The book provides a holistic approach to wine destination management and marketing by bringing together wine tourism research with research in wine and destination management. Chapters are contributed by numerous international authors offering an international and multidisciplinary perspective. The book combines fresh research approaches with international industry examples and case studies in the following key topics: understanding demand of wine destinations; New approaches and practices of wine destination marketing; innovation and design of wine destination experiences and wine routes; planning and development of wine destinations. The book analyses wine destination management and marketing issues from the perspectives of the various stakeholders of wine destinations (e.g. tourists, cellar doors, wine tourism firms, destination managers, wine associations and networks). The book is equally valuable to researchers and industry professionals alike.

This edited work presents a unique and authoritative look at morality - its development within the individual, its evolution within society, and its place within the law. The contributors represent some of the foremost authorities in these fields, and the book represents a collection of essays presented at a symposium on social constructivism and morality.

This is a concise commentary on Kant's aims and arguments in his celebrated "First Critique", within the context of the dominant schools of philosophy of his time. "How is Nature Possible?: Kant's Project in the First Critique" presents a clear and systematic appraisal of what is perhaps the most difficult treatise in the philosophical canon. Daniel N. Robinson situates Kant's undertaking in the "First Critique" within the context of the history of philosophy and as a response to the challenges of scepticism. Kant's central task in the "First Critique" is to tie his metaphysical analysis to the very possibility of nature itself. Where others assumed the validity or the weakness of perception and reason, Kant presents a critical appraisal of both, thereby establishing the very limits of sense and reason as instruments of discovery. Ideal for students at all levels, this fascinating introduction clarifies the aims and significance of Kant's project, locates its place within the history of philosophy and identifies the strengths and weaknesses reasonably attributed to this most significant contribution to the history of philosophical reflection.

Scientism: The New Orthodoxy is a comprehensive philosophical overview of the question of scientism, discussing the role and place of science in the humanities, religion, and the social sciences. Clarifying and defining the key terms in play in discussions of scientism, this collection identifies the dimensions that differentiate science from scientism. Leading scholars appraise the means available to science, covering the impact of the neurosciences and the new challenges it presents for the law and the self. Illustrating the effect of scientism on the social sciences, and the humanities, Scientism: the New Orthodoxy addresses what science is and what it is not. This provocative collection is an important contribution to the social sciences and the humanities in the 21st century. Contributors include: Peter Hacker, Bastiaan van Fraassen, Daniel N. Robinson, Kenneth Schaffner, Roger Scruton, James K.A. Smith, Richard Swinburne, Lawrence Principe and Richard N. Williams.

During the 1990s, Russia has been building a new political order. This collection of essays offers a progress report on this effort, recording the projects for institutional reform, their successes and their many failures. Institutions covered include the presidency, the State Duma, regional government, the judiciary, the power ministries, the foreign policy and economic policy making establishments. Other chapters examine popular attitudes towards institutions and the crises of state society relations in Russia.

Historical Introduction The Marfan Syndrome: From Clinical Delineation to Mutational Characterization, a Semiautobiographic Account VictorA. McKusick l n 1876, E. Williams, an ophthalmologistin Cincinnati, Ohio, described ectopia lentis in a brother and sister who were exceptionally tall and had been loosejointed from birth. I Although there is a Williams syndrome that has aortic manifestations (supravalvar aortic stenosis), the name Williams was never associated with the disorder we now call Marfan syndrome. The reason is clear: Williamswas geographically removed from the leading medical centers and published in the Transactions of the American Ophthalmological Society; surely his report attracted little attention and the non-ocular features were not emphasized. 2 The case report that brought the disorder to attention was provided by a prominent Pari- sian professor of pediatrics, Antoine Bernard-Jean Marfan (1858-1942), who did much to establish pediatrics as a specialty in France and elsewhere. He was the author of widely read textbooks and monographson pediatrictopics and waseditor of Le Nourrisson for a great many years. In addition to the syndromeunder discussion here, his name is often attached to "Marfan's law" (that immunity to pulmonary phthisis is conferred by the healing of a local tuberculous 3 lesion) and Marfan's subxiphoid approach for aspiratingfluid from the pericardial sac. (Please pardon my use of the possessive form of the eponym in these two instances!) Pictures of Marfan (Fig.

Multiple pregnancies are associated with higher risks for both mother and babies. Women with multiple pregnancies have an increased risk of miscarriage, anemia, hypertensive disorders, haemorrhage, and postnatal illness. These pregnancies are more likely to need an operative delivery, and maternal mortality is generally 2.5 times that of singleton births. Fetuses are at increased risk for anatomic and genetic anomalies, growth abnormalities, prematurity, and several physiological problems related to monochorionicity. This book provides a much needed, up-to-date guide to the management of multiple pregnancies. Presented with a uniform approach to all chapters, information is easily navigable, evidence-based, and highly practical. Heavily illustrated, particularly with ultrasound images - the cornerstone of management of multiple pregnancies - this book will appeal to obstetricians and specialists in maternal-fetal medicine, midwives and ultrasonographers and will improve outcomes for mothers and babies.

