This book is a collective work published as part of a larger project entitled "Mexico-Guatemala cross-border region; regional dimensions and bases for integrated development," the purpose of which is to introduce a series of issues relative to the geopolitical dimension of Mexico's actions in Central America and its stance on conflicts in the region between 1959 and 2019. The most widely published texts up until now have been written by Mexican authors, and we have less insight into how these processes have been viewed from Central America. With that in mind, we brought together a group of specialists, each highly renowned in their own country, some of them academics and others whose accounts are worth hearing because of their participation in social and political movements that are closely bound up in this issue. The following questions guided the drafting of this book: how have Central Americans viewed Mexican policies toward their countries? What do they think of Mexico's influence in various spheres of life in the region? Has Central America's past view of Mexico as their Latin American "big brother" changed? What do they consider to be the most salient issues in relations between our countries? What were the strategic interests of Cuba and the United States in the region? How did these processes develop during the Cold War, and what elements began to change in the 1990s? The papers collected here seek to answer these questions and to bring together and share knowledge and perspectives. This book will appeal to students and researchers alike interested in the politics and history of 20th century Mexico and Central America, as well as the involvement of such states during the Cold War and thereafter.