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Cardiac Remodeling and Failure (Hardcover, 2003 ed.): Pawan K. Singal, Ian M.C. Dixon, Lorrie A. Kirshenbaum, Naranjan S. Dhalla Cardiac Remodeling and Failure (Hardcover, 2003 ed.)
Pawan K. Singal, Ian M.C. Dixon, Lorrie A. Kirshenbaum, Naranjan S. Dhalla
R8,149 Discovery Miles 81 490 Ships in 12 - 17 working days

According to the World Health Report (2000 http:/ /www. who. int/whr), of the 55 million deaths worldwide in 1999, more than 16 million were secondary to car diovascular complications. With the prospect of world population increasing from the current level of 6 billion to 9 billion by the middle of this century, the burden of cardiac disease is going to increase astronomically. Furthermore, scientists are being challenged not only to reduce mortality, but also to improve quality of life. Thus, more than ever, intellectuals from different disciplines including biology, sociology, informatics and health care have to join forces to meet the mandate. The World Heart Congress with a focus on "Frontiers in Cardiovascular Health" held in Winnipeg during July 6-11, 2001, made a unique attempt to bring these specialists together to brainstorm and map out the course of action for cardiovascular research and health in the next century. Anytime there is a relative increase in the workload on the heart, there are adap tive myocardial as well as humoral responses. When these adaptations or remodel ing at the organ, subcellular or gene level, become inadequate for a proper tissue perfusion, the condition of heart failure ensues. Prevention of the factors leading to the relative increase in workload as well as a better understanding of the adap tive responses and their failure are some of the hopes to combat the morbidity and mortality due to heart failure.

Mechanisms of Heart Failure (Hardcover, 1995 ed.): Pawan K. Singal, Ian M.C. Dixon, Robert E. Beamish, Naranjan S. Dhalla Mechanisms of Heart Failure (Hardcover, 1995 ed.)
Pawan K. Singal, Ian M.C. Dixon, Robert E. Beamish, Naranjan S. Dhalla
R5,708 Discovery Miles 57 080 Ships in 10 - 15 working days

Mechanisms of Heart Failure is based on papers selected from poster presentations made at the International Conference on Heart Failure, Winnipeg, May 20-23, 1994. Although the entire book is one continuous discussion of subcellular mechanisms of heart failure and its treatment, the presentation has been divided into three sections: the opening section on the subcellular basis of heart failure includes discussions of cytokines, signal transduction, metabolism, extracellular matrix, organ level changes and newer approaches to understanding the pathogenesis of heart failure. The second section focuses on the pathophysiological aspects of cardiomyopathies and their treatment. In the final section, medical, surgical and pharmacological approaches to the treatment of heart failure are discussed in clinical and animal laboratory settings.

Pathophysiology of Heart Failure (Hardcover, 1996 ed.): Naranjan S. Dhalla, Pawan K. Singal, Nobuakira Takeda, Robert E. Beamish Pathophysiology of Heart Failure (Hardcover, 1996 ed.)
Naranjan S. Dhalla, Pawan K. Singal, Nobuakira Takeda, Robert E. Beamish
R7,712 Discovery Miles 77 120 Ships in 10 - 15 working days

Pathophysiology of Heart Failure brings together leading basic scientists and clinicians, presenting new approaches to this complex problem, involving cardiomyopathic processes and ischemia perfusion injury. The result is a synthesis of state-of-the-art information on molecular biology, cellular physiology and structure-function relationships in the cardiovascular system. The role which excess intracellular calcium plays in the genesis of cardiac dysfunction is described as a fundamental mechanism underlying heart failure; one which may lead to improved prevention and treatment. Audience: Clinical and experimental cardiologists will find the book a helpful source of ideas and inspiration.

