This book provides in-depth description, explanation, and discussion of goal frustration. It brings together a repertoire of perspectives and strategies that educators and scholars from diverse educational contexts have conceptualized and/or implemented in order to monitor, control, or overcome the occurrence of frustration. This book describes the new technologies can be applied in the conceptualization and operationalization of goal frustration. It also discusses the strategies and pedagogies we can use to cope with this emotion. This book offers evidence-based reports of goal frustration as well as data-driven approaches by presenting both theoretical account and empirical evidence that are grounded in educational and psychological research. This work will appeal to a wider readership from practitioners, parents, to educational researchers.

This book provides a timely review of the role of histone modifications in epigenetic control of gene expression. Topics covered include: basic mechanisms of molecular recognition of histone post-translational modification (PTMs); combinatorial readout of histone PTMs by tandem epigenome reader domains; genome-wide profiling of histone PTM interactions; small molecule modulation of histone PTM interactions and their potential as a new approach to therapeutic intervention in human diseases. All chapters were written by leading scientists who made the original key discoveries of the structure and mechanism of evolutionarily conserved reader domains, which serve to direct gene transcription in chromatin through interactions with DNA-packing histones in a PTM-sensitive manner.

This book provides a timely review of the role of histone modifications in epigenetic control of gene expression. Topics covered include: basic mechanisms of molecular recognition of histone post-translational modification (PTMs); combinatorial readout of histone PTMs by tandem epigenome reader domains; genome-wide profiling of histone PTM interactions; small molecule modulation of histone PTM interactions and their potential as a new approach to therapeutic intervention in human diseases. All chapters were written by leading scientists who made the original key discoveries of the structure and mechanism of evolutionarily conserved reader domains, which serve to direct gene transcription in chromatin through interactions with DNA-packing histones in a PTM-sensitive manner.