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Treatment Landscape of Targeted Therapies in Oncology: Challenges
and Opportunities provides up-to-date knowledge on
antitumor-targeted therapies and immunotherapy. The book's chapters
are written by researchers dynamically working/focusing on cancer
treatment. The content is designed to help those who are new to the
field (beginners) and various specialized scientists and
researchers involved in cancer research. For decades, the hallmark
of cancer treatment has been conventional chemotherapy. But with
the rapid increase in our understanding of the immune system, more
and more small molecules, peptides, recombinant antibodies,
vaccines and cellular therapeutic modalities are being applied to
manipulate the immune response for cancer treatment.
The book titled "Applications of Computational Intelligence
Techniques in Communications" is a one-stop platform for the
researchers, academicians, and people from industry to get a
thorough understanding of the latest research in the field of
communication engineering. Over the past decade, a manyfold
increase in the use of computational intelligence techniques has
been identified for obtaining the most optimal and timely solution
to a problem. The various aspects covering the significant
contribution of numerous computational intelligence techniques have
been discussed in detail in this book. Today’s era of machine
learning and Internet of Things (IoT) is demanding as high as
possible data rate which has resulted into tremendous increased
speed of communication. To match-up the pace, the computational
intelligence is posing to be the most efficient and favourite tool.
The book aims to cover the current technological advancements in
the field of communication engineering and give a detailed prospect
of computational intelligence to its readers. This book will be a
great support to the people working in the field of IoT, machine
learning, healthcare, optimization, filter design, 5G and beyond,
signal processing etc. The chapters included here will expose its
audience to various newly introduced and advanced computational
intelligence techniques applicable in communication domain. The
readers will be exposed multiple interdisciplinary areas of
research in communication and will get the motivation to work in
collaboration with other professionals from both the academia and
industry.
The Internet of Energy (IoE), with the integration of advanced
information and communication technologies (ICT), has led to a
transformation of traditional networks to smart systems. Internet
of Energy Handbook provides updated knowledge in the field of
energy management with an Internet of Things (IoT) perspective.
Features Explains the technological developments for energy
management leading to a reduction in energy consumption through
topics like smart energy systems, smart sensors, communication,
techniques, and utilization Includes dedicated sections covering
varied aspects related to renewable sources of energy, power
distribution, and generation Incorporates energy efficiency,
optimization, and sensor technologies Covers multidisciplinary
aspects in computational intelligence and IoT Discusses building
energy management aspects including temperature, humidity, the
number of persons involved, and light intensity This handbook is
aimed at graduate students, researchers, and professionals
interested in power systems, IoT, smart grids, electrical
engineering, and transmission.
This book details cutting edge technologies in micromanufacturing
processes, an industry which has undergone a technological
transformation in the past decade. Enabling engineers to create
high performance, low cost and long-lasting products, this book is
an essential companion to all those working in micro and nano
engineering. As products continue to get smaller and smaller, the
field of micromanufacturing has gained an international audience.
This book looks at both approaches of micromanufacturing: top-down
and bottom-up. The top-down approach includes subtractive
micromanufacturing processes such as microturning, micromilling,
microdrillling, laser beam micromachining and magnetic abrasive
finishing. The bottom-up approach involves additive manufacturing
processes such as microforming, micro deep drawing, microforging,
microextrusion, and microwelding. Additionally, microjoining and
microhybrid manufacturing processes are discussed in detail. The
book also aids engineers and students in solving common
manufacturing issues such as choice of materials and testing. The
book will be of interest to those working in micro and nano
engineering and machining, as well as students in manufacturing
engineering, materials science and more.
Membrane based PoU water treatment systems are preferred due to
shortcomings of other water treatment technologies. This system
works without the addition of chemicals, with relatively low energy
consumption, and easy and well-arranged process conductions. Hence,
there is an inevitable need to understand the basic operational
parameters, design and maintenance of membrane based PoU water
treatment systems. The book provides insight of membrane based PoU
water treatment systems (ultrafiltration, microfiltration,
nano-filtration, reverse osmosis etc.) including description of
physical, chemical, microbiological water contaminants and
conventional methods for their removal. This book also discusses
the limitations of conventional water treatment systems in
fulfilling PoU water demands in developing countries and evaluates
the suitability of membrane based treatment covering design,
operation, maintenance and techno-economic feasibility of PoU water
treatment system. The book covers issues related to water quality,
water contamination, reasons for recent water quality degradation,
conventional methods for water treatment –their limitations and
need for PoU water treatment systems. The first chapter explains
the contaminants in drinking water, sources and effects of these
contaminants, and importance of removal of these contaminants.
