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A comprehensive reference work: This looseleaf work is an
authoritative compilation of methods for the detection of
autoantibodies (Section A: Methods of Autoantibody Detection); the
structure, function, and molecular and biochemical concepts of
autoantigens (Section B: Autoantigens); and the clinical
significance of measuring autoantibodies in patients with
rheumatic, connective tissue and autoimmune diseases (Section C:
Clinical Significance of Autoantibodies). This unique work brings
together all the molecular and medical information - very difficult
to retrieve otherwise - in ONE publication. The Editors and
contributors are leading experts in the immunological, molecular
biological, and clinical fields. The format of this looseleaf
publication allows regular updating of data as well as inclusion of
new advances in research on autoimmunity. Until now, the work
(Basic work including Supplement 1) included Section A, and the
larger part of Section B, both in an attractive and robust
ringbinder. Audience: By nature and design of this exciting
reference work, it is especially aimed at scientists, including
immunologists, pathologists and molecular biologists, and clinical
chemists, as well as clinicians specializing in rheumatic diseases
and autoimmune disorders, inflammation or clinical immunology.
Supplement 2: This supplement primarily contains Section C
(Clinical Significance of Autoantibodies). As in the other
sections, the contents are presented in a consistently structured
manner, beautifully illustrated with photos and schematic figures.
Extensive literature references are provided. Also, this supplement
includes an addition to Section B (Autoantigens), being chapter
B.1.5: The Antigens Defined by Antikeratin Antibodies (AKA).
Many advances have occurred in the last 5 years especially in
understanding genetic susceptibility factors, the role of immune
response in chronic arthritis and the relationship between cellular
processes that underlie inflammation and tissue damage. All these
are dealt with in depth in the individual contributions. Genetics
studies included illustrate how studies of HLA genes and genes
controlling the autoantibody repertoire may be involved.
Environmental factors are believed to be important and studies both
in humans and in experimental models on the role of viral and
bacterial agents are covered. The fascinating relationship between
microbes, dysregulated immune responses and oncogenes are also
examined. Since autoimmunity is the key aspect of the immunological
response in rheumatoid arthritis, the role of antigens is
re-examined as is the part played by immune T and B cells. New
areas of clinical application of basic science is well presented in
this book, forexample, in examining how markers of cartilage
destruction may become important in monitoring disease activity. A
chapter reviewing possible future novel therapies is included.
Section A: Methods of Autoantibody Detection This Section provides
well structured protocols for autoantibody detection. Step-by-step
procedures are accompanied by explanatory notes and comments, clear
diagrams, line illustrations and excellent photo illustrations.
Extensive literature references lead the way to further background
information. The methods presented were validated by more than 40
leading laboratories active in sera analysis, which indicates that
these methods have been found to be practically useful and lead to
consistent inter-laboratory results: consensus in autoantibody
detection. Section B: Autoantigens This Section contains the first
compilation of full, detailed information on autoantigens related
to important autoimmune diseases. The chapters are all structured
according to an easy-reference fixed template structure: specific
detection methods, cellular localization, biochemical
characteristics, function, cDNA and derived amino acid sequence,
gene structure, B- and T-cell epitopes and lists of published
monoclonal antibodies. The text is greatly enhanced by many
beautiful schematic figures and photo illustrations. As in Section
A, extensive literature references are provided. The information
for this section was brought together by leading experts in their
fields. This Manual is an ideal text and reference book for bench
scientists working in the field of autoimmunity, but also for
rheumatologists, general (internal medicine) physicians or clinical
immunologists caring for patients with autoimmune disorders.
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