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Protein Instability at Interfaces During Drug Product Development - Fundamental Understanding, Evaluation, and Mitigation (Paperback, 1st ed. 2021) Loot Price: R2,889
Discovery Miles 28 890
Protein Instability at Interfaces During Drug Product Development - Fundamental Understanding, Evaluation, and Mitigation...

Protein Instability at Interfaces During Drug Product Development - Fundamental Understanding, Evaluation, and Mitigation (Paperback, 1st ed. 2021)

Jinjiang Li, Mary E. Krause, Raymond Tu

Series: AAPS Advances in the Pharmaceutical Sciences Series, 43

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Loot Price R2,889 Discovery Miles 28 890 | Repayment Terms: R271 pm x 12*

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Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity. This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in the surface science, pharmaceutical, and medicinal chemistry areas.

General

Imprint: Springer Nature Switzerland AG
Country of origin: Switzerland
Series: AAPS Advances in the Pharmaceutical Sciences Series, 43
Release date: February 2022
First published: 2021
Editors: Jinjiang Li • Mary E. Krause • Raymond Tu
Dimensions: 235 x 155mm (L x W)
Format: Paperback
Pages: 338
Edition: 1st ed. 2021
ISBN-13: 978-3-03-057179-5
Categories: Books > Medicine > Nursing & ancillary services > Pharmacy / dispensing
Books > Medicine > Other branches of medicine > Pharmacology > General
Books > Science & Mathematics > Chemistry > Physical chemistry > Quantum & theoretical chemistry
Books > Professional & Technical > Biochemical engineering > Biotechnology > General
Books > Professional & Technical > Industrial chemistry & manufacturing technologies > Industrial chemistry > Pharmaceutical technology
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LSN: 3-03-057179-3
Barcode: 9783030571795

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