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This book comprehensively reviews various nanodiagnostic approaches
for the detection of bacterial pathogens. The initial chapter of
the book discusses receptors present on bacterial cell surfaces
that can be targeted for diagnostic applications. The book then
presents different fluorescent nanoparticle systems that are used
for bacterial detection. Further, it covers surface plasmon
resonance (SPR), ELISA, and QCM-based nanosensors to detect
pathogenic bacteria. It examines different nanosensors used for the
microfluidic-based detection of bacterial pathogens, including
microfluidic paper-based analytical devices (μPADs), lateral flow
devices, and miniaturized PCR devices. The book also covers the
current electrochemical, voltammetric, and amperometric
nanosensors-based microorganism recognition approaches. Lastly, the
book summarizes the current challenges and the futuristic
application of nanosensors to detect bacterial pathogens. This book
is an invaluable resource for all medical laboratories and clinical
institutions dealing with infectious diseases.
This book gathers selected high-quality research papers presented
at the International Conference on Paradigms of Communication,
Computing and Data Sciences (PCCDS 2021), held at the National
Institute of Technology, Kurukshetra, India, during May 07-09,
2021. It discusses high-quality and cutting-edge research in the
areas of advanced computing, communications, and data science
techniques. The book is a collection of latest research articles in
computation algorithm, communication, and data sciences,
intertwined with each other for efficiency.
Although green innovation and technology is not new, so far very
limited information is available regarding the diversified
approaches for green technologies and engineering. This book
highlights the challenges and opportunities, offering a roadmap for
using various approaches in the most cost effective way. The book
discusses the interrelationship between a circular economy and
green technologies. It presents the dimensions of green innovations
and illustrates the challenges of industrialization, especially in
terms of material synthesis and utilized processes. It covers the
current environmental and health challenges of societies and
describes the role of stakeholders in developing sustainable
societies and industries. This book provides a line of approach to
core and interdisciplinary students, academicians, research
scientists, and various industry personnel to present their ideas
of green innovations with a common vision of sustainable
development of community and industries in mind. Features Discusses
the interrelationship between a circular economy and green
technologies Presents the dimensions of green innovations
Illustrates the challenges of industrialization, especially in
terms of material synthesis and utilized processes Covers the
current environmental and health challenges of societies Offers the
identification and role of stakeholders in the sustainable
development of societies and industries
This book gathers selected high-quality research papers presented
at the International Conference on Paradigms of Communication,
Computing and Data Sciences (PCCDS 2021), held at the National
Institute of Technology, Kurukshetra, India, during May 07-09,
2021. It discusses high-quality and cutting-edge research in the
areas of advanced computing, communications, and data science
techniques. The book is a collection of latest research articles in
computation algorithm, communication, and data sciences,
intertwined with each other for efficiency.
Bioaerosols Emission from Anthropogenic Sources: Influencing
Factors, Microbial Diversity, Epidemiological Threats, and Control
Approaches covers various sources of biohazards and their
associated risk factors. These air contaminants are developing
concerns to people and the environment and must be addressed to
avert future dangers. As little is known about their precise
sources, controlling variables, microbial diversity, the
involvement of co-pollutants, and dispersion and control methods,
this book will assist stakeholders, including the public,
government officials, and policymakers in developing successful
strategies for ensuring society's safety.
Cancer is a disease characterized by reduction or loss of
effectiveness in normal cellular control mechanism which regulates
multiplication. A normal cell turns into a cancer cell because of
one or more mutations in its DNA, which can be acquired or
inherited. In the body, every cell type has its own unmatched
signature, referred to as biomarkers, they are useful in the
diagnosis, monitoring and in predicting the disease progression. It
is found that the mediators of inflammation are important
constituents of the local environment of tumors. In some types of
cancer, inflammatory conditions are present before a malignant
change develops. Conversely, in other types of cancer, an oncogenic
change induces an inflammatory microenvironment which promotes the
tumor development. In some cases, use of NSAIDs is associated with
lower risks for esophageal, gastric and colon cancers as well as
other solid tumors. Chronic intake of NSAIDs may reduce
carcinogenesis by inhibiting production of PGs, cytokines and
angiogenic factors. Moreover, the ability of these NSAIDs drugs to
prevent cancer is thought to be due, in part, to COX inhibition.
This book deals with the concept of isosterism, bioisosterism and
retroisosterism. Specifically it gives the bioisosteric correlation
of tetrazole moiety with carboxylic group with the help of
different parameters and theories. Carboxylic group is chiefly
presents in proteins and peptides, thus emphasis is laid on the
fact that how this carboxylic acid has been replaced by the
tetrazoles in development of new chemical entities which are under
clinical trials and others which are prevailing as drugs in market.
Effective results in pharmacokinetic and pharmacodynamic properties
of compounds have been observed. This book also highlights the
effect of tetrazoles in place of carboxylic groups, studied
specifically as templates in growth hormone, as in anti-HIV agents
and as modifier of enzyme activity. Lastly it gives the idea of
retroisosterism which is based on the inversion of a determined
functional group present in the lead compound structure.
Furthermore, the role of bioisosters in drug development and drug
discovery is briefly discussed along with the future prospects.
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