Second chapter describes various units, advantages and limitations
of conventional water treatment plant in addition to various
point-of-use water treatment technologies. Third chapter covers
detail about ultrafiltration, microfiltration, nanofiltration and
RO based PoU water treatment systems. Fourth chapter describes
design criteria, and design of pre-treatment and post-treatment and
multi-stage/multi-barrier systems. Modelling and simulation,
process optimization, material requirement and bill of materials
and more importantly fabrication aspects are included in Chapter 5.
Chapter 6 includes operation and maintenance aspects including that
of pre and post treatment units. Techno-economic aspects of
membrane based PoU systems are elucidated in seventh chapter. The
last chapter elaborates process of certification and evaluation.
The Internet of Energy (IoE), with the integration of advanced
information and communication technologies (ICT), has led to a
transformation of traditional networks to smart systems. Internet
of Energy Handbook provides updated knowledge in the field of
energy management with an Internet of Things (IoT) perspective.
Features Explains the technological developments for energy
management leading to a reduction in energy consumption through
topics like smart energy systems, smart sensors, communication,
techniques, and utilization Includes dedicated sections covering
varied aspects related to renewable sources of energy, power
distribution, and generation Incorporates energy efficiency,
optimization, and sensor technologies Covers multidisciplinary
aspects in computational intelligence and IoT Discusses building
energy management aspects including temperature, humidity, the
number of persons involved, and light intensity This handbook is
aimed at graduate students, researchers, and professionals
interested in power systems, IoT, smart grids, electrical
engineering, and transmission.
Stem Cells: An Alternative Therapy for COVID-19 and Cytokine Storm
provides mechanistic insights into the role of stem cells to combat
COVID-19 outbreak and other pathologies where cytokines storm is
the cause of concern for e.g., radiation exposure, multiple organ
failure and sepsis. There has been an increase in number of cases
of new diseases in the last decade, including mucormycosis, Zika
virus, H1N1 influenza virus, among others. These diseases can be
characterized by the induction of cytokine storm, which is mainly
responsible for morbidity and mortality. Stem cell therapy has
emerged as a potential treatment for viral diseases, including, but
not limited to, COVID-19. Interestingly, clinical trials in
patients with COVID-19 complications depicted faster recovery in
patients post mesenchymal stem cells therapy owing to the decreased
cytokines levels, anti-viral effects and regeneration of the
infected tissue.
The applications of biocomposite materials are increasing in
aerospace, automobile, and household items due to their
biodegradable, renewable, non-corrosion, and high strength to
weight ratio properties. The processing and characterization of
biofiber-reinforced biocomposite materials are vital for their
strength and performance. This book discusses the properties,
chemical treatment, and compatibility of biofibers with materials.
This book presents the selected peer-reviewed proceedings of the
International Conference on Innovative Engineering Design (ICOIED
2020). The contents provide a multidisciplinary approach for the
development of innovative product design and their benefits for the
society. The book presents latest advances in various fields like
design process, service development, micro/nano technology, sensors
and MEMS, and sustainability in engineering design. This book can
be useful for students, researchers, and professionals interested
in innovative product/process design and development.
This book presents the selected peer-reviewed proceedings of the
International Conference on Innovative Engineering Design (ICOIED
2020). The contents provide a multidisciplinary approach for the
development of innovative product design and their benefits for the
society. The book presents latest advances in various fields like
design process, service development, micro/nano technology, sensors
and MEMS, and sustainability in engineering design. This book can
be useful for students, researchers, and professionals interested
in innovative product/process design and development.
This book comprises selected proceedings of the International
Conference on Recent Advancements in Civil Engineering and
Infrastructural Developments (ICRACEID 2019). The contents are
broadly divided into five areas (i) smart transportation with urban
planning, (ii) clean energy and environment, (iii) water
distribution and waste management, (iv) smart materials and
structures, and (v) disaster management. The book aims to provide
solutions to global challenges using innovative and emerging
technologies covering various fields of civil engineering. The
major topics covered include urban planning, transportation, water
distribution, waste management, disaster management, environmental
pollution and control, environmental impact assessment, application
of GIS and remote sensing, and structural analysis and design.
Given the range of topics discussed, the book will be beneficial
for students, researchers as well industry professionals.
This book provides in-depth reviews of the role of Rhizobium in
agriculture and its biotechnological applications. Individual
chapters explore topics such as: the occurrence and distribution of
Rhizobium; phenotypic and molecular characteristics of Rhizobium;
impact of Rhizobium on other microbial communities in the
rhizosphere; N2-fixation ability of Rhizobium; Rhizobium and biotic
stress; Rhizobium-mediated restoration of an ecosystem; in silico
analysis of the rhizobia pool; further biotechnological
perspectives of Rhizobium.
