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A detailed review on HIV and its drugs was prepared. This broad
spectrum of biochemical targets has been facilitated by the
synthetic versatility of heterocyclic compounds, which has allowed
the generation of a large number of structurally diverse
derivatives. The objective of this review to systematically
evaluate the pharmacological properties of various substituted
heterocyclic compounds and collate these findings to be used as a
guide for future structure-activity relationship and mode of action
studies. This is the first review to comprehensively discuss the
HIV and its drugs.
Nitrogen containing synthetically and biologically important
heterocyclic ring system namely pyrimidine have been reviewed.
Based on review the pyrimidine derivatives will obtained by the
various condensation methods. The structures of these compounds
will evident by elemental analysis such as, IR, 1H NMR and mass
spectral analysis. These biologically important pyrimidine and
fused pyrimidine compounds will investigated for their
antiinflammatory, antibacterial, antifungal and antiTB activities
A variety of imidazole, and fused imidazole derivatives have been
reviewed. Continuous efforts on combination of lead optimization
and molecular modeling studies in synthesis and the structure
activity relationship studies and biological activities of novel
modi ed imidazole, and fused imidazole derivatives, allowed to
identi cation of novel imidazole derivatives as potent anti TB,
antimicrobial and antidepressant agents."
Development in biological evaluation of heterocyclic molecules has
undergone manifold changes and the advancement in molecular biology
has eased the design of new molecules based on their mechanism of
action. Proposed work is based upon the development of newer
analogues of benzothiazoles followed by their biological
evaluation. Benzothiazoles have been reported with good biological
activities ranging from antiparasitic, anti-inflammatory,
antitumour, p56lck inhibition, immunosuppressive antitubercular
activity etc. The derivatives of benzothiazoles have been developed
very recently, targeting antitumour activity by various workers.
The type of molecules are reported to act based upon their
interaction with aryl hydrocarbon receptor as well as their
interaction with p56lck. Reports are available mentioning the
importance of metabolism and the deactivation of the molecules with
respect to their biopotency.This gives an additional avenue for the
researchers to work upon the concept of prodrug and mutual prodrugs
of these bioactive molecules and come up with better activity
profile. With this background, we thought to develop newer
analogues of the nucleus benzothiazole.
These novel ''one'' and ''thione'' derivatives were synthesized by
using established methods and were characterized by IR, 1H NMR and
Mass spectroscopy in order to confirm their formation. These
compounds were synthesized to screen for their antibacterial,
antifungal and antitubercular activities. The compounds were found
to be potent against Gram +ve, Gram -ve bacterial, fungal and H37Ra
strains. In the view of result the most active compounds are
carrying thiourea and its dominating urea derivatives.
A variety of novel pyrimidine, thiosemicarbazide and semicarbazide
derivatives have been reviewed. Based on brief review of compounds
will be subject to in vitro assessment for their antitumor and
antimicrobial activities, and compounds are believed to be the most
active members in this study. The tested compounds exhibit
excellent anticancer and antimicrobial activities against both
clinical cancer isolates and microbial pathogenic strains.
Quinazoline is the main six-membered heterocyclic ring system
reported for their biological activities, compounds with multiple
pharmacophores, which bring together knowledge of a target with
understanding of the molecule types that might interact with the
target family. Robust, versatile and scalable chemistry must be
employed to accomplish the task. This characteristic feature of
quinazoline would make a good template for a lead generation
library. The current review article focuses on biological actions
done for various targets along with the brief description of the
targets.
A series of novel 2-(substituted
benzylidene)-7-(4-bromophenyl)-5-(furan-2-yl)-2H-thiazolo
3,2-a]pyrimidin-3(7H)-ones were synthesized by using established
methods and were characterized by IR, 1H NMR and Mass spectroscopy
in order to confirm their formation. These compounds were
synthesized to evaluate their antitubercular, antibacterial and
antifungal potency. Docking studies revealed the importance of
functional groups and its different biological action. They were
found to be potent against Mycobacterium tuberculosis H37Ra strain,
also potent against Gram +ve, Gram -ve and fungal strains
A series of
Ethyl-3-methyl-5-(substituted-phenyl)-6,7,8,9-tetrahydro-5H-thiazolo
2,3-b]quinazoline-2-carboxylate derivatives have been synthesize
from cyclohexanone and substituted benzaldehyde with the aim of
developing potential antimicrobials and antitubercular agents. It
was characterized by FT-IR, 1H NMR and Mass spectroscopy. All the
newly synthesized compounds were screened for their antimicrobial
and antifungal activities on Staphylococcus aureus, Staphylococcus
epidermidis, Micrococcus luteus, Bacillus cereus (Gram-positive
bacteria), Escherichia coli, Pseudomonas aeruginosa, Klebsiella
pneumonia (Gram-negative bacteria), Aspergillus fumigates, Candida
albicans (Fungi). All the synthesized compounds were also evaluated
for their antitubercular activity against Mycobacterium
tuberculosis strain H37Ra.
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