A logic view of 0-1 integer programming problems, providing new insights into the structure of problems that can lead the researcher to more effective solution techniques depending on the problem class. Operations research techniques are integrated into a logic programming environment. The first monographic treatment that begins to unify these two methodological approaches. Logic-based methods for modelling and solving combinatorial problems have recently started to play a significant role in both theory and practice. The application of logic to combinatorial problems has a dual aspect. On one hand, constraint logic programming allows one to declaratively model combinatorial problems over an appropriate constraint domain, the problems then being solved by a corresponding constraint solver. Besides being a high-level declarative interface to the constraint solver, the logic programming language allows one also to implement those subproblems that cannot be naturally expressed with constraints. On the other hand, logic-based methods can be used as a constraint solving technique within a constraint solver for combinatorial problems modelled as 0-1 integer programs.

Neuronal migration is a unique process during the development of brain structure. Although cerebral anomalies resulting from impaired migration have been identified for nearly a century, most of our knowledge has accumulated in the last decade. Disorders of neuronal migration are causes of mental handicap, autism, and epilepsy. Many are genetically determined and need precise diagnosis to provide genetic counselling.

This book addresses the various aspects of neuronal migration disorders in an ordered way. It will help the clinician to acquire insight as well as proficiency in diagnosis. Individual chapters describe subgroups including lissencephalies, subependymal heterotopia, non-lissencephalic cortical dysplasias, anomalies of the corpus callosum, hemimegalencephaly, schizencephaly, polymicrogyria and multisystem disorders with impaired migration such as chromosomal and metabolic syndromes. Neuroradiological and genetic data are provided with the respective chapters.

Although the book is intended for clinical practice, it provides core information for all interested in this important biological process.

A logic view of 0-1 integer programming problems, providing new insights into the structure of problems that can lead the researcher to more effective solution techniques depending on the problem class. Operations research techniques are integrated into a logic programming environment. The first monographic treatment that begins to unify these two methodological approaches. Logic-based methods for modelling and solving combinatorial problems have recently started to play a significant role in both theory and practice. The application of logic to combinatorial problems has a dual aspect. On one hand, constraint logic programming allows one to declaratively model combinatorial problems over an appropriate constraint domain, the problems then being solved by a corresponding constraint solver. Besides being a high-level declarative interface to the constraint solver, the logic programming language allows one also to implement those subproblems that cannot be naturally expressed with constraints. On the other hand, logic-based methods can be used as a constraint solving technique within a constraint solver for combinatorial problems modelled as 0-1 integer programs.

5 Function of Splenic Compartments . . . . . . . . . . . . . . . 45 5. 1 Splenic White Pulp Compartments during Primary T Cell-Dependent Antibody Responses against Protein Antigens . . . . . . . . . . . . . . . . . . . . . . . . . 46 5. 1. 1 Priming of CD4+ Helper T Cells by Dendritic Cells in the PALS . . . . . . . . . . . . . . . . . . . . 46 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 5. 1. 1. 1 5. 1. 2 Interaction of Primed CD4+ T Cells with Antigen-Specific B Cells in the PALS and Formation of Extrafollicular Foci . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 5. 1. 2. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50 5. 1. 3 Formation of Germinal Centres . . . . . . . . . . . . . . . . . . . 50 5. 1. 3. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 5. 1. 4 Localisation of Memory B Cells in the Marginal Zone . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 5. 1. 4. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57 5. 2 Function of the Marginal Zone during Primary Antibody Responses against T Cell-Independent Type 2 Antigens . . . . . . . . 57 5. 2. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59 Function of the Red Pulp . . . . . . . . . . . . . . . . . . . . . . . . . 59 5. 3 5. 3. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 61 5. 4 Role of the Spleen in CD8+ Cytotoxic T Cell Responses . . . . . . . . . . . . . . . 61 5. 4. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 62 The Spleen, Natural Killer Cells 5. 5 and Gamma/Delta T Cells . . . . . . . . . . . . . . . . . . . . . . . . 62 5. 5. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63 6 Recirculation of Lymphocytes Through the Spleen . . 65 6. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67 7 The Role of Cytokines and Chemokines in the Development of Splenic Compartments . . . . . . 69 7. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 72 8 Unsolved Problems of Human Splenic Structure and Function . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73 VI 8. 1 Arterial Blood Supply to the Splenic Follicles and to the Perifollicular Zone. . . . . . . . . . . . . . . . . 73 . . . . 8. 1. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 74 8.

Despite the often-unimaginable horrors of war, bonds of family and friendship can hold us together... Peter Barth was born in Hamburg during the Second World War. Sound and Fury explores war-time memorabilia, tape-recorded conversations, photographs and letters, to uncover amazing stories about his three closest families during the war. All three families lived close by in Hamburg. Towards the end of July 1943, the RAF bombed the city, creating an enormous firestorm and killing 45,000 people. The families survived and were scattered around Europe. His father and cousin were sent to the siege of Leningrad, both returned severely wounded. The Koschel family moved to Krakow. When the Red Army moved west, they had to flee. They came close to being caught in the RAF firestorm of Dresden. Meanwhile the Barths were refugees in a pretty village close to Bergen-Belsen, the horror of which only emerged when it was liberated by the Allies. Just north of there, the Cap Arcona (with Uncle Adam on board) was anchored in the Bay of Lubeck with two other ships, after rescuing thousands of refugees and wounded soldiers. The SS took command and packed the ships with thousands of concentration camp victims. The day before the German forces surrendered, RAF planes bombed and sank them. No one knows why.

Oral Commentary on Mahamudra by His Eminence Garchen Rinpoche given in San Francisco in 1997. Translated by Khenchen Konchog Gyaltshen.