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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
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Molecular mechanisms and physiology of disease - Implications for Epigenetics and Health (Paperback, Softcover reprint of the original 1st ed. 2014)
Loot Price: R7,018
Discovery Miles 70 180
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Molecular mechanisms and physiology of disease - Implications for Epigenetics and Health (Paperback, Softcover reprint of the original 1st ed. 2014)
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In a simplified form, epigenetics refers to heritable changes in
phenotype that are not due to changes in the underlying DNA
sequence. In this book, epigenetic mechanisms of regulation and
dysregulation in health and disease are explored in great depth.
Detailed chapters on epigenetic processes including DNA methylation
and chromatin post-translational modifications including potential
interventions with DNA methyltransferase inhibitors and histone
deacetylase inhibitors are explored in initial chapters. These
provide a detailed overview and important background to the entire
field. The book is then focussed on epigenetic mechanisms involved
in various diseases including anti-inflammatory and autoimmune
conditions. Important accounts relating to the effects of
epigenetics in metabolic syndrome, cardiovascular disease and
asthma are the focus of subsequent chapters. The role of epigenetic
dysregulation in malignancy is a current topic of interest and
represents an intense field of research. A large component of this
book is dedicated to the analysis of aberrant epigenetic processes
in carcinogenesis and cancer progression. Further, chapters are
focused on emerging cancer prevention using nutritional components
and anti-cancer therapies particularly with histone deacetylase
inhibitors, which have already been approved for the treatment of
cutaneous T-cell lymphoma. The emerging role of nanoparticle
preparations, especially in the context of delivering potential
epigenetic therapies to target cells in various diseases, is also
explored in this book. Overall, this book encompasses a wide range
of topics related to epigenetic mechanisms in health and disease
and would appeal to anyone with an interest in epigenetics,
chromatin biology and emerging epigenetic interventions and
therapies.
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