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Showing 1 - 25 of 44 matches in All Departments
We are now on the verge of viewing effector molecules and other regulatory sites as therapeutic targets for the amelioration of human and animal disease. The recognition, for example, that mutant proteins are frequently misrouted molecules, rather than functionally defective ones, changes our approach to "inborn errors of metabolism" and offers new approaches for pharmacological discovery, based on rescue of receptors, ion channels and enzymes with pharmacoperones. Ion channels, regulators of G-protein signaling and enzymes engaged in regulation, now present opportunities for drug development. The state of our art also benefits by the availability of superior tools that allow measurement of interactions and afford unprecedented insight into the biomolecular interactions that present novel approaches to drug design.
A compendium of thirty-four powerful techniques for identifying and analyzing the diversity of proteins expressed in cells. Thee readily reproducible proteomic methods range from general to specific techniques, and include methods for data analysis, posttranslational modification, and its variants and isoforms. Additional methods demonstrate the application of proteomics to the discovery of serological tumor markers, to identifying the determinants of sensitivity to antitumor drugs, and to specialized fields, such as endocrinology, plant biology, nephrology, and urology.
A panel of leading experts integrate the latest findings from basic and clinical science to create a comprehensive treatment of the processes by which the brain acts as an endocrine organ, not only to control hormonal functions, but also to maintain homeostasis and regulate behavior. The authors-recognized both as leaders in their fields and as skilled teachers-provide systematic coverage of the analytical, anatomical, functional, clinical, and pathological aspects of neuroendocrinology. Topics range from the interactions between the nervous and endocrine systems to the regulation of reproduction, development, metabolism, fluid balance, and biological rhythms. Neuroendocrinology in Physiology and Medicine offers an unprecedented marriage of clinical and basic knowledge that has been missing from classical neuroscience, endocrinology, and physiology texts. It will teach today's medical students and serve researchers as a valuable reference to this rapidly growing field.
This practical book provides the detailed methodology and expert
guidance required for measuring and manipulating cytosolic ion
concentrations. In addition, the strengths, weaknesses, and
pitfalls of various techniques are presented. It is an invaluable
source for those needing an objective evaluation of current
methodologies and for those contemplating setting up such
procedures.
The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.
This volume covers the most significant advances of the last ten years in understanding intermediary nitrogen metabolism in plants. The eight chapters comprise aspects of nitrate and nitrogen assimilation, symbiotic nitrogen fixation, glutamine and glutamate enzymology, amino acid biosynthesis, ureides, and polyamine and sulfur metabolism. The volume emphasizes molecular and genetic advances as well as biochemistry and physiology. Intermediary Nitrogen Metabolism will be of interest to all plant biochemists and molecular geneticists who study nitrogen metabolism, enzymology, and amino acids.
The Biochemistry of Plants, Volume 14: Carbohydrates provides information pertinent to the fundamental aspects of plant biochemistry. This book deals with the function and structure of the plant cell wall by describing the physical and chemical properties of cell wall components. Organized into 11 chapters, this volume begins with an overview of hexose phosphate metabolism in nonphotosynthetic tissues. This text then examines the findings in fructan structures, conformations, and linkages, the enzymes involved in fructan synthesis and degradation, and their cellular regulation, location, and metabolic role in plants. Other chapters consider the methods employing enzymes to determine starch structure. This book discusses as well the different biosynthetic modes of plant cell walls. The final chapter deals with the various environmental factors that influence expression of the ?-amylase gene, suggesting how molecular biology may help in understanding carbohydrate biochemistry and the enzymes involved in carbohydrate synthesis and metabolism. This book is a valuable resource for plant biochemists.
Since the awarding of the Nobel Prize to Drs. Guillemin and Schally iJ) 1971 for isolation and chemical characterization of gonadotropin releasing hormone, we have experienced a remarkable period of growth of interest in this hormone. The last 20 years have been characterized by a swift translation of basic science discovery into clinical utility. Approval of GnRH and its analogs for treatment of prostate cancer, endometriosis, of ovulation indicate the range and precocious puberty and for induction of these agents. of usefulness In order to bring together the leaders in the basic and clinical science of GnRH, a conference was organized on "Modes of Action of GnRH and GnRH Analogs" and held in Scottsdale, Arizona, February 26 to March 2, 1991. The presentations, given as chapters in this volume, show both the advances in the body of information in this discipline and the efforts underway to reduce basic science to clinical practice. The audience was a combination of representatives from universities, government, industry, and physicians in practice. The lively discussions and insightful questions indicated the interest in the topics discussed and frequently served to catalyze planned interactions of the meeting participants. The organizers are grateful to the speakers and poster presenters for their contributions and for the timely preparations of the manuscripts included in the present volume. We are also thankful to the staff of Serono Symposia, USA, for the organizational skills and support that allowed the meeting organizers to focus on the science and medicine presented.
