Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

The complement system, first described more than a century ago, was for many years the ugly duckling of the immunology world, but no more. Complement in recent years has blossomed into a fascinating and fast moving field of immediate relevance to clinical scientists in fields as diverse as transplantation biology, virology, and inflammation. Despite its emergence from the shadows, complement retains an unwarranted reputation for being "difficult." This impression derives in large part from the superficially complicated nomenclature, a relic of the long and tortuous process of unraveling the system, of naming components in order of discovery rather than in a syst- atic manner. Once the barrier of nomenclature has been surmounted, then the true simplicity of the system becomes apparent. Complement comprises an activation system and a cytolytic system. The former has diverged to focus on complement to distinct targets-bacteria, - mune complexes, and others-so that texts now describe three activation pa- ways, closely related to one another, but each with some unique features. The cytolytic pathway is the same regardless of the activation process and kills cells by creating pores in the membrane. Complement plays an important role in killing bacteria and is essential for the proper handling of immune complexes. Problems occur when complement is activated in an inappropriate manner-the potent inflammation-inducing products of the cascade then cause unwanted tissue damage and destruction.

'All parents and would-be parents should read this book. It will change their lives.' Mary Ann Sieghart, journalist and bestselling author of The Authority Gap Lying awake one night after struggling to put his new-born son back to sleep, Paul Morgan-Bentley found himself desperately scrolling for parenting advice for new fathers. Soon, Paul picked up on a reoccurring narrative - compared to mums, dads were useless. Frustrated by this generalisation and determined every parent should have an equal role in raising their child, Paul decided this narrative needed to change. In this deeply personal experience of fatherhood and parenting alongside his husband, Paul delves into what it really means to share the parental load, and how you can achieve it. With a range of research from around the world, and conversations with leading scientists, The Equal Parent explores the truths behind the falsehoods and myths about parenting roles. This book will help give you the tools to achieve the parenting equality that will benefit everyone in your family: mothers, fathers and, most importantly, your children. A myth-busting must-read about creating parenting equality for fans of Caitlin Moran, The Danish Way of Parenting and The Book You Wish Your Parents Had Read. 'An essential interrogation of the inequities of modern parenting. This book will change the way you see your family.' Leah Hazard, Sunday Times bestselling author of Womb 'An important book - an antidote to the many misconceptions surrounding parenthood. Thoughtful and encouraging, it is an inspiring look at how parenting can be.' Catherine Cho, author of Inferno: A Memoir of Motherhood and Madness 'A fascinating and well-written journey... delightful... It's exactly the kind of parenting book I love. Highly recommended.' Jessica Joelle Alexander, author of The Danish Way of Parenting 'An incredible book on parenthood.' Ziauddin Yousafzai 'So validating... a brilliant book.' Sunday Times Style 'Incredible.' Pink News 'Completely fascinating.' The Observer 'A really valuable book, written with great insight and warmth.' Brian Viner, author and critic 'A fascinating deepdive into parenting roles.' Sun Fabulous Mag 'A timely, humane and very welcome read.' Sarah Blaffer Hrdy, author of Mother Nature and Mothers and Others 'Funny, tender and insightful.' Metro 'Absolutely THE read... a timely conversation about what constitutes an equally parenting scenario.' Goodreads reviewer 'Fascinating and captivating... Would highly recommend, especially for new parents.' Goodreads reviewer

Tells the story of the British & Irish Lions momentous 2005 tour to New Zealand. From the selection of the players in April through to the final match in Auckland in July, readers will relive the excitement of Rugby's ultimate test. The players' themselves will tell the story of the tour through a series of interviews.

The complement system, first described more than a century ago, was for many years the ugly duckling of the immunology world, but no more. Complement in recent years has blossomed into a fascinating and fast moving field of immediate relevance to clinical scientists in fields as diverse as transplantation biology, virology, and inflammation. Despite its emergence from the shadows, complement retains an unwarranted reputation for being "difficult." This impression derives in large part from the superficially complicated nomenclature, a relic of the long and tortuous process of unraveling the system, of naming components in order of discovery rather than in a syst- atic manner. Once the barrier of nomenclature has been surmounted, then the true simplicity of the system becomes apparent. Complement comprises an activation system and a cytolytic system. The former has diverged to focus on complement to distinct targets-bacteria, - mune complexes, and others-so that texts now describe three activation pa- ways, closely related to one another, but each with some unique features. The cytolytic pathway is the same regardless of the activation process and kills cells by creating pores in the membrane. Complement plays an important role in killing bacteria and is essential for the proper handling of immune complexes. Problems occur when complement is activated in an inappropriate manner-the potent inflammation-inducing products of the cascade then cause unwanted tissue damage and destruction.

Relaunched in 2006 this edition includes: all the facts and figures from the major international competitions, such as the Six Nations, Tri Nations, World Sevens Series, Women's Rugby World Cup and Americas and Asian tournaments; a review of the season and feature articles on key issues in the game over the past year by the world's leading rugby writers; and a preview of the 2007 World Cup in France, as well as fixtures for the 2007 season.

From small beginnings in the early 1970s, the study of complement regulatory proteins has grown in the last decade to the point where it dominates the complement field. This growth has been fueled by the discovery of new regulators, the cloning of old and new regulators, the discovery that many of the regulators are structurally and evolutionarily related to each other and the development of recombinant forms for use in therapy. There are now more proteins known to be involved in controlling the complement system than there are components of the system and the list continues to grow. The time is ripe for a comprehensive review of our current knowledge of these intriguing proteins. This book does just that. The first few chapters discuss the "nuts-and-bolts" of the complement regulators, describing their structures, functional roles and modes of action. The roles of the complement regulators "in vivo" are then described, focusing on the consequences of deficiency, roles in the reproductive system, interactions with pathogens and exploitation for therapy. The interesting developments in defining the complement regulators expressed in other species are also discussed. The book is written as a monograph, albeit by two people. The text is as readable as possible without compromising on scientific accuracy and completeness. The conversational style very evident in some sections is deliberate Placing all references in a single bibliography at the end of the text further improves readability. The reader will go to the book to discover a specific fact but be persuaded to read more and derive pleasure from the process. The authors' enthusiasm for the subject comes over strongly in the text, and this enthusiasm proves infectious.
Key Features
* Complement regulators--structure, functional roles and mode of action
* Comprehensive reviews of each of the individual regulators
* Roles of Complement regulators "in vivo, "in health and disease:
* Consequences of deficiency
* Roles in the reproductive system
* Interactions with pathogens
* Exploitation for therapy
* Complement regulators in other species

Bumper Rugby World Cup edition of the acclaimed IRB World Rugby Yearbook, the ever-popular and utterly comprehensive review of the rugby year. On sale barely a month after the trophy has been lifted at the 2011 Rugby World Cup in New Zealand, the IRB World Rugby Yearbook will include a comprehensive review of the tournament including analysis and comment from leading players and the game's best rugby writers. On top of that will be a complete round-up of world rugby in 2011, including complete statistical records for every World Cup nation, all-time rugby records and reviews of each of the major competitions in the oval ball game. The IRB World Rugby Yearbook is quite simply the most comprehensive rugby yearbook on the planet.

Learn from Paul How to Open your Restaurant ... in 30 minutes or less He delivers the information In a simple format Using a medium that you are comfortable with To the point In a way you'll find interesting and entertaining He has learned that there is a lot of information out there for new restaurant owners - but little of it is either current or more importantly relevant. Paul has the information that will Save you money and Make you successful.