Exome and genome sequencing are revolutionizing medical research and diagnostics, but the computational analysis of the data has become an extremely heterogeneous and often challenging area of bioinformatics. Computational Exome and Genome Analysis provides a practical introduction to all of the major areas in the field, enabling readers to develop a comprehensive understanding of the sequencing process and the entire computational analysis pipeline.

Introduction to Bio-Ontologies explores the computational background of ontologies. Emphasizing computational and algorithmic issues surrounding bio-ontologies, this self-contained text helps readers understand ontological algorithms and their applications. The first part of the book defines ontology and bio-ontologies. It also explains the importance of mathematical logic for understanding concepts of inference in bio-ontologies, discusses the probability and statistics topics necessary for understanding ontology algorithms, and describes ontology languages, including OBO (the preeminent language for bio-ontologies), RDF, RDFS, and OWL. The second part covers significant bio-ontologies and their applications. The book presents the Gene Ontology; upper-level ontologies, such as the Basic Formal Ontology and the Relation Ontology; and current bio-ontologies, including several anatomy ontologies, Chemical Entities of Biological Interest, Sequence Ontology, Mammalian Phenotype Ontology, and Human Phenotype Ontology. The third part of the text introduces the major graph-based algorithms for bio-ontologies. The authors discuss how these algorithms are used in overrepresentation analysis, model-based procedures, semantic similarity analysis, and Bayesian networks for molecular biology and biomedical applications. With a focus on computational reasoning topics, the final part describes the ontology languages of the Semantic Web and their applications for inference. It covers the formal semantics of RDF and RDFS, OWL inference rules, a key inference algorithm, the SPARQL query language, and the state of the art for querying OWL ontologies. Web ResourceSoftware and data designed to complement material in the text are available on the book's website: http://bio-ontologies-book.org The site provides the R Robo package developed for the book, along with a compressed archive of data and ontology files used in some of the exercises. It also offers teaching/presentation slides and links to other relevant websites. This book provides readers with the foundation to use ontologies as a starting point for new bioinformatics research projects or to support current molecular genetics research projects. By supplying a self-contained introduction to OBO ontologies and the Semantic Web, it bridges the gap between both fields and helps readers see what each can contribute to the analysis and understanding of biomedical data.

This book links research in wine marketing/management and wine tourism, offering international and multidisciplinary perspectives. Addressing the evolving nature of the wine tourism industry and market, the book brings in new research streams and technology advances such as; social media, customer empowerment and engagement, co-creation, social / responsible marketing and wine consumption. Each section includes an introductory chapter written by the editors discussing the aims and the chapters of the section. Section chapters provide theoretical and research based insights with practical implications, while every section is also complemented with case studies that further enrich the practice and industry implications of theory. Researchers will find in this book a holistic analysis of research and cases relating to the management and marketing of wine tourism businesses and visitors.

Introduction to Bio-Ontologies explores the computational background of ontologies. Emphasizing computational and algorithmic issues surrounding bio-ontologies, this self-contained text helps readers understand ontological algorithms and their applications.

The first part of the book defines ontology and bio-ontologies. It also explains the importance of mathematical logic for understanding concepts of inference in bio-ontologies, discusses the probability and statistics topics necessary for understanding ontology algorithms, and describes ontology languages, including OBO (the preeminent language for bio-ontologies), RDF, RDFS, and OWL.

The second part covers significant bio-ontologies and their applications. The book presents the Gene Ontology; upper-level ontologies, such as the Basic Formal Ontology and the Relation Ontology; and current bio-ontologies, including several anatomy ontologies, Chemical Entities of Biological Interest, Sequence Ontology, Mammalian Phenotype Ontology, and Human Phenotype Ontology.

The third part of the text introduces the major graph-based algorithms for bio-ontologies. The authors discuss how these algorithms are used in overrepresentation analysis, model-based procedures, semantic similarity analysis, and Bayesian networks for molecular biology and biomedical applications.

With a focus on computational reasoning topics, the final part describes the ontology languages of the Semantic Web and their applications for inference. It covers the formal semantics of RDF and RDFS, OWL inference rules, a key inference algorithm, the SPARQL query language, and the state of the art for querying OWL ontologies.

Web Resource
Software and data designed to complement material in the text are available on the book s website: http: //bio-ontologies-book.org The site provides the R Robo package developed for the book, along with a compressed archive of data and ontology files used in some of the exercises. It also offers teaching/presentation slides and links to other relevant websites.