THE STATE oF HoRMONE AcTioN levels were induced in concert with ligand occupa tion of certain membrane receptors and this second AND MoLECULAR REGULATION messenger (cAMP) was postulated to initiate intra cellular phosphorylation of unknown targets. At Molecular Endocrinology and Regulation is a this point, the field ofPeptide Hormone Action also burgeoning field, having experienced a remarkable came into being. period of growth since the late 1960s. At that time, These fields developed together for much ofthe there was no field of Hormone Action. The prevail next decade. Hormone Action Conferences invari ing view of how hormones worked ranged from ably contained talks on both types of receptors and effects on membrane transport of nutrients and progress was rapid and in concert with the explo precursors for RNA and protein synthesis, to effects sion molecular biology. In the steroid field, on the translation of mRN A at the level of ribo progress was more rapid initially, but by the mid somes. Therewas, however, asmallcadreofvoices 1980s, the peptide field attained equal mechanistic that predicted a possible nuclear action on mRN A status and the source of specialized conferences of synthesis. The first such paper was presented at the national endocrine meetings in 1967 and dealt with its own. Steroid hormone action investigators concen hormonal stimulation of oviductal protein synthe tratedonfirst understanding the "pathway" of action sis. It was about this time that a small group of for their hormones."
A panel of leading experts integrate the latest findings from basic and clinical science to create a comprehensive treatment of the processes by which the brain acts as an endocrine organ, not only to control hormonal functions, but also to maintain homeostasis and regulate behavior. The authors-recognized both as leaders in their fields and as skilled teachers-provide systematic coverage of the analytical, anatomical, functional, clinical, and pathological aspects of neuroendocrinology. Topics range from the interactions between the nervous and endocrine systems to the regulation of reproduction, development, metabolism, fluid balance, and biological rhythms. Neuroendocrinology in Physiology and Medicine offers an unprecedented marriage of clinical and basic knowledge that has been missing from classical neuroscience, endocrinology, and physiology texts. It will teach today's medical students and serve researchers as a valuable reference to this rapidly growing field.
A compendium of thirty-four powerful techniques for identifying and analyzing the diversity of proteins expressed in cells. Thee readily reproducible proteomic methods range from general to specific techniques, and include methods for data analysis, posttranslational modification, and its variants and isoforms. Additional methods demonstrate the application of proteomics to the discovery of serological tumor markers, to identifying the determinants of sensitivity to antitumor drugs, and to specialized fields, such as endocrinology, plant biology, nephrology, and urology.
"Cellular Endocrinology in Health and Disease" describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. Among these are those whose function was not obvious until recently, including the endocrine functions of bone and the adipose tissue. Providing content that crosses disciplines, "Cellular
Endocrinology in Health and Disease" details how cellular endocrine
function contributes to system physiology and mediates endocrine
disorders. A methods section proves novel and useful approaches
across research focus that will be attractive to medical students,
residents, and specialists in the field of endocrinology, as well
as to those interested in cellular regulation. Editors Alfredo
Ulloa-Aguirre and P. Michael Conn, experts in molecular and
cellular aspects of endocrinology, deliver contributions carefully
selected for relevance, impact, and clarity of expression from
leading field experts.
"Fluorescence Microscopy: Super-Resolution and other Novel Techniques" delivers a comprehensive review of current advances in fluorescence microscopy methods as applied to biological and biomedical science. With contributions selected for clarity, utility, and reproducibility, the work provides practical tools for investigating these ground-breaking developments. Emphasizing super-resolution techniques, light sheet microscopy, sample preparation, new labels, and analysis techniques, this work keeps pace with the innovative technical advances that are increasingly vital to biological and biomedical researchers. With its extensive graphics, inter-method comparisons, and
tricks and approaches not revealed in primary publications,
"Fluorescence Microscopy" encourages readers to both understand
these methods, and to adapt them to other systems. It also offers
instruction on the best visualization to derive quantitative
information about cell biological structure and function,
delivering crucial guidance on best practices in related laboratory
research.