Frontiers in Cardiovascular Health (Hardcover, 2003 ed.): Naranjan S. Dhalla, Arun Chockalingam, H. Ivan Berkowitz, Pawan K.... Frontiers in Cardiovascular Health (Hardcover, 2003 ed.)
Naranjan S. Dhalla, Arun Chockalingam, H. Ivan Berkowitz, Pawan K. Singal
R4,313 Discovery Miles 43 130 Ships in 12 - 17 working days

The Frontiers in Cardiovascular Health varies between and within nations, depend ing upon the level at which the battle is fought for better cardiovascular health. According to the 1997 World Health Report, 15 million deaths (i. e. 30% of the total number of deaths) were attributable to cardiovascular diseases and this number is on the rise. The projection for the year 2020 is quite alarming with an expected cardiovascular mortality reaching 50 million. Much of this burden is projected to occur in developing countries, more specifically in the most populous countries of the world, namely China and India. These countries are already burdened with infectious and parasitic diseases and are trying to eradicate such diseases. With increasing life expectancies people all over the world, especially in developing coun tries, are exposed to degenerative atherosclerosis resulting in increased cardiovascu lar mortality and morbidity. In developing countries, resources available for health care are very limited. For example many of the African countries spend less than $10 per person per year on his/her entire health care let alone cardiovascular health. The average health care budget for nearly two thirds of the global population is well below $100 per year, on a per capita basis. Therefore, in developing countries health promotion and primary prevention are the frontiers by necessity. Improving awareness and health education is not only a matter of choice but is an absolute necessity.

Oxygen Radicals in the Pathophysiology of Heart Disease (Hardcover, 1988 ed.): Pawan K. Singal Oxygen Radicals in the Pathophysiology of Heart Disease (Hardcover, 1988 ed.)
Pawan K. Singal
R4,339 Discovery Miles 43 390 Ships in 12 - 17 working days

Over two centuries ago, oxygen was discovered as "air vital" the component of the earth's atmosphere necessary for life. Less than five years after this discovery, it was found that oxygen was both a life-sustaining and life threatening inhalant as it plays a role in the two extremes of the animal kingdom: life and death. In the subse quent years, we have made major strides in understanding the role of oxygen in maintaining life and volumes of information are now available on this topic. Our knowledge of the contribution of oxygen in cellular dysfunction and cell death which for the most part had lagged behind has begun to catch up. The deleterious ef fects of oxygen radicals and activated oxygen species on a variety of biological systems have now been described. Recently attention has also been focused on the toxic effects of oxygen on the cardiovascular system. The major aim of the present treatise is to offer an integrated view of the pathophysiological aspects of oxygen toxicity in the heart and blood vessels coupled with a review of therapeutic approaches (hopes?) with free radical scavengers and antioxidants. Internationally known expert investigators provide a concise and critical review on the topic of their expertise which also contains data from their own research."

Pathophysiology of Heart Disease - Proceedings of the Symposium held at the Eighth Annual Meeting of the American Section of... Pathophysiology of Heart Disease - Proceedings of the Symposium held at the Eighth Annual Meeting of the American Section of the International Society for Heart Research, July 8-11, 1986, Winnipeg, Canada (Hardcover, 1987 ed.)
Naranjan S. Dhalla, Pawan K. Singal, Robert E. Beamish
R5,486 Discovery Miles 54 860 Ships in 10 - 15 working days

It is indeed ironical that in the absence of a complete knowledge of Pathophysiology, clinical cardiologists are left with no choice but to do the best they can to help the patient with the armamentarium of drugs at their disposal. But nothing could be further from truth than to treat the diagnosed end point of a disease process without a full understanding of its patho physiology. This point was eloquently made by Dr. Arnold Katz in his Presidential Address (Chapter 1) at the 8th Annual Meeting of the American Section of the International Society for Heart Research held in Winnipeg, Canada, July 8-11, 1986. This volume represents a part of the scientific proceedings of this Meeting. From a reading of this treatise it will become evident that discoveries of newer scientific facts as well as a better understanding of pathophysiology are continuously influencing/ improving our therapeutic approaches in modern medicine. In this book, latest biochemical, physiological and pharmacological findings on different experimental models such as Myocaridal hypertrophy, Hypertension and heart failure, Diabetes, Cardio myopathies and Cardiac function in shock are described by internationally recognised experts. Hopefully information presented here will provide another building block to the edifice of Science of Cardiology which we all are trying to create. Acknowledgements We are grateful to the following Agencies and Foundations for their generous financial support of the Symposium, which formed the basis of this book. A. Major Contributors: 1. Manitoba Heart Foundation 2. Sterling-Winthrop Research Institute 3. Squibb Canada, Inc."