Oxides for Medical Applications reviews the most important advances
of oxides with optical, magnetic and electronic properties for
biomedical applications. Owing to their unusual properties, oxides
are expected to play a significant role in the prevention or early
treatment of diseases. In addition to catalytically active
artificial enzymes based on oxide materials-the book provides
comprehensive coverage of the most relevant categories of oxide
materials and their properties and applications. Since magnetic
oxides are used extensively for a wide range of medical
applications, there are numerous chapters that address these
materials, including LSMO nanoparticles, ferrites, nanocatalysts,
and more. Finally, practical considerations for the translation of
these materials from the lab to the clinic are reviewed, including
biocompatibility and toxicity of oxide nanoparticles, making this a
suitable resource for researchers and practitioners in materials
science and engineering in academia and the clinic.
Nanobioanalytical Approaches to Medical Diagnostics reviews a range
of nanobiomaterials and bioanalytical nano-devices for medical
diagnostics. Nanobiomaterials and nano-devices are used in various
bioanalytical and biochemical systems to provide real-time,
point-of-care diagnostics. The specialized properties of
nanoparticles allow them to be engineered and adapted to produce
the required effect within a bioanalytical or biochemical system -
offering targeted and detailed diagnostic results in a range of
biomedical applications. This book covers both traditional
biochemical and modern, combined nano-approaches to medical
diagnostics. Chapters detail a range of in vitro, in vivo and ex
vivo models for nanobioanalytics, including DNA and peptide-based,
erythrocyte, microfluidic and more. In addition, sections also look
at various different medical diagnostic applications, such as in
cancer detection, infectious disease diagnosis and blood glucose
sensing.
Novel Therapeutic Approaches Targeting Oxidative Stress
investigates the role of oxidative stress in disease and explores
the latest methods and approaches to targeting oxidative stress for
treatment and diagnosis. The book begins with an introduction to
oxidative stress and its significance. Subsequent sections cover
biochemical methods for detecting free radicals and novel
therapeutic approaches for targeting oxidative stress in a number
of different diseases. This includes age-related illnesses,
neuropsychiatric disorders such as schizophrenia and bipolar
disorder, and neurodegenerative diseases like Alzheimer's and
Parkinson's disease. Novel approaches for targeting oxidative
stress in cancer and cardiovascular diseases are also explored. The
book then moves on to discuss advances in drug delivery systems and
detecting oxidative stress biomarkers using biosensors. It
concludes with case studies that illustrate the targeting of
oxidative stress and future perspectives.
PGPR Amelioration in Sustainable Agriculture: Food Security and
Environmental Management explores the growth-promoting
rhizobacteria (PGPR) that are indigenous to soil and plant
rhizosphere. These microorganisms have significant potential as
important tools for sustainable agriculture. PGPR enhance the
growth of root systems and often control certain plant pathogens.
As PGPR amelioration is a fascinating subject, is multidisciplinary
in nature, and concerns scientists involved in plant heath and
plant protection, this book is an ideal resource that emphasizes
the current trends of, and probable future of, PGPR developments.
Chapters incorporate both theoretical and practical aspects and may
serve as baseline information for future research. This book will
be useful to students, teachers and researchers, both in
universities and research institutes, especially working in areas
of agricultural microbiology, plant pathology and agronomy.
Cardiovascular Toxicity and Therapeutic Modalities Targeting
Cardio-Oncology: From Basic Research to Advanced Study analyzes the
emerging the field of cardio-oncology, reviewing recent
advancements in the field, discussing how to monitor and treat
cancer survivors for cardiotoxicity, and identifying potential
cardiac side effects in novel cancer therapies. By adopting a
translational approach, the book first comprehensively covers the
basic science, mechanisms and concepts, which is followed by
advanced state-of-art of cardio-oncology. Other sections cover
tyrosine kinase inhibitors, Anthracyclines, and biomarkers in
cardiotoxicity induced by chemotherapeutic drugs, noninvasive
cardiovascular imaging techniques, radiotherapy induced
cardiovascular, and more. Anti-cancer treatment is associated with
serious cardiovascular adverse events, including arterial and
pulmonary hypertension, supraventricular and ventricular
arrhythmias, systolic and diastolic cardiac dysfunction and
coronary artery disease. Progress in cancer therapy over the past
decades improved long-term survival but increased cancer
therapy-related cardiotoxicity. Both traditional chemotherapeutic
agents and newer therapies have demonstrated profound
cardiovascular toxicities. It is important to understand the
mechanisms of these toxicities to establish strategies for the
prevention and management of complications-arrhythmias, heart
failure, and even death.