This new volume of "Methods in Enzymology" continues the legacy
of this premier serial with quality chapters authored by leaders in
the field. This is thesecond of two volumes on endosome signaling
and includes chapters on such topics as measurement of entry into
the endosomal compartment by multi-parametric image analysis,
assessment of peptide internalization and endosomal signaling, and
VEGF-A in endosomal signaling.
This new volume of "Methods in Enzymology" continues the legacy
of this premier serial with quality chapters authored by leaders in
the field. This is the first of two volumes on endosome signaling
and includes chapters on such topics as measurement of entry into
the endosomal compartment by multi-parametric image analysis,
assessment of peptide internalization and endosomal signaling, and
VEGF-A in endosomal signaling.
This new volume of "Methods in Cell Biology" looks at receptor-receptor interactions, with sections on allosteric and effector interactions, crystallization and modeling, measuring receptor-receptor interactions and oligomerization in individual classes. With cutting-edge material, this comprehensive collection is
intended to guide researchers of receptor-receptor interactions for
years to come.
"Animal Models for the Study of Human Disease" identifies
important animal models and assesses the advantages and
disadvantages of each model for the study of human disease.
Thefirst section addresses how to locate resources, animal
alternatives, animal ethics and related issues, much needed
information for researchers across the biological sciences and
biomedicine.The next sections of the work offers models for
disease-oriented topics, including cardiac and pulmonary diseases,
aging, infectious diseases, obesity, diabetes, neurological
diseases, joint diseases, visual disorders, cancer, hypertension,
genetic diseases, and diseases of abuse.
This new volume of "Methods in Enzymology" continues the legacy of
this premier serial by containing quality chapters authored by
leaders in the field. This volume coversG protein
coupledreceptorsandincludes chapterson such topics as G
protein-coupled receptor trafficking motifs, structure-based
virtual screening, and automation-friendly high throughput assays
for identification of pharmacoperone drugs.
This new volume of "Methods in Enzymology" continues the legacy
of this premier serial by containing quality chapters authored by
leaders in the field. This volume covers G protein coupled
receptors and includes chapters on such topics as post-translation
modification of GPCR in relationship to biased agonism,
structure-based virtual screening, and GPCR oligomerization in the
brain.
Cell biology spans among the widest diversity of methods in the biological sciences. From physical chemistry to microscopy, cells have given up with secrets only when the questions are asked in the right way This new volume of "Methods in Cell Biology" covers laboratory methods in cell biology, and includes methods that are among the most important and elucidating in the discipline, such as bioluminescent imaging of gene expressions, confocal imaging, and electron microscopy of bone. Covers the most important laboratory methods in cell biologyChapters written by experts in their fields"
Cell biology spans among the widest diversity of methods in the biological sciences. From physical chemistry to microscopy, cells have given up with secrets only when the questions are asked in the right way This new volume of "Methods in Cell Biology" covers laboratory methods in cell biology, and includes methods that are among the most important and elucidating in the discipline, such as transfection, cell enrichment and magnetic batch separation. Covers the most important laboratory methods in cell biology
Chapters written by experts in their fields
This volume of Methods in Enzymology is thethird of 3 parts
looking at current methodology for the imaging and spectroscopic
analysis of live cells. The chapters provide hints and tricks not
available in primary research publications. It is an invaluable
resource for academics, researchers and students alike.
This volume of Methods in Enzymology is thesecond of 3 parts
looking at current methodology for the imaging and spectroscopic
analysis of live cells. The chapters provide hints and tricks not
available in primary research publications. It is an invaluable
resource for academics, researchers and students alike.
This volume of Methods in Enzymology is the first of 3 parts
looking at current methodology for the imaging and spectroscopic
analysis of live cells. The chapters provide hints and tricks not
available in primary research publications. It is an invaluable
resource for academics, researchers and students alike.
This volume explores some of the most exciting recent advances in basic research on animal models of molecular pathology. |
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