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The crude methanolic extract and different fractions of plant
Boerhavia repens were subjected to a number of biological tests for
the evaluation of their pharmacological activity.The whole plant of
Boerhavia repens was extracted with methanol by cold extraction
method. The concentrated extract of the plant were then partitioned
into pet ether, carbon tetrachloride, dichloromethane and ethyl
acetate soluble fractions.The carbon tetrachloride, dichloromethane
and the ethyl acetate soluble fractions of the plant showed strong
anti-oxidant activity. The cytotoxicity evaluation of the plant
extracts were carried out by Brine Shrimp Lethality Bioassay. The
pet ether soluble fractions of the plant showed strong cytotoxic
activity. The crude methanolic extract and pet ether soluble
fraction at doses of 400 mg/kg exhibited strong analgesic activity,
anti-inflammatory and anti-pyretic activity. The different
fractions and the crude methanolic extract were also subjected to
anti-microbial assay. However no fractions exhibited strong
anti-microbial activity.
Medicinal plants are important source to be explored for the
discovery and development of newer, safer and effective drug
candidates. In medicinal plants research, bioactivity guided
phytochemical research can be considered as a rational approach.
The ethanopharmacological investigations of the study plant
Schoenoplectus grossus was carried out for the first time ever in
research lab by Professor Dr. Rahman's research group. The powdered
root of this plant was extracted with methanol and fractioned by
modified Kupchan partitioning method to provide petroleum ether,
carbon tetrachloride, dichloromethane, and ethyl acetate soluble
fractions. All fractions and methanol extract were investigated for
pharmacological activities on animal model. The analgesic,
antipyretic, anti-inflammatory, antihelmintic, and antidiarrheal
effects were analyzed on dose dependent manner by comparing with
standard reference drug. The extract was also screened out for
cytotoxic, antioxidant, and thrombolytic activity by in vitro
methods.
Polypharmacy practices are very common in psychiatry specially in
Bangladesh.Psychiatric patients receive multiple drugs in order to
have their therapeutic recovery. Both typical and atypical
antipsychotic drugs are frequently prescribed by the psychiatrists.
Use of multiple antipsychotic molecules may exert some sort of
synergistic efficacy but cause a lot of unwanted side effects in
the long run. Such a practice can adversely affect the quality of
life of the corresponding patients. More rational use of
antipsychotic drug should practiced in psychiatry with a view to
ensuring quality of life of the psychiatric patients. Atypical
antipsychotic drugs are new generation drugs and more safe for use.
Besides atypical antipsychotic drugs sometimes offer some unique
benefits which make them unparalleled choice.Appropriate drug
should be chosen depending on the disease condition and overall
benefits of the patients. Unnecessary any molecules' use should be
discouraged so that adverse effects or metabolic side effects can
be minimized to the least content. In this way we can expect better
quality of life along with stabilized psychiatric patients.
The study was designed for phytochemical investigations of
ethanolic extract of bark and leaf of Swietenia mahagoni belonging
to the family of Meliaceae and evaluation of their biological
activities with the special emphasis on analgesic,
anti-inflammatory, anti-microbial and cytotoxic screening in
different animal model. Phytochemical investigations were done by
extensive analysis with high resolution proton NMR spectroscopic
data. The ethanol extract of stem bark was partitioned between
pet-ether, dichloromethane and methanol fractions. Chromatographic
isolation of dichloromethane fraction using column chromatography
followed by preparative TLC afforded tetranortriterpenoid compound.
Ethanol extract and different fractions showed significant
analgesic and anti-inflammatory potential.From the bio-assay of
different fractions and extract, significant cytotoxic properties
were evaluated whereas mild to moderate antimicrobial activity was
found in this study.
Pterospermum acerifolium belonging to the family of Sterculiaceae
has been studied. The work was carried out for isolation of it's
secondary metabolites and evaluation of biological activities of
it's bark with special emphasis on antioxidant activity,
cytotoxicity, and antimicrobial activity The isolated compounds
were identified by extensive analyses of their high resolution
proton-NMR spectroscopic data.
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