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Proteins are exposed to various interfacial stresses during drug
product development. They are subjected to air-liquid,
liquid-solid, and, sometimes, liquid-liquid interfaces throughout
the development cycle-from manufacturing of drug substances to
storage and drug delivery. Unlike small molecule drugs, proteins
are typically unstable at interfaces where, on adsorption, they
often denature and form aggregates, resulting in loss of efficacy
and potential immunogenicity. This book covers both the fundamental
aspects of proteins at interfaces and the quantification of
interfacial behaviors of proteins. Importantly, this book
introduces the industrial aspects of protein instabilities at
interfaces, including the processes that introduce new interfaces,
evaluation of interfacial instabilities, and mitigation strategies.
The audience that this book targets encompasses scientists in the
pharmaceutical and biotech industry, as well as faculty and
students from academia in the surface science, pharmaceutical, and
medicinal chemistry areas.
Proteins are exposed to various interfacial stresses during drug
product development. They are subjected to air-liquid,
liquid-solid, and, sometimes, liquid-liquid interfaces throughout
the development cycle-from manufacturing of drug substances to
storage and drug delivery. Unlike small molecule drugs, proteins
are typically unstable at interfaces where, on adsorption, they
often denature and form aggregates, resulting in loss of efficacy
and potential immunogenicity. This book covers both the fundamental
aspects of proteins at interfaces and the quantification of
interfacial behaviors of proteins. Importantly, this book
introduces the industrial aspects of protein instabilities at
interfaces, including the processes that introduce new interfaces,
evaluation of interfacial instabilities, and mitigation strategies.
The audience that this book targets encompasses scientists in the
pharmaceutical and biotech industry, as well as faculty and
students from academia in the surface science, pharmaceutical, and
medicinal chemistry areas.
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