Histone Recognition (Paperback, Softcover reprint of the original 1st ed. 2015)

This book provides a timely review of the role of histone modifications in epigenetic control of gene expression. Topics covered include: basic mechanisms of molecular recognition of histone post-translational modification (PTMs); combinatorial readout of histone PTMs by tandem epigenome reader domains; genome-wide profiling of histone PTM interactions; small molecule modulation of histone PTM interactions and their potential as a new approach to therapeutic intervention in human diseases. All chapters were written by leading scientists who made the original key discoveries of the structure and mechanism of evolutionarily conserved reader domains, which serve to direct gene transcription in chromatin through interactions with DNA-packing histones in a PTM-sensitive manner.

General

Imprint:	Springer International Publishing AG
Country of origin:	Switzerland
Release date:	October 2016
First published:	2015
Editors:	Ming-Ming Zhou
Dimensions:	235 x 155 x 15mm (L x W x T)
Format:	Paperback
Pages:	282
Edition:	Softcover reprint of the original 1st ed. 2015
ISBN-13:	978-3-319-37666-0
Categories:	Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins Promotions
LSN:	3-319-37666-7
Barcode:	9783319376660

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