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Following 50 years of glucocorticoid use in a clinical setting, an
international body of expert scientists and physicians presents the
most expansive survey of glucocorticoid pharmacology to date. This
work traces the history of glucocorticoid biology from the seminal
description of glucocorticoid insufficiency by Thomas Addison in
the mid-19th century, up to current advances in elucidating the
molecular basis of glucocorticoid action. Important discoveries are
presented, as well as milestones in drug development, a survey of
current clinical practice, and prospects for novel
glucocorticoid-based therapeutics. Scientists and clinicians will
appreciate the scope of this work, which is of special interest to
workers in the fields of endocrinology, inflammation and autoimmune
disease.
This volume forms part of a prestigious series and covers the
latest advances in our understanding of the pathophysiology and
treatment of asthma. Our understanding of asthma has changed
dramatically in recent years, and much of this new information is
brought together in this volume written by inter nationally
recognised authorities. The aim of the book is to review in depth
the changing concepts of inflammatory processes in asthma and to
discuss the implications for research of this common chronic
disease. Many of the advances in and future therapy our
understanding of asthma have originated from a pharmacological
approach, and this volume highlights the promising new options for
pharma cological intervention. It is hoped this book will be
invaluable for research scientists and clinic ians involved in
asthma research and will be a major reference resource for chest
physicians and those involved in the development of novel pharmaceu
tical entities. Each chapter is extensively referenced, generously
illustrated with clear diagrams and photographs, and represents a
state-of-the-art review of this growing area. c.P. PAGE P.l. BARNES
Contents CHAPTER 1 The Pathology of Asthma: An Overview L.A. LAmNEN
and A. LAmNEN. With 10 Figures ...................... 1 A.
Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . .. . . 1 . . . . . . . . . . . . . . . B. Methods to
Investigate the Pathology of Human Asthma ............ 1 C.
Bronchial Epithelium and Inflammatory Cells in Asthmatic Patients
Between Attacks ........................... 2 I. Mast Cells . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . .. . . 4 . . .
. . . . . . . . . . . II. Eosinophils
............................................... 7 III.
Neutrophils.............................................. 10 D.
Bronchial Epithelial Inflammation During an Asthma Attack. . . . .
.. . 10 E. Epithelial Regeneration .... . . . . . . . . . . . . . .
. . . . . . . . .. . . 12 . . . . . . . . ."
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