Since Barry Stroud's classic paper in 1968, the general discussion on transcendental arguments tends to focus on examples from theoretical philosophy. It also tends to be pessimistic, or at least extremely reluctant, about the potential of this kind of arguments. Nevertheless, transcendental reasoning continues to play a prominent role in some recent approaches to moral philosophy. Moreover, some authors argue that transcendental arguments may be more promising in moral philosophy than they are in theoretical contexts. Against this background, the current volume focuses on transcendental arguments in practical philosophy. Experts from different countries and branches of philosophy share their views about whether there are actually differences between "theoretical" and "practical" uses of transcendental arguments. They examine and compare different versions of transcendental arguments in moral philosophy, explain their structure, and assess their respective problems and promises. This book offers all those interested in ethics, meta-ethics, or epistemology a more comprehensive understanding of transcendental arguments. It also provides them with new insights into uses of transcendental reasoning in moral philosophy.

Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and metastasize. It also confers motility upon cells through interactions of cell-surface HA with the cytoskeleton. Embryonic cells in the process of movement and proliferation use the same strategy. It is an example of how cancer cells have commandeered normal cellular processes for their own survival and spread. There are also parallels between cancer and wound healing, cancer occasionally being defined as a wound that does not heal.
The growing body of literature regarding this topic has recently progressed from describing the association of hyaluronan and hyaluronidase expression associated with different cancers, to understanding the mechanisms that drive tumor cell activation, proliferation, drug resistance, etc. No one source, however, discusses hyaluronan synthesis and catabolism, as well as the factors that regulate the balance. This book offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer.
* Offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer
* Chapters are written by the leading international authorities on this subject, from laboratories that focus on the investigation of hyaluronan in cancer initiation, progression, and dissemination
* Focuses on understanding the mechanisms that drive tumor cell activation, proliferation, and drug resistance

Robert Stern investigates how scepticism can be countered by using transcendental arguments concerning the necessary conditions for the possibility of experience, language, or thought. He shows that the most damaging sceptical questions concern neither the certainty of our beliefs, nor the reliability of our belief-forming methods, but rather how we can justify our beliefs in the light of our doxastic norms.

Fourteen new essays by a distinguished team of authors offer a broad and stimulating re-examination of transcendental arguments. This is the philosophical method of arguing that what is doubted or denied by the opponent must be the case, as a condition for the possibility of experience, language, or thought. The line-up of contributors features leading figures in the field from both sides of the Atlantic; they discuss the nature of transcendental arguments, and consider their role and value. In particular, they consider how successful such arguments are as a response to sceptical problems. The editor's introduction provides historical context and philosophical orientation for the discussions. This is the first major appraisal of transcendental arguments since the 1970s; they have continued to play a significant role in philosophy, and recent developments in epistemology and metaphysics have raised new questions and challenges for them. Transcendental Arguments will be essential reading for anyone interested in this area of philosophy, and the starting-point for future work.

"Interpreting Hegel means taking a stand on all the philosophical, political and religious problems of our century." Merleau-Ponty
G. W. F. Hegel (1770-1831), arguably the greatest philosopher of the nineteenth century, decisively influenced the direction of all subsequent European thought. He has been interpreted variously as a theist and an atheist, a conservative and a liberal, an essentialist and a proto-existentialist, a rationalist and an irrationalist. In all the areas he covered, Hegel sought a new form of understanding that had eluded his predecessors but which he believed was necessary for mankind to once again find itself "at home in the world."
This collection of works on Hegel reflects the many-sided nature of Hegel's reception from 1831 onwards, and offers critical studies on the full range of his work. The four volumes incorporate the classic readings of Hegel, from both the continental and analytic traditions, and also include the central twentieth-century readings influenced by developments in European thought which reappraise his work. These volumes offer a unique perspective on Hegel by revealing how our understanding of him is influenced by historical readings of his work. Each volume provides a clear and helpful introduction which sets the articles in their historic context and highlights the central philosophical issues they raise.