Diabetes and Cardiovascular Disease - Etiology, Treatment, and Outcomes (Hardcover, 2001 ed.): Aubie Angel, Naranjan S. Dhalla,... Diabetes and Cardiovascular Disease - Etiology, Treatment, and Outcomes (Hardcover, 2001 ed.)
Aubie Angel, Naranjan S. Dhalla, Grant N. Pierce, Pawan K. Singal
R4,356 Discovery Miles 43 560 Ships in 12 - 17 working days

Diabetes and cardiovascular disease together account for the largest portion of health care spending compared to all other diseases in Western society. This work seeks to provide an understanding of the causes of diabetes and its cardiovascular complications. As this understanding becomes more widely appreciated, it will serve as a foundation for evidence-based care and wider acceptance of sound science. The International Conference on Diabetes and Cardiovascular Disease, held in Winnipeg, in June 1999, was organized to bring together a multi-disciplinary group of researchers dedicated to further knowledge amongst researchers, care givers, and the managers of the health system. The invited speakers submitted their works for publication, which serves as the basis for this book. Major themes include: epidemiology of diabetes mellitus, metabolic risk factors in diabetes and cardiovascular disease, hypertension in diabetes mellitus, cardiac function in diabetes, glycemic control and improved cardiovascular function, diabetes management, and endothelial function in diabetes.

Signal Transduction and Cardiac Hypertrophy (Hardcover, 2003 ed.): Naranjan S. Dhalla, Larry Hryshko, Elissavet Kardami, Pawan... Signal Transduction and Cardiac Hypertrophy (Hardcover, 2003 ed.)
Naranjan S. Dhalla, Larry Hryshko, Elissavet Kardami, Pawan K. Singal
R5,735 Discovery Miles 57 350 Ships in 10 - 15 working days

Cellular signaling in cardiac muscle refers to the myriad of stimuli and responses that direct and control the physiological operation of this organ. Our understand ing of these complex signaling cascades has increased dramatically over the past few decades with the advent of molecular tools for their dissection. Moreover, this infor mation is beginning to provide tangible targets towards manipulating cardiac func tion in the setting of cardiovascular disease. The mechanisms and factors that regulate cardiac cell growth are of particular interest as both adaptive and maladaptive responses can occur during cardiac hypertrophy. Cardiac hypertrophy describes the increase in individual cardiac myocyte size that is accomplished through the series and/or parallel addition of sarcomeres. The ability of cardiac muscle to increase in size through hyperplasia becomes highly restricted or negligible shortly after birth. Consequently, the increase in heart size associated with development and growth of an individual occurs through hypertrophy. In response to a chronic increase in workload, cardiac muscle cells can dramatically increase in size to face their increasing contractile demands. While this plasticity is clearly a ben eficial response under many conditions, it can be highly deleterious and inappropri ate under others. For example, cardiac hypertrophy associated with endurance exercise clearly enhances athletic performance. In contrast, the hypertrophy associated with chronic hypertension, stenotic or regurgitant heart valves, or following a myocardial infarction often continues far beyond the period where this adaptive response is ben eficial."

Stress and Heart Disease - Proceedings of the International Symposium on Stress and Heart Disease, June 26-29, 1984 Winnipeg,... Stress and Heart Disease - Proceedings of the International Symposium on Stress and Heart Disease, June 26-29, 1984 Winnipeg, Canada (Hardcover, 1985 ed.)
R.E. Beamish, Pawan K. Singal, Naranjan S. Dhalla
R5,696 Discovery Miles 56 960 Ships in 10 - 15 working days

It has been known or suspected for centuries that there is an association between mind and emotions and the occurrence of heart disease apd sudden death. During the past fifty years this relationship has become identified with the concept of Stress, a notion developed and popularized by Hans Selye. In recent years there has been an upward surge of interest in stress by scientists in several disciplines and by the general public. Although, books, journal articles, seminars and media programs devoted to stress now abound, the definition, manifestations, mechanisms, and management of stress remain uncertain and controversial. In an attempt to clarify the situation an International Symposium on Stress and Heart Disease was held in Winnipeg, Canada, June 26-29, 1984, and the proceedings form the basis of this book and its companion volume "Patho genesis of Stress-Induced Heart Disease." Although most species which have ever existed are now extinct through countless millenia, the human species has successfully adapted to changing conditions ("stressors") such as ice ages, predators and parasites, wars, famine and plague, and now it is coping with rapidly changing social, economic and political circumstances. Such adaptation occurs at all levels of life- at the molecular level within the cell, at the level of the whole cell, in the groups of cells as organs, in the entire organism or individual, and in some cases, in the society in which the individual lives."

