This volume educates physicians on the basic knowledge of ESD, from indication of this technique to assessing suitability and technical aspects of each important step. The text is structured to guide readers to understand the principles, including history, why ESD was designed and developed, indications, as well as how to evaluate lesions and perform actual procedures. Abundant photographs and diagrams illustrate the key points and promote "pattern recognition". The text also introduces gastroenterologists to early gastrointestinal lesions, which have not been recognized in clinical practice for many years. To assist in the treatment process of ESD, highly practical information is provided, separated by different anatomical locations, as well as management of complications. The volume is also accompanied by an online video library. Written by experts in Asian countries with vast experience with this technique, as well as experts from the U.S., South America, and Europe, Endoscopic Submucosal Dissection: Principles and Practice provides a major reference for gastroenterologists and surgeons on ESD.

In this issue of Gastrointestinal Endoscopy Clinics of North America, we invited pioneers and experts in this field to share recent advancements and expansions of ESD and its technical aspects in different organ systems. In addition, this issue covers the associated techniques of per oral endoscopic myotomy (POEM) and natural orifice transluminal endoscopic surgery (NOTES) to further advance understanding of the latest breakthroughs in endoscopic therapy. Current trends surrounding ESD around the world-in Asia, Europe, and the United States-are addressed as well. Some articles include videos for readers to watch ESD procedures in action, performed by experts, for easier understanding of ESD techniques. The Guest Editors expect that this issue will inspire more physicians to explore the expanding possibilities of endoscopic therapy such as ESD and POEM and to advocate minimally invasive treatment for patients.