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Chromatin Readers in Health and Disease, Volume 35, a new release
in the Translational Epigenetics series, gathers and makes
actionable our current understanding of how chromatin readers
regulate access to genetic information, and how their aberrant
regulation can contribute to human pathologies. Chromatin readers
discussed include 14-3-3 Dinshaw, ADD, Ankyrin, BAH, BET, BIR,
BRCT, bromodomains and Kac readers, chromodomains and chromobarrel
readers, citrullination readers, macrodomains and poly-ADP-ribose
readers, MBT, PHD and double PHD, PWWP, SUMO (H4K12) readers, Tudor
and TTD, UDR and ubiquitin, WD40, YEATS (crotonyl reader), MBD,
SRA, and Methyl-RNA readers. In the book, more than a dozen leaders
in the field examine a range of protein readers, their relationship
to human disease, and the early therapeutics that act as chromatin
signaling factors to treat cancers and Huntington's disease, among
other disorders.
Chromatin Signaling and Diseases covers the molecular mechanisms
that regulate gene expression, which govern everything from
embryonic development, growth, and human pathologies associated
with aging, such as cancer. This book helps researchers learn about
or keep up with the quickly expanding field of chromatin signaling.
After reading this book, clinicians will be more capable of
explaining the mechanisms of gene expression regulation to their
patients to reassure them about new drug developments that target
chromatin signaling mechanisms. For example, several epigenetic
drugs that act on chromatin signaling factors are in clinical
trials or even approved for usage in cancer treatments,
Alzheimer's, and Huntington's diseases. Other epigenetic drugs are
in development to regulate various class of chromatin signaling
factors. To keep up with this changing landscape, clinicians and
doctors will need to stay familiar with genetic advances that
translate to clinical practice, such as chromatin signaling.
Although sequencing of the human genome was completed over a decade
ago and its structure investigated for nearly half a century,
molecular mechanisms that regulate gene expression remain largely
misunderstood. An emerging concept called chromatin signaling
proposes that small protein domains recognize chemical
modifications on the genome scaffolding histone proteins,
facilitating the nucleation of enzymatic complexes at specific loci
that then open up or shut down the access to genetic information,
thereby regulating gene expression. The addition and removal of
chemical modifications on histones, as well as the proteins that
specifically recognize these, is reviewed in Chromatin Signaling
and Diseases. Finally, the impact of gene expression defects
associated with malfunctioning chromatin signaling is also
explored.
Chromatin Signaling and Neurological Disorders, Volume Seven,
explores our current understanding of how chromatin signaling
regulates access to genetic information, and how their aberrant
regulation can contribute to neurological disorders. Researchers,
students and clinicians will not only gain a strong grounding on
the relationship between chromatin signaling and neurological
disorders, but they'll also discover approaches to better interpret
and employ new diagnostic studies and epigenetic-based therapies. A
diverse range of chapters from international experts speaks to the
basis of chromatin and epigenetic signaling pathways and specific
chromatin signaling factors that regulate a range of diseases. In
addition to the basic science of chromatin signaling factors, each
disease-specific chapter speaks to the translational or clinical
significance of recent findings, along with important implications
for the development of epigenetics-based therapeutics. Common
themes of translational significance are also identified across
disease types, as well as the future potential of chromatin
signaling research.
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