This book provides readers with the foundation to use ontologies as a starting point for new bioinformatics research projects or to support current molecular genetics research projects. By supplying a self-contained introduction to OBO ontologies and the Semantic Web, it bridges the gap between both fields and helps readers see what each can contribute to the analysis and understanding of biomedical data.

Following the 1948 war and the creation of the state of Israel, Palestinian Arabs comprised just fifteen percent of the population but held a much larger portion of its territory. Offered immediate suffrage rights and, in time, citizenship status, they nonetheless found their movement, employment, and civil rights restricted by a draconian military government put in place to facilitate the colonization of their lands. "Citizen Strangers" traces how Jewish leaders struggled to advance their historic settler project while forced by new international human rights norms to share political power with the very people they sought to uproot.
For the next two decades Palestinians held a paradoxical status in Israel, as citizens of a formally liberal state and subjects of a colonial regime. Neither the state campaign to reduce the size of the Palestinian population nor the formulation of citizenship as a tool of collective exclusion could resolve the government's fundamental dilemma: how to bind indigenous Arab voters to the state while denying them access to its resources. More confounding was the tension between the opposing aspirations of Palestinian political activists. Was it the end of Jewish privilege they were after, or national independence along with the rest of their compatriots in exile? As Shira Robinson shows, these tensions in the state's foundation--between privilege and equality, separatism and inclusion--continue to haunt Israeli society today.

Following the 1948 war and the creation of the state of Israel, Palestinian Arabs comprised just fifteen percent of the population but held a much larger portion of its territory. Offered immediate suffrage rights and, in time, citizenship status, they nonetheless found their movement, employment, and civil rights restricted by a draconian military government put in place to facilitate the colonization of their lands. "Citizen Strangers" traces how Jewish leaders struggled to advance their historic settler project while forced by new international human rights norms to share political power with the very people they sought to uproot.
For the next two decades Palestinians held a paradoxical status in Israel, as citizens of a formally liberal state and subjects of a colonial regime. Neither the state campaign to reduce the size of the Palestinian population nor the formulation of citizenship as a tool of collective exclusion could resolve the government's fundamental dilemma: how to bind indigenous Arab voters to the state while denying them access to its resources. More confounding was the tension between the opposing aspirations of Palestinian political activists. Was it the end of Jewish privilege they were after, or national independence along with the rest of their compatriots in exile? As Shira Robinson shows, these tensions in the state's foundation--between privilege and equality, separatism and inclusion--continue to haunt Israeli society today.

The principal aim of the establishment and free exercise clauses of the First Amendment was to preclude congressional imposition of a national church. A balance was sought between states' rights and the rights of individuals to exercise their religious conscience. While the founding fathers were debating such issues, the potential for serious conflict was confined chiefly to variations among the dominant Christian sects. Today, issues of marriage, child bearing, cultural diversity, and corporate personhood, among others, suffuse constitutional jurisprudence, raising difficult questions regarding the nature of beliefs that qualify as 'religious', and the reach of law into the realm in which those beliefs are held. The essays collected in this volume explore in a selective and instructive way the intellectual and philosophical roots of religious liberty and contemporary confrontations between this liberty and the authority of secular law.

The principal aim of the establishment and free exercise clauses of the First Amendment was to preclude congressional imposition of a national church. A balance was sought between states' rights and the rights of individuals to exercise their religious conscience. While the founding fathers were debating such issues, the potential for serious conflict was confined chiefly to variations among the dominant Christian sects. Today, issues of marriage, child bearing, cultural diversity, and corporate personhood, among others, suffuse constitutional jurisprudence, raising difficult questions regarding the nature of beliefs that qualify as 'religious', and the reach of law into the realm in which those beliefs are held. The essays collected in this volume explore in a selective and instructive way the intellectual and philosophical roots of religious liberty and contemporary confrontations between this liberty and the authority of secular law.

Historical Introduction The Marfan Syndrome: From Clinical Delineation to Mutational Characterization, a Semiautobiographic Account VictorA. McKusick l n 1876, E. Williams, an ophthalmologistin Cincinnati, Ohio, described ectopia lentis in a brother and sister who were exceptionally tall and had been loosejointed from birth. I Although there is a Williams syndrome that has aortic manifestations (supravalvar aortic stenosis), the name Williams was never associated with the disorder we now call Marfan syndrome. The reason is clear: Williamswas geographically removed from the leading medical centers and published in the Transactions of the American Ophthalmological Society; surely his report attracted little attention and the non-ocular features were not emphasized. 2 The case report that brought the disorder to attention was provided by a prominent Pari- sian professor of pediatrics, Antoine Bernard-Jean Marfan (1858-1942), who did much to establish pediatrics as a specialty in France and elsewhere. He was the author of widely read textbooks and monographson pediatrictopics and waseditor of Le Nourrisson for a great many years. In addition to the syndromeunder discussion here, his name is often attached to "Marfan's law" (that immunity to pulmonary phthisis is conferred by the healing of a local tuberculous 3 lesion) and Marfan's subxiphoid approach for aspiratingfluid from the pericardial sac. (Please pardon my use of the possessive form of the eponym in these two instances!) Pictures of Marfan (Fig.

