This volume commemorates the 50th anniversary of the appearance in Volume 4 in 1948 of Dr. Jeffries Wyman's famous paper in which he "laid down" the foundations of linkage thermodynamics. Experts in this area contribute articles on the state-of-the-art of this important field and on new developments of the original theory. Among the topics covered in this volume are electrostatic contributions to molecular free energies in solution; site-specific analysis of mutational effects in proteins; allosteric transitions of the acetylcholine receptor; and deciphering the molecular code of hemoglobin allostery.

Praise for the Series:
"The authority, originality, and editing of the review are first class."
--Nature
"The Advances in Protein Chemistry series has been a major factor in the education of protein chemists."
--Journal of the American Chemical Society

Key Features
* Respiratory metabolism in hyperthermophilic organisms
* Structure and stability of hyperstable proteins
* Thermostable DNA polymerases
* DNA stability and DNA binding proteins
* Hyperthermophiles and their heat-shock proteins