The great German idealist philosopher G. W. F. Hegel has exerted an immense influence on the development of philosophy from the early 19th century to the present. But the metaphysical aspects of his thought are still under-appreciated. In a series of essays Robert Stern traces the development of a distinctively Hegelian approach to metaphysics and certain central metaphysical issues. The book begins with an introduction that considers this theme as a whole, followed by a section of essays on Hegel himself. Stern then focuses on the way in which certain key metaphysical ideas in Hegel's system, such as his doctrine of the 'concrete universal' and his conception of truth, relate to the thinking of the British Idealists on the one hand, and the American Pragmatists on the other. The volume concludes by examining a critique of Hegel's metaphysical position from the perspective of the 'continental' tradition, and in particular Gilles Deleuze.

This collection of essays by leading international philosophers considers central themes in the ethics of Danish philosopher Knud Ejler Løgstrup (1905–1981). Løgstrup was a Lutheran theologian much influenced by phenomenology and by strong currents in Danish culture, to which he himself made important contributions. The essays in What Is Ethically Demanded? K. E. Løgstrup's Philosophy of Moral Life are divided into four sections. The first section deals predominantly with Løgstrup's relation to Kant and, through Kant, the system of morality in general. The second section focuses on how Løgstrup stands in connection with Kierkegaard, Heidegger, and Levinas. The third section considers issues in the development of Løgstrup's ethics and how it relates to other aspects of his thought. The final section covers certain central themes in Løgstrup's position, particularly his claims about trust and the unfulfillability of the ethical demand. The volume includes a previously untranslated early essay by Løgstrup, "The Anthropology of Kant’s Ethics," which defines some of his basic ethical ideas in opposition to Kant’s. The book will appeal to philosophers and theologians with an interest in ethics and the history of philosophy. Contributors: K. E. Løgstrup, Svend Andersen, David Bugge, Svein Aage Christoffersen, Stephen Darwall, Peter Dews, Paul Faulkner, Hans Fink, Arne Grøn, Alasdair MacIntyre, Wayne Martin, Kees van Kooten Niekerk, George Pattison, Robert Stern, and Patrick Stokes.

This book explores the complex relationship between the philosophical schools of idealism and pragmatism. Idealism is the older tradition, with roots in Plato and Platonism, and has been developed in a myriad of forms. At heart, it holds that reality is either mind-like, or is contained in the mind. Pragmatism is a newer school, traceable to the work of philosophers such as C.S. Peirce and William James in the mid-nineteenth century. It offers a distinctive account of meaning, knowledge, and metaphysics which stresses our place as agents within the world. While these two schools have often been set at odds with one another, it is increasingly recognized that idealism and pragmatism share some important common ground, and that their respective histories have been intertwined. The contributions to this volume, by leading international scholars, put these debates in a new light by studying the interrelation across a range of thinkers and issues, including Kant, Schelling, Hegel, Royce, Renouvier and Collingwood on the one side, and Peirce, James, Dewey and Brandom on the other. This book was first published as a special issue of the British Journal for the History of Philosophy.

This book explores the complex relationship between the philosophical schools of idealism and pragmatism. Idealism is the older tradition, with roots in Plato and Platonism, and has been developed in a myriad of forms. At heart, it holds that reality is either mind-like, or is contained in the mind. Pragmatism is a newer school, traceable to the work of philosophers such as C.S. Peirce and William James in the mid-nineteenth century. It offers a distinctive account of meaning, knowledge, and metaphysics which stresses our place as agents within the world. While these two schools have often been set at odds with one another, it is increasingly recognized that idealism and pragmatism share some important common ground, and that their respective histories have been intertwined. The contributions to this volume, by leading international scholars, put these debates in a new light by studying the interrelation across a range of thinkers and issues, including Kant, Schelling, Hegel, Royce, Renouvier and Collingwood on the one side, and Peirce, James, Dewey and Brandom on the other. This book was first published as a special issue of the British Journal for the History of Philosophy.

Philosophers working within the pragmatist tradition have pictured their relation to Kant and Kantianism in very diverse terms: some have presented their work as an appropriation and development of Kantian ideas, some have argued that pragmatism is an approach in complete opposition to Kant. This collection investigates the relationship between pragmatism, Kant, and current Kantian approaches to transcendental arguments in a detailed and original way. Chapters highlight pragmatist aspects of Kant's thought and trace the influence of Kant on the work of pragmatists and neo-pragmatists, engaging with the work of Peirce, James, Lewis, Sellars, Rorty, and Brandom, among others. They also consider to what extent contemporary approaches to transcendental arguments are compatible with a pragmatist standpoint. The book includes contributions from renowned authors working on Kant, pragmatism and contemporary Kantian approaches to philosophy, and provides an authoritative and original perspective on the relationship between pragmatism and Kantianism.

