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Volumes in the Proven Synthetic Methods Series address the concerns
many chemists have regarding irreproducibility of synthetic
protocols, lack of identification and characterization data for new
compounds, and inflated yields reported in chemical
communications-trends that have recently become a serious problem.
Exploring carbohydrate chemistry from both the academic and
industrial points of view, this unique resource brings together
useful information into one convenient reference. The series is
unique among other synthetic literature in the carbohydrate field
in that, to ensure reproducibility, an independent checker has
verified the experimental parts involved by repeating the protocols
or using the methods. Featuring contributions from world-renowned
experts and overseen by a highly respected series editor, this
latest volume compiles reliable protocols for the preparation of
intermediates for carbohydrate synthesis or other uses in the
glycosciences. Key Features: Explains reliable and tested protocols
for the preparation of intermediates for carbohydrate synthesis
Offers a unique resource in glycosciences, compiling useful
information in one reference Presents protocols that are of wide
use to a broad range of readers in the carbohydrate field and the
life sciences, including undergraduates taking carbohydrate
workshops Explores synthetic carbohydrate chemistry from both the
academic and industrial points of view Guarantees the reader a
good, clean, reproducible experiment
Volumes in the Proven Synthetic Methods Series address the concerns
many chemists have regarding irreproducibility of synthetic
protocols, lack of identification and characterization data for new
compounds, and inflated yields reported in chemical
communications-trends that have recently become a serious problem.
Exploring carbohydrate chemistry from both the academic and
industrial points of view, this unique resource brings together
useful information into one convenient reference. The series is
unique among other synthetic literature in the carbohydrate field
in that, to ensure reproducibility, an independent checker has
verified the experimental parts involved by repeating the protocols
or using the methods. Featuring contributions from world-renowned
experts and overseen by a highly respected series editor, this
latest volume compiles reliable protocols for the preparation of
intermediates for carbohydrate synthesis or other uses in the
glycosciences. Key Features: Explains reliable and tested protocols
for the preparation of intermediates for carbohydrate synthesis
Offers a unique resource in glycosciences, compiling useful
information in one reference Presents protocols that are of wide
use to a broad range of readers in the carbohydrate field and the
life sciences, including undergraduates taking carbohydrate
workshops Explores synthetic carbohydrate chemistry from both the
academic and industrial points of view Guarantees the reader a
good, clean, reproducible experiment
Many pathogens and aberrant malignant cells express unique
carbohydrates on their surface representing attractive targets for
vaccine design. Considerable progress has recently been made in the
identification of novel carbohydrate based vaccines and a large
number has reached clinical phase studies. The success of several
licensed carbohydrate based vaccines against bacterial pathogens
such as Haemophilus influenzae type b, Neisseria meningitidis or
Streptococcus pneumoniae demonstrates their great potential.
However, the study of anti-carbohydrate antibodies is technically
challenging and partly because of low affinities and promiscuous
specificity they have not been medically exploited to full
potential. The study of antibody specificities and identification
of protective carbohydrate epitopes lies at the heart of successful
vaccine design. In addition to therapy, antibodies in general serve
as diagnostic tools in medical and scientific laboratories. In this
setting high affinity and exquisite specificity are important
factors for their successful use. "Anticarbohydrate Antibodies -
from molecular basis to clinical application" compiles current
knowledge on the immunological recognition of carbohydrates by the
adaptive immune system from a molecular perspective providing
fundamental insight needed for advancing clinically relevant
diagnostics and therapeutic applications. Based on significant
progress in the fields of glycoimmunology and structural biology in
recent years, the book comprehensively reviews the state-of-the-art
in defining the key elements of carbohydrate recognition by
antibodies, the molecular mimicry of carbohydrate epitopes as well
as the molecular features leading to specific and relaxed binding
modes. Backed-up by a combination of modern technologies to
elucidate structural details of carbohydrate-antibody interactions,
biomedically important carbohydrate antigens from viral, bacterial,
parasite, insect and tumor cells have been analyzed in in-depth
reviews written by well-known experts in the field. Fundamental
knowledge of these molecular mechanisms eventually provides a
rational basis to improve efficacy of carbohydrate-based vaccines
and to further refine diagnostic tools in detection of pathogens
and malignant cells.
