includes close to 100 osteotomy methods and imperative information on patient selection, preoperative procedures, complications and implants.

'It was August 1, a time when New York children are generally wearing shorts and short-sleeved shirts. My first patient was 18 months old and dressed more appropriately for late fall. When we took off his clothes I saw why. He was covered head-to-toe with oozing, staph-infected lesions, which he promptly began to scratch. That explained the overdressing - it was the only deterrent to scratching ... I had expected quick resolution using oral medication-teas - based on my experience in China. I wasn't prepared for this level of severity.'Dr Xiu-Min LiThus began Dr Li's journey into the treatment of eczema in the United States, which afflicts some 15-20% of children and 10% of adults. This book represents years of collaboration with patients, parents, pediatricians, allergists and dermatologists to treat disorders that resist standard intervention, and in some cases are caused by conventional treatment in the form of topical corticosteroids. Chronic use of steroids by patients desperate for relief from itching, oozing and scaling, and subsequent withdrawal can result in severe physical and psychological symptoms.'It wasn't just the extent of the disease. It was also the toll it took on family quality of life. Kids were crying. Mothers were crying. They were all sleeping badly. Most of these families also had bad food allergies, but food allergy is a silent disease. People worry about it, but with eczema they suffer every day.'Dr LiThis is a book of scholarship. Dr Li, explores the literature of traditional Chinese medicine, which has a long history of describing and treating skin disorders, to find therapies that might benefit current patients. It is a book of science as Dr Li and her team use state-of-the-art technology to explore the mechanisms of disease, the therapeutic effects of the herbs, and ways to make them more effective. But it is also a book of compassion as patients and their families recount their experience of illness and the road back, after working with Dr Li's private practice.Dr Li has dual professorships in Pathology, Microbiology & Immunology, and Otolaryngology at New York Medical College. Dr Li and her team have long devoted to themselves to developing novel therapies for food allergy, asthma, eczema, Eosinophilic Esophagitis, and Crohn's disease, among other inflammatory conditions.

The vast majority of drugs are organic molecular entities. A clear understanding of the organic chemistry of drug degradation is essential to maintaining the stability, efficacy, and safety of a drug product throughout its shelf-life. During analytical method development, stability testing, and pharmaceutical manufacturing troubleshooting activities, one of the frequently occurring and usually challenging events would be the identification of drug degradants and understanding of drug degradation mechanisms and pathways. This book is written by a veteran of the pharmaceutical industry who has first-hand experience in drug design and development, drug degradation mechanism studies, analytical development, and manufacturing process troubleshooting and improvement. The author discusses various degradation pathways with an emphasis on the mechanisms of the underlying organic chemistry, which should aid greatly in the efforts of degradant identification, formulation development, analytical development, and manufacturing process improvement. Organic reactions that are significant in drug degradation will first be reviewed and then illustrated by examples of drug degradation reported in the literature. The author brings the book to a close with a final chapter dedicated to the strategy for rapid elucidation of drug degradants with regard to the current regulatory requirements and guidelines. One chapter that should be given special attention is Chapter 3, Oxidative Degradation. Oxidative degradation is one of the most common degradation pathways but perhaps the most complex one. This chapter employs more than sixty drug degradation case studies with in-depth discussion in regard to their unique degradation pathways. With the increasing regulatory requirements on the quality and safety of pharmaceutical products, in particular with regard to drug impurities and degradants, the book will be an invaluable resource for pharmaceutical and analytical scientists who engage in formulation development, analytical development, stability studies, degradant identification, and support of manufacturing process improvement. In addition, it will also be helpful to scientists engaged in drug discovery and development as well as in drug metabolism studies.