Frontiers in Cardiovascular Health (Paperback, Softcover reprint of the original 1st ed. 2003): Naranjan S. Dhalla, Arun... Frontiers in Cardiovascular Health (Paperback, Softcover reprint of the original 1st ed. 2003)
Naranjan S. Dhalla, Arun Chockalingam, H. Ivan Berkowitz, Pawan K. Singal
R4,322 Discovery Miles 43 220 Ships in 10 - 15 working days

The Frontiers in Cardiovascular Health varies between and within nations, depend ing upon the level at which the battle is fought for better cardiovascular health. According to the 1997 World Health Report, 15 million deaths (i. e. 30% of the total number of deaths) were attributable to cardiovascular diseases and this number is on the rise. The projection for the year 2020 is quite alarming with an expected cardiovascular mortality reaching 50 million. Much of this burden is projected to occur in developing countries, more specifically in the most populous countries of the world, namely China and India. These countries are already burdened with infectious and parasitic diseases and are trying to eradicate such diseases. With increasing life expectancies people all over the world, especially in developing coun tries, are exposed to degenerative atherosclerosis resulting in increased cardiovascu lar mortality and morbidity. In developing countries, resources available for health care are very limited. For example many of the African countries spend less than $10 per person per year on his/her entire health care let alone cardiovascular health. The average health care budget for nearly two thirds of the global population is well below $100 per year, on a per capita basis. Therefore, in developing countries health promotion and primary prevention are the frontiers by necessity. Improving awareness and health education is not only a matter of choice but is an absolute necessity.

The Cellular Basis of Cardiovascular Function in Health and Disease (Paperback, Softcover reprint of the original 1st ed.... The Cellular Basis of Cardiovascular Function in Health and Disease (Paperback, Softcover reprint of the original 1st ed. 1997)
Pawan K. Singal, Vincenzo Panagia, Grant N. Pierce
R8,165 Discovery Miles 81 650 Ships in 10 - 15 working days

This special issue of Molecular and Cellular Biochemistry contains original research articles and review papers which were invited from the participants of a recent meeting organized to honour the 60th birthday of Naranjan S. Dhalla, Ph.D., M.D.(Hon.). The meeting, organized by Drs. Morris Karmazyn (London), Grant Pierce (Winnipeg) and Balwant Tuana (Ottawa), was held at the Best Western Lakeside Inn in Kenora, Ontario, Canada on August 23-25, 1996. The meeting was entitled The Cellular Basis of Cardiovascular Function in Health and Disease. There were over 40 invited speakers from 15 different countries represented at the meeting, attended by over 280 people. Keynote lectures were presented by Drs. Norman Alpert (Burlington, VT), Robert Jennings (Chapel Hill, NC), Makoto Nagano (Tokyo, Japan), Howard Morgan (Danville, PA), John Solaro (Chicago, IL) and Nobuskira Takeda (Tokyo, Japan). Dr. Henry Friesen, President of the Medical Research Council of Canada, presented Dr. Dhalla with a plaque at the banquet honouring his research accomplishments over his distinguished career. Dr.Dhalla's outstanding research achievements in understanding the subcellular basis of cardiovascular disease were highlighted at the meeting. One of the unique aspects of the meeting was the special effort made by 39 former trainees of Dr. Dhalla to attend the meeting to honour their mentor. The ex-students and trainees came from all over Canada, the United States, Japan, Slovakia, Germany, the Czech Republic, Estonia and the Netherlands. The meeting was judged to be an overwhelming success in terms of the scientific content as well as collaborative interactions initiated.

Biochemistry of Hypertrophy and Heart Failure (Paperback, Softcover reprint of the original 1st ed. 2003): Lorrie A.... Biochemistry of Hypertrophy and Heart Failure (Paperback, Softcover reprint of the original 1st ed. 2003)
Lorrie A. Kirshenbaum, Ian M.C. Dixon, Pawan K. Singal
R2,788 Discovery Miles 27 880 Ships in 10 - 15 working days

The focus of this special issue of Molecular and Cellular Biochemistry is underlying mechanisms that regulate cardiac growth. The new information provided in this special issue can be utilized to design new treatment modalities that will reduce the incidence of cardiac failure which will improve quality of life in patients with chronic heart disease.