Many pathogens and aberrant malignant cells express unique
carbohydrates on their surface representing attractive targets for
vaccine design. Considerable progress has recently been made in the
identification of novel carbohydrate based vaccines and a large
number has reached clinical phase studies. The success of several
licensed carbohydrate based vaccines against bacterial pathogens
such as Haemophilus influenzae type b, Neisseria meningitidis or
Streptococcus pneumoniae demonstrates their great potential.
However, the study of anti-carbohydrate antibodies is technically
challenging and partly because of low affinities and promiscuous
specificity they have not been medically exploited to full
potential. The study of antibody specificities and identification
of protective carbohydrate epitopes lies at the heart of successful
vaccine design. In addition to therapy, antibodies in general serve
as diagnostic tools in medical and scientific laboratories. In this
setting high affinity and exquisite specificity are important
factors for their successful use. "Anticarbohydrate Antibodies -
from molecular basis to clinical application" compiles current
knowledge on the immunological recognition of carbohydrates by the
adaptive immune system from a molecular perspective providing
fundamental insight needed for advancing clinically relevant
diagnostics and therapeutic applications. Based on significant
progress in the fields of glycoimmunology and structural biology in
recent years, the book comprehensively reviews the state-of-the-art
in defining the key elements of carbohydrate recognition by
antibodies, the molecular mimicry of carbohydrate epitopes as well
as the molecular features leading to specific and relaxed binding
modes. Backed-up by a combination of modern technologies to
elucidate structural details of carbohydrate-antibody interactions,
biomedically important carbohydrate antigens from viral, bacterial,
parasite, insect and tumor cells have been analyzed in in-depth
reviews written by well-known experts in the field. Fundamental
knowledge of these molecular mechanisms eventually provides a
rational basis to improve efficacy of carbohydrate-based vaccines
and to further refine diagnostic tools in detection of pathogens
and malignant cells.
Carbohydrate chemistry provides access to carbohydrate-based
natural products and synthetic molecules as useful biologically
active structures relevant to many health care and disease-related
biological processes. Recent Trends in Carbohydrate Chemistry:
Synthesis, Structure, and Function of Carbohydrates covers green
and sustainable reactions, organometallic carbohydrate chemistry,
synthesis of glycomimetics, multicomponent reactions, and chemical
transformations leading to molecular diversity based on
carbohydrates. These include inhibitors of glycogen phosphorylase,
which are relevant in controlling type 2 diabetes and sugar
sulfates. Polysaccharides, which are commonly modified chemically,
are also examined with contributions covering polysaccharide
synthesis and modification of polysaccharides to obtain new
structures and properties. Recent Trends in Carbohydrate Chemistry:
Synthesis, Structure, and Function of Carbohydrates is ideal for
researchers working as synthetic organic chemists, and for those
interested in biomolecular chemistry, green chemistry,
organometallic chemistry, and material chemistry in academia as
well as in industry
Recent Trends in Carbohydrate Chemistry: Synthesis and Biomedical
Applications of Glycans and Glycoconjugates covers biomedically
relevant bacterial cell wall carbohydrates including recent
findings on biosynthetic aspects, advances in the chemical assembly
of bacterial lipopolysaccharide fragments and teichoic acids, and
modern NMR approaches to unravel structural details. The first part
introduces and provides the relevant background for synthetic
glycoconjugate vaccines. The second section focuses on synthetic
carbohydrate-based vaccines of therapeutic potential that are
licensed or under development. This second volume of Recent Trends
in Carbohydrate Chemistry is ideal for researchers working as
synthetic organic chemists, as well as those interested in
glycoconjugation, protein chemists, immunologists, and
microbiologists, in academia as well as in industry.
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