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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Complement Methods and Protocols (Paperback, Softcover reprint of hardcover 1st ed. 2000)
Loot Price: R4,004
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Complement Methods and Protocols (Paperback, Softcover reprint of hardcover 1st ed. 2000)
Series: Methods in Molecular Biology, 150
Expected to ship within 18 - 22 working days
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The complement system, first described more than a century ago, was
for many years the ugly duckling of the immunology world, but no
more. Complement in recent years has blossomed into a fascinating
and fast moving field of immediate relevance to clinical scientists
in fields as diverse as transplantation biology, virology, and
inflammation. Despite its emergence from the shadows, complement
retains an unwarranted reputation for being "difficult." This
impression derives in large part from the superficially complicated
nomenclature, a relic of the long and tortuous process of
unraveling the system, of naming components in order of discovery
rather than in a syst- atic manner. Once the barrier of
nomenclature has been surmounted, then the true simplicity of the
system becomes apparent. Complement comprises an activation system
and a cytolytic system. The former has diverged to focus on
complement to distinct targets-bacteria, - mune complexes, and
others-so that texts now describe three activation pa- ways,
closely related to one another, but each with some unique features.
The cytolytic pathway is the same regardless of the activation
process and kills cells by creating pores in the membrane.
Complement plays an important role in killing bacteria and is
essential for the proper handling of immune complexes. Problems
occur when complement is activated in an inappropriate manner-the
potent inflammation-inducing products of the cascade then cause
unwanted tissue damage and destruction.
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