Signal Transduction and Cardiac Hypertrophy (Paperback, Softcover reprint of the original 1st ed. 2003): Naranjan S. Dhalla,... Signal Transduction and Cardiac Hypertrophy (Paperback, Softcover reprint of the original 1st ed. 2003)
Naranjan S. Dhalla, Larry Hryshko, Elissavet Kardami, Pawan K. Singal
R5,497 Discovery Miles 54 970 Ships in 10 - 15 working days

Cellular signaling in cardiac muscle refers to the myriad of stimuli and responses that direct and control the physiological operation of this organ. Our understand ing of these complex signaling cascades has increased dramatically over the past few decades with the advent of molecular tools for their dissection. Moreover, this infor mation is beginning to provide tangible targets towards manipulating cardiac func tion in the setting of cardiovascular disease. The mechanisms and factors that regulate cardiac cell growth are of particular interest as both adaptive and maladaptive responses can occur during cardiac hypertrophy. Cardiac hypertrophy describes the increase in individual cardiac myocyte size that is accomplished through the series and/or parallel addition of sarcomeres. The ability of cardiac muscle to increase in size through hyperplasia becomes highly restricted or negligible shortly after birth. Consequently, the increase in heart size associated with development and growth of an individual occurs through hypertrophy. In response to a chronic increase in workload, cardiac muscle cells can dramatically increase in size to face their increasing contractile demands. While this plasticity is clearly a ben eficial response under many conditions, it can be highly deleterious and inappropri ate under others. For example, cardiac hypertrophy associated with endurance exercise clearly enhances athletic performance. In contrast, the hypertrophy associated with chronic hypertension, stenotic or regurgitant heart valves, or following a myocardial infarction often continues far beyond the period where this adaptive response is ben eficial.

Diabetes and Cardiovascular Disease - Etiology, Treatment, and Outcomes (Paperback, Softcover reprint of the original 1st ed.... Diabetes and Cardiovascular Disease - Etiology, Treatment, and Outcomes (Paperback, Softcover reprint of the original 1st ed. 2001)
Aubie Angel, Naranjan S. Dhalla, Grant N. Pierce, Pawan K. Singal
R4,299 Discovery Miles 42 990 Ships in 10 - 15 working days

Diabetes and cardiovascular disease together account for the largest portion of health care spending compared to all other diseases in Western society. This work seeks to provide an understanding of the causes of diabetes and its cardiovascular complications. As this understanding becomes more widely appreciated, it will serve as a foundation for evidence-based care and wider acceptance of sound science. The International Conference on Diabetes and Cardiovascular Disease, held in Winnipeg, in June 1999, was organized to bring together a multi-disciplinary group of researchers dedicated to further knowledge amongst researchers, care givers, and the managers of the health system. The invited speakers submitted their works for publication, which serves as the basis for this book. Major themes include: epidemiology of diabetes mellitus, metabolic risk factors in diabetes and cardiovascular disease, hypertension in diabetes mellitus, cardiac function in diabetes, glycemic control and improved cardiovascular function, diabetes management, and endothelial function in diabetes.

Mechanisms of Heart Failure (Paperback, Softcover reprint of the original 1st ed. 1995): Pawan K. Singal, Ian M.C. Dixon,... Mechanisms of Heart Failure (Paperback, Softcover reprint of the original 1st ed. 1995)
Pawan K. Singal, Ian M.C. Dixon, Robert E. Beamish, Naranjan S. Dhalla
R5,483 Discovery Miles 54 830 Ships in 10 - 15 working days

Mechanisms of Heart Failure is based on papers selected from poster presentations made at the International Conference on Heart Failure, Winnipeg, May 20-23, 1994. Although the entire book is one continuous discussion of subcellular mechanisms of heart failure and its treatment, the presentation has been divided into three sections: the opening section on the subcellular basis of heart failure includes discussions of cytokines, signal transduction, metabolism, extracellular matrix, organ level changes and newer approaches to understanding the pathogenesis of heart failure. The second section focuses on the pathophysiological aspects of cardiomyopathies and their treatment. In the final section, medical, surgical and pharmacological approaches to the treatment of heart failure are discussed in clinical and animal laboratory settings.

