Integrins: Molecular and Biological Responses to the Extracellular Matrix will help basic, applied, and clinical researchers keep up with the explosion of literature on the integrin family of proteins. This volume extends material previously covered in "Receptors for Extracellular Matrix." It addresses some of the most exciting areas of integrin biology, including the varied roles of integrins in cell division, differentiation, movement, wound healing, inflammation, thrombosis, osteoporosis, and cancer.
Key Features
* Describes key aspects of integrin structure, function, and biology
* Covers collagen receptors, epithelial cell integrins, leukocyte integrins, platelet integrins, integrin signaling, and integrin antagonists
* Investigates the expression and role of integrins during development and in the cytoskeleton
* Includes the actions and influences of integrins in inflammation, thrombosis, and osteoporosis

The chapters in this book thoroughly cover the structure, regulation, and function of matrix metalloproteinases, and provide information on the latest strategies to inhibit enzyme activity. This work will be an indispensable reference tool for investigators with an interest in extracellular matrix biology, matrix turnover, enzymology and biochemistry of proteinases, developmental biology, pathology, and therapeutic interventions.
Key Features
* Provides state-of-the-art information on a field with broad implications to many areas of biology
* Includes detailed coverage of the structure and regulation of all major matrix metalloproteinases
* Chapters focus on a timely and expanding field
* Topics have direct relevance to understanding human disease pathology of cancer, arthritis, and vascular disease
* Discusses latest strategies used in the development of new therapeutics to inhibit metalloproteinase activity