Joining Processes for Dissimilar and Advanced Materials describes
how to overcome the many challenges involved in the joining of
similar and dissimilar materials resulting from factors including
different thermal coefficients and melting points. Traditional
joining processes are ineffective with many newly developed
materials. The ever-increasing industrial demands for production
efficiency and high-performance materials are also pushing this
technology forward. The resulting emergence of advanced micro- and
nanoscale material joining technologies, have provided many
solutions to these challenges. Drawing on the latest research, this
book describes primary and secondary processes for the joining of
advanced materials such as metals and alloys, intermetallics,
ceramics, glasses, polymers, superalloys, electronic materials and
composites in similar and dissimilar combinations. It also covers
details of joint design, quality assurance, economics and service
life of the product.
This book presents a detailed overview and critical evaluation of
recent advances and remaining challenges in improving nutritional
quality and/or avoiding the accumulation of undesirable substances
in plants using a variety of strategies based on modern biological
tools and techniques. Each review chapter provides an authoritative
and insightful account of the various aspects of nutritional
enhancement of plants. In the course of the last two decades,
several food crops rich in macro- and micronutrients have been
developed to improve health and protect a large section of the
populace in developing countries from chronic diseases. Providing
extensive information on these developments, this book offers a
valuable resource for all researchers, students and industrialists
working in agriculture, the plant sciences, agronomy, horticulture,
biotechnology, food and nutrition, and the soil and environmental
sciences.
Nanotechnology in Modern Animal Biotechnology: Concepts and
Applications discusses the advancement of nanotechnologies in
almost every field, ranging from materials science, to food,
forensic, agriculture and life sciences, including biotechnology
and medicine. Nanotechnology is already being harnessed to address
many of the key problems in animal biotechnology, with future
applications covering animal biotechnology (e.g. animal nutrition,
health, disease diagnosis, and drug delivery). This book provides
the tools, ideas and techniques of nanoscale principles to
investigate, understand and transform biological systems.
Nanotechnology provides the ability to manipulate materials at
atomic and molecular levels and also arrange atom-by-atom on a
scale of ~1-100 nm to create, new materials and devices with
fundamentally new functions and properties arising due to their
small scale.
The book introduces the basic concepts of nanotechnology and the
various technologies to characterize nanomaterials. It also covers
the nanostructural features of mammalian cells/tissues and related
nanomechanical properties. In addition, the book comprehensively
describes the current state-of-the-art and future perspectives of
nanotechnology in biosensors. It also discusses the potential of
nanotechnology for delivering the diverse cancer therapeutics and
illustrates its limitation due to the potential toxicity associated
with oxidative stress. It also highlights the ethical issues and
translational aspects related to nanotechnology. Finally, it
summarizes the applications of nanotechnology in animal
biotechnology, the recent perspectives and future challenges of
nanomedicines. The content of the book are beneficial for the
undergraduate, postgraduate and doctoral students as well the
professionals working in the area of nanotechnology and
nanomedicines.
The main aim of this book is to introduce and give an overview of a
novel, easy, and highly effective heat transfer augmentation
technique for single-phase micro/minichannel heat sink. The
specific objectives of the volume are to: Introduce a novel planar
oblique fin microchannel and cylindrical oblique fin minichannel
heat sink design using passive heat transfer enhancement techniques
Investigate the thermal transport in both planar and cylindrical
oblique fin structures through numerical simulation and systematic
experimental studies. Evaluate the feasibility of employing the
proposed solution in cooling non-uniform heat fluxes and hotspot
suppression Conduct the similarity analysis and parametric study to
obtain empirical correlations to evaluate the total heat transfer
rate of the oblique fin heat sink Investigate the flow mechanism
and optimize the dimensions of cylindrical oblique fin heat sink
Investigate the influence of edge effect on flow and temperature
uniformity in these oblique fin channels.
It seems that when businesses were finally understanding,
implementing, and getting used to industry 4.0, the term 5.0 came
about. Industry 5.0 takes human touch, innovation, and efficiency a
step further in creating a turnaround strategy for corporate
governance. This transformation has brought many questions to the
minds of stakeholders such as when and why this happened. In order
to explore the answers to these questions, further study is
required to understand the prospects and challenges. Opportunities
and Challenges of Business 5.0 in Emerging Markets discusses the
present state and future outlooks of Business 5.0 and aims to
achieve comprehensive insights on the implications of Business 5.0
in the emerging markets. The book also provides insights to
marketers, entrepreneurs, and practitioners to unravel the
opportunities and mitigate the challenges in the competitive world.
Covering key topics such as big data, e-commerce, and value
creation, this reference work is ideal for policymakers, business
owners, managers, industry professionals, researchers, scholars,
practitioners, academicians, instructors, and students.
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