Stress and Heart Disease - Proceedings of the International Symposium on Stress and Heart Disease, June 26-29, 1984 Winnipeg,... Stress and Heart Disease - Proceedings of the International Symposium on Stress and Heart Disease, June 26-29, 1984 Winnipeg, Canada (Paperback, Softcover reprint of the original 1st ed. 1985)
R.E. Beamish, Pawan K. Singal, Naranjan S. Dhalla
R5,477 Discovery Miles 54 770 Ships in 10 - 15 working days

It has been known or suspected for centuries that there is an association between mind and emotions and the occurrence of heart disease apd sudden death. During the past fifty years this relationship has become identified with the concept of Stress, a notion developed and popularized by Hans Selye. In recent years there has been an upward surge of interest in stress by scientists in several disciplines and by the general public. Although, books, journal articles, seminars and media programs devoted to stress now abound, the definition, manifestations, mechanisms, and management of stress remain uncertain and controversial. In an attempt to clarify the situation an International Symposium on Stress and Heart Disease was held in Winnipeg, Canada, June 26-29, 1984, and the proceedings form the basis of this book and its companion volume "Patho genesis of Stress-Induced Heart Disease". Although most species which have ever existed are now extinct through countless millenia, the human species has successfully adapted to changing conditions ("stressors") such as ice ages, predators and parasites, wars, famine and plague, and now it is coping with rapidly changing social, economic and political circumstances. Such adaptation occurs at all levels of life- at the molecular level within the cell, at the level of the whole cell, in the groups of cells as organs, in the entire organism or individual, and in some cases, in the society in which the individual lives.

Pathophysiology of Heart Failure (Paperback, Softcover reprint of the original 1st ed. 1996): Naranjan S. Dhalla, Pawan K.... Pathophysiology of Heart Failure (Paperback, Softcover reprint of the original 1st ed. 1996)
Naranjan S. Dhalla, Pawan K. Singal, Nobuakira Takeda, Robert E. Beamish
R4,322 Discovery Miles 43 220 Ships in 10 - 15 working days

Pathophysiology of Heart Failure brings together leading basic scientists and clinicians, presenting new approaches to this complex problem, involving cardiomyopathic processes and ischemia perfusion injury. The result is a synthesis of state-of-the-art information on molecular biology, cellular physiology and structure-function relationships in the cardiovascular system. The role which excess intracellular calcium plays in the genesis of cardiac dysfunction is described as a fundamental mechanism underlying heart failure; one which may lead to improved prevention and treatment. Audience: Clinical and experimental cardiologists will find the book a helpful source of ideas and inspiration.

Cardiac Remodeling and Failure (Paperback, Softcover reprint of the original 1st ed. 2003): Pawan K. Singal, Ian M.C. Dixon,... Cardiac Remodeling and Failure (Paperback, Softcover reprint of the original 1st ed. 2003)
Pawan K. Singal, Ian M.C. Dixon, Lorrie A. Kirshenbaum, Naranjan S. Dhalla
R8,145 Discovery Miles 81 450 Ships in 10 - 15 working days

According to the World Health Report (2000 http:/ /www. who. int/whr), of the 55 million deaths worldwide in 1999, more than 16 million were secondary to car diovascular complications. With the prospect of world population increasing from the current level of 6 billion to 9 billion by the middle of this century, the burden of cardiac disease is going to increase astronomically. Furthermore, scientists are being challenged not only to reduce mortality, but also to improve quality of life. Thus, more than ever, intellectuals from different disciplines including biology, sociology, informatics and health care have to join forces to meet the mandate. The World Heart Congress with a focus on "Frontiers in Cardiovascular Health" held in Winnipeg during July 6-11, 2001, made a unique attempt to bring these specialists together to brainstorm and map out the course of action for cardiovascular research and health in the next century. Anytime there is a relative increase in the workload on the heart, there are adap tive myocardial as well as humoral responses. When these adaptations or remodel ing at the organ, subcellular or gene level, become inadequate for a proper tissue perfusion, the condition of heart failure ensues. Prevention of the factors leading to the relative increase in workload as well as a better understanding of the adap tive responses and their failure are some of the hopes to combat the morbidity and mortality due to heart failure.