Early in 1986 I invited Professor Robinson to collaborate on a volume of the Annals devoted to the theme of the 'person' in psychology. He accepted my invitation later that year suggesting, instead, that the volume be devoted to the theme of explanation in psychology. I gladly compromised for, as I knew from his exterisive writings on the history and philosophy of psychology, the concept of explanation is firmly rooted in philosophical anthropology. The contributions by Rom Harre, James Lamiell, Joseph Margolis, and George Miller were available in June, 1988, and the commentaries and replies to commentaries early in 1989. Fortunately, foundational papers wear well, as the content of the present volume so aptly testifies. Beginning with Volume 6, the Annals will be entirely edited and prepared using the computer facilities at our Center. Thanks to the dedicated effort of my colleague, Professor William Baker, this is the first volume produced from camera-ready copy. His personal support and technical expertise made the transition to desk-top publishing somewhat less than formidable. Mrs. Valerie Welch, our Center secretary, entered the text and managed my personal correspondence; Casey Boodt proofread the entire manuscript; and the University of Alberta continues to support my involvement with this series. Dan Robinson's commitment to scholarship also extends to the more mundane task of editing. Every volume with a co-editor is a challenge; he made this one a delight.

Since its inception in 1968, software engineering has undergone numerous changes. In the early years, software development was organized using the waterfall model, where the focus of requirements engineering was on a frozen requirements document, which formed the basis of the subsequent design and implementation process. Since then, a lot has changed: software has to be developed faster, in larger and distributed teams, for pervasive as well as large-scale applications, with more flexibility, and with ongoing maintenance and quick release cycles.

What do these ongoing developments and changes imply for the future of requirements engineering and software design? Now is the time to rethink the role of requirements and design for software intensive systems in transportation, life sciences, banking, e-government and other areas. Past assumptions need to be questioned, research and education need to be rethought.

This book is based on the Design Requirements Workshop, held June 3-6, 2007, in Cleveland, OH, USA, where leading researchers met to assess the current state of affairs and define new directions. The papers included were carefully reviewed and selected to give an overview of the current state of the art as well as an outlook on probable future challenges and priorities. After a general introduction to the workshop and the related NSF-funded project, the contributions are organized in topical sections on fundamental concepts of design; evolution and the fluidity of design; quality and value-based requirements; requirements intertwining; and adapting requirements practices in different domains.

Vladimir Putin's return to the Kremlin for a fourth presidential term in 2018 has seen Russian democracy weaken further and Russia's relations with the West deteriorate seriously. Yet, within Russia, Putin's position remains unchallenged and his foreign policy battles have received widespread public support. But is Putin as safe as his approval ratings lead us to believe? And how secure is the regime that he heads? In this new book, Neil Robinson places contemporary Russian politics in historical perspective to argue that Putin's regime has not overcome the problems that underpinned the momentous changes in twentieth-century Russian history when the country veered from tsarism to Soviet rule to post-communist chaos. The first part of the book, outlining why crises have been perennial problems for Russia, is followed by an exploration of contemporary Russian political institutions and policy to show how Putin has stabilised Russian politics. But, while Putin's achievements as a politician have been considerable in strengthening his personal position, they have not dealt successfully with the enduring problem of the Russian state's functionality. Like other Russian rulers, Putin has been much better at establishing a political system that supports his rule than he has at building up a state that can deliver material wealth and protection to the Russian people. As a result, Robinson argues, Russia has been and remains vulnerable to political crisis and regime change.

Vladimir Putin's return to the Kremlin for a fourth presidential term in 2018 has seen Russian democracy weaken further and Russia's relations with the West deteriorate seriously. Yet, within Russia, Putin's position remains unchallenged and his foreign policy battles have received widespread public support. But is Putin as safe as his approval ratings lead us to believe? And how secure is the regime that he heads? In this new book, Neil Robinson places contemporary Russian politics in historical perspective to argue that Putin's regime has not overcome the problems that underpinned the momentous changes in twentieth-century Russian history when the country veered from tsarism to Soviet rule to post-communist chaos. The first part of the book, outlining why crises have been perennial problems for Russia, is followed by an exploration of contemporary Russian political institutions and policy to show how Putin has stabilised Russian politics. But, while Putin's achievements as a politician have been considerable in strengthening his personal position, they have not dealt successfully with the enduring problem of the Russian state's functionality. Like other Russian rulers, Putin has been much better at establishing a political system that supports his rule than he has at building up a state that can deliver material wealth and protection to the Russian people. As a result, Robinson argues, Russia has been and remains vulnerable to political crisis and regime change.