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Personalized nutrition involves the formulation of individualized
nutritional recommendations to promote and maintain health based on
an individual's genetic makeup and other unique intrinsic and
extrinsic factors. Implementing personalized nutrition plans for
individuals with certain diseases or who are in danger of
developing health conditions could help control the onset and
severity of symptoms. Personalized Nutrition as Medical Therapy for
High-Risk Diseases offers a practical guide for physicians seeking
to provide tailored dietary recommendations to their patients with
disease treatment, modulation and prevention in mind. The book
focuses on the biological mechanisms of specific diseases and
provides evidence for how personalized nutrition positively impacts
them. It explores conditions including cardiovascular diseases,
hypertension, hypercholesteromia, diabetes, obesity, Crohn's
disease, as well as multiple pediatric, renal and psychological
disorders. Features: * Includes case studies that document how
people respond differently towards food depending on their genetic
structure and other factors. * Discusses genome wide association
studies (GWIMS) to understand the interplay between genetic
susceptibility and dietary interactions. * Provides users
information to effectively implement personalized nutrition into
practice. * Identifies possible challenges to the implementation of
personalized nutritional interventions in a clinical setting. This
book is for medical practitioners and will also appeal to
researchers and students.
As nutrition research is shifting its focus from epidemiology and
physiology to effects of nutrients at the molecular level, a
uniquely tailored diet that corresponds to the demands of our
genetic signature is emerging as an indispensable need. Using
high-throughput genomic tools, nutrigenomics unravels the influence
of micro- and macronutrients as potent dietary signals regulating
metabolic pathways and unmasks how susceptible genotypes are
predisposed to diet-related diseases. Selected topics from this
field have been covered in some books, but no other comprehensive
text on epigenetics, nutrition, and human health and disease is
available, until now. This book illustrates nutrition's influence
on epigenetic inheritance and the mechanisms underlying the
modification of the metabolic imprint of an individual. This
enriched understanding of nutrigenomics can be applied to master a
tailored diet that can alleviate imprinted metabolic syndromes.
Specifically, the book focuses on: * Maternal, perinatal, and
neonatal nutrition * Epigenetic mechanisms and cancer * Impacts of
dietary factors, folate deficiency and DNA methylation *
Nutrition's influence on genetic imprinting * The basics of
nutrigenomics and epigenetic regulation
Personalized nutrition involves the formulation of individualized
nutritional recommendations to promote and maintain health based on
an individual's genetic makeup and other unique intrinsic and
extrinsic factors. Implementing personalized nutrition plans for
individuals with certain diseases or who are in danger of
developing health conditions could help control the onset and
severity of symptoms. Personalized Nutrition as Medical Therapy for
High-Risk Diseases offers a practical guide for physicians seeking
to provide tailored dietary recommendations to their patients with
disease treatment, modulation and prevention in mind. The book
focuses on the biological mechanisms of specific diseases and
provides evidence for how personalized nutrition positively impacts
them. It explores conditions including cardiovascular diseases,
hypertension, hypercholesteromia, diabetes, obesity, Crohn's
disease, as well as multiple pediatric, renal and psychological
disorders. Features: * Includes case studies that document how
people respond differently towards food depending on their genetic
structure and other factors. * Discusses genome wide association
studies (GWIMS) to understand the interplay between genetic
susceptibility and dietary interactions. * Provides users
information to effectively implement personalized nutrition into
practice. * Identifies possible challenges to the implementation of
personalized nutritional interventions in a clinical setting. This
book is for medical practitioners and will also appeal to
researchers and students.
With cardiovascular disease remaining one of the primary causes of
morbidity and mortality worldwide, there is a great need to further
understand the molecular basis of this disease class and develop
new therapeutic or preventative measures. Cardiovascular Diseases:
Nutritional and Therapeutic Interventions presents up-to-date
information on the pathobiology of cardiovascular diseases,
emphasizing emerging therapeutics and nutritional interventions.