Oxygen Radicals in the Pathophysiology of Heart Disease (Paperback, Softcover reprint of the original 1st ed. 1988): Pawan K.... Oxygen Radicals in the Pathophysiology of Heart Disease (Paperback, Softcover reprint of the original 1st ed. 1988)
Pawan K. Singal
R4,249 Discovery Miles 42 490 Ships in 10 - 15 working days

Over two centuries ago, oxygen was discovered as "air vital" the component of the earth's atmosphere necessary for life. Less than five years after this discovery, it was found that oxygen was both a life-sustaining and life threatening inhalant as it plays a role in the two extremes of the animal kingdom: life and death. In the subse quent years, we have made major strides in understanding the role of oxygen in maintaining life and volumes of information are now available on this topic. Our knowledge of the contribution of oxygen in cellular dysfunction and cell death which for the most part had lagged behind has begun to catch up. The deleterious ef fects of oxygen radicals and activated oxygen species on a variety of biological systems have now been described. Recently attention has also been focused on the toxic effects of oxygen on the cardiovascular system. The major aim of the present treatise is to offer an integrated view of the pathophysiological aspects of oxygen toxicity in the heart and blood vessels coupled with a review of therapeutic approaches (hopes?) with free radical scavengers and antioxidants. Internationally known expert investigators provide a concise and critical review on the topic of their expertise which also contains data from their own research."

Catecholamines and Heart Disease (Hardcover, New): Pallab K. Ganguly Catecholamines and Heart Disease (Hardcover, New)
Pallab K. Ganguly; Contributions by Robert E. Beamish, John H. McNeill, Vincenzo Panagia, Heinz Rupp, …
R9,224 Discovery Miles 92 240 Ships in 12 - 17 working days

A concise, in-depth analysis of the status of the sympathetic system in heart diseases
This book summarizes the functional status of the sympathetic neural system in cardiological diseased states and highlights aspects of sympathetic neural activity that are important to an overall understanding of the pathophysiology process. Critical reviews of methods for evaluating sympathetic activity are discussed, existing data is closely scrutinized, and attempts are made to delineate the factors derived from increased sympathetic activity. The book provides a physiologically and clinically based approach to the investigation of the involvement of catecholamines in cardiovascular diseases, which makes it a valuable addition to the reference collections of researchers, clinical scientists, and graduate students.

Pathophysiology of Heart Disease - Proceedings of the Symposium held at the Eighth Annual Meeting of the American Section of... Pathophysiology of Heart Disease - Proceedings of the Symposium held at the Eighth Annual Meeting of the American Section of the International Society for Heart Research, July 8-11, 1986, Winnipeg, Canada (Paperback, Softcover reprint of the original 1st ed. 1987)
Naranjan S. Dhalla, Pawan K. Singal, Robert E. Beamish
R5,452 Discovery Miles 54 520 Out of stock

It is indeed ironical that in the absence of a complete knowledge of Pathophysiology, clinical cardiologists are left with no choice but to do the best they can to help the patient with the armamentarium of drugs at their disposal. But nothing could be further from truth than to treat the diagnosed end point of a disease process without a full understanding of its patho physiology. This point was eloquently made by Dr. Arnold Katz in his Presidential Address (Chapter 1) at the 8th Annual Meeting of the American Section of the International Society for Heart Research held in Winnipeg, Canada, July 8-11, 1986. This volume represents a part of the scientific proceedings of this Meeting. From a reading of this treatise it will become evident that discoveries of newer scientific facts as well as a better understanding of pathophysiology are continuously influencing/ improving our therapeutic approaches in modern medicine. In this book, latest biochemical, physiological and pharmacological findings on different experimental models such as Myocaridal hypertrophy, Hypertension and heart failure, Diabetes, Cardio myopathies and Cardiac function in shock are described by internationally recognised experts. Hopefully information presented here will provide another building block to the edifice of Science of Cardiology which we all are trying to create. Acknowledgements We are grateful to the following Agencies and Foundations for their generous financial support of the Symposium, which formed the basis of this book. A. Major Contributors: 1. Manitoba Heart Foundation 2. Sterling-Winthrop Research Institute 3. Squibb Canada, Inc.

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