The book is divided into four parts: epidemiology, epigenetics,
pathobiology, and therapies for cardiovascular diseases. Part I
details epidemiological studies, highlighting the extent of the
clinical problem. Part II describes the genetic and, primarily,
epigenetic modifications associated with cardiovascular disease,
including the importance of DNA methylation status and the
possibility of early intervention using simple dietary
modifications. The text also discusses histone modifications
associated with disease and potential therapeutic synthetic and
dietary compounds such as resveratrol and garlic. Covering the
etiology and pathobiology, part III discusses lipid regulation,
micro-RNAs, emerging cell-based therapies, and new receptor targets
for therapeutics as well as targeted imaging. It also describes the
link between cancer therapies and cardiomyopathy and the potential
of vitamin C to ameliorate this effect. Part IV focuses on
therapeutic and nutritional interventions, namely, stem cell
therapies, emerging nanomedicines, and a wide range of dietary
interventions. These include general healthy diets, fruits and
vegetables, botanicals, effects of specific compounds such as
antioxidants, and discussions on garlic, curcumin, and resveratrol.
The text also covers lifestyle factors, emphasizing the importance
of stress in the occurrence of and meditation and yoga in the
management of cardiovascular disease. This book provides a
comprehensive reference for clinicians and scientists, combining
epidemiology, prevention, and modern treatment strategies.
In a simplified form, epigenetics refers to heritable changes in
phenotype that are not due to changes in the underlying DNA
sequence. In this book, epigenetic mechanisms of regulation and
dysregulation in health and disease are explored in great depth.
Detailed chapters on epigenetic processes including DNA methylation
and chromatin post-translational modifications including potential
interventions with DNA methyltransferase inhibitors and histone
deacetylase inhibitors are explored in initial chapters. These
provide a detailed overview and important background to the entire
field. The book is then focussed on epigenetic mechanisms involved
in various diseases including anti-inflammatory and autoimmune
conditions. Important accounts relating to the effects of
epigenetics in metabolic syndrome, cardiovascular disease and
asthma are the focus of subsequent chapters. The role of epigenetic
dysregulation in malignancy is a current topic of interest and
represents an intense field of research. A large component of this
book is dedicated to the analysis of aberrant epigenetic processes
in carcinogenesis and cancer progression. Further, chapters are
focused on emerging cancer prevention using nutritional components
and anti-cancer therapies particularly with histone deacetylase
inhibitors, which have already been approved for the treatment of
cutaneous T-cell lymphoma. The emerging role of nanoparticle
preparations, especially in the context of delivering potential
epigenetic therapies to target cells in various diseases, is also
explored in this book. Overall, this book encompasses a wide range
of topics related to epigenetic mechanisms in health and disease
and would appeal to anyone with an interest in epigenetics,
chromatin biology and emerging epigenetic interventions and
therapies.
In a simplified form, epigenetics refers to heritable changes in
phenotype that are not due to changes in the underlying DNA
sequence. In this book, epigenetic mechanisms of regulation and
dysregulation in health and disease are explored in great depth.
Detailed chapters on epigenetic processes including DNA methylation
and chromatin post-translational modifications including potential
interventions with DNA methyltransferase inhibitors and histone
deacetylase inhibitors are explored in initial chapters. These
provide a detailed overview and important background to the entire
field. The book is then focussed on epigenetic mechanisms involved
in various diseases including anti-inflammatory and autoimmune
conditions. Important accounts relating to the effects of
epigenetics in metabolic syndrome, cardiovascular disease and
asthma are the focus of subsequent chapters. The role of epigenetic
dysregulation in malignancy is a current topic of interest and
represents an intense field of research. A large component of this
book is dedicated to the analysis of aberrant epigenetic processes
in carcinogenesis and cancer progression. Further, chapters are
focused on emerging cancer prevention using nutritional components
and anti-cancer therapies particularly with histone deacetylase
inhibitors, which have already been approved for the treatment of
cutaneous T-cell lymphoma. The emerging role of nanoparticle
preparations, especially in the context of delivering potential
epigenetic therapies to target cells in various diseases, is also
explored in this book. Overall, this book encompasses a wide range
of topics related to epigenetic mechanisms in health and disease
and would appeal to anyone with an interest in epigenetics,
chromatin biology and emerging epigenetic interventions and
therapies.
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