An original and systematic synthesis of the major postwar developments in theory and policy of balance-of-payments adjustment, this book focuses on the present-day system of pegged-but-adjustable exchange rates and the problems that policy authorities must face if they are to attain full employment, price stability, balance-of-payments equilibrium, and a satisfactory rate of economic growth. The dominate theme of this book is that any system of exchange rates carries with it assumptions about the way it works and how effective the automatic and policy-motivated forces operate to bring about equilibrium in a country's balance of payments. By analyzing balance-of-payments adjustment and policies under alternative exchange-rate systems, and with different assumptions concerning the level of employment and prices, it is possible to embrace a wide variety of contemporary and historical circumstances experienced by individual countries and the world as a whole. In this way the author assesses the economic consequences of the different exchange-rate systems and of the policies that countries may follow to attain their national objectives. In particular it appears to Professor Stern that the international monetary turmoil of the past ten years can be traced to the exchange-rate inflexibilities of the adjustable-peg system and to the creation of excessive reserves under the dollar standard. He demonstrates that the international monetary system must be redesigned to permit greater exchange-rate inflexibility and control over the creation of new international reserve assets.

Philosophers working within the pragmatist tradition have pictured their relation to Kant and Kantianism in very diverse terms: some have presented their work as an appropriation and development of Kantian ideas, some have argued that pragmatism is an approach in complete opposition to Kant. This collection investigates the relationship between pragmatism, Kant, and current Kantian approaches to transcendental arguments in a detailed and original way. Chapters highlight pragmatist aspects of Kant's thought and trace the influence of Kant on the work of pragmatists and neo-pragmatists, engaging with the work of Peirce, James, Lewis, Sellars, Rorty, and Brandom, among others. They also consider to what extent contemporary approaches to transcendental arguments are compatible with a pragmatist standpoint. The book includes contributions from renowned authors working on Kant, pragmatism and contemporary Kantian approaches to philosophy, and provides an authoritative and original perspective on the relationship between pragmatism and Kantianism.

""Hegel's holistic metaphysics challenges much recent ontology with its atomistic and reductionist assumptions; Stern offers us an original reading of Hegel and contrasts him with his predecessor, Kant. ""

This volume explores questions which emerge from considering the relationship between nature and ethics through philosophical, theological, ethical and environmental lenses. It will examine the nature (understood as essence or character) of ethics itself and whether nature (understood as natural world) has embedded in it a moral code, as well as examining how particular ethical/theological worldviews influence our treatment of nature. Is there an abstract, objective moral code in nature? If so, how do we gain access to this code of ethics? Is it only accessible through revelation, as in some religious traditions, or is this code of ethics more generally accessible to humanity? Indeed, does such an objective notion of ethics exist; could it be that ethics are a natural and subjective development? Is ethics a feature of nature, or have we invented it? There is, this volume might suggest, no consensus on these questions, as they at times divide and at times unite both the contributors to this volume and the bodies of scholarly work with which they engage. As time moves forward, investigations into ethics in the context of the relationship between humanity and nature have become more complex, taking account of advances in the natural sciences and a growing appreciation of nature. How are we to understand our relationship with nature, and how does this have implications for our understandings of ethics? Are we now realising the repercussions of our failure to take seriously our experience of climate change? This volume offers the reader a unique and underrepresented interdisciplinary perspective, from philosophers, theologians and environmentalists on the dynamic relationship between nature and ethics. It offers breadth in terms of the range of theoretical, cultural, philosophical and theological frameworks, but balances this with chapters providing an in-depth treatment of particular lenses, e.g. the work of Hegel, or the work of Gordon Kauffman. Through philosophical and theological investigation, these collected essays deepen and problematize the scientific and pragmatic discourses on nature, offering scholars solid resources to engage with some of the most pressing issues of our time in light of ongoing debates at many levels on dealing with climate change.

The Ethical Demand (1956) by K. E. Logstrup is one of the great works of modern moral philosophy: it is presented here in a new translation with introduction and notes. Logstrup puts forward his distinctive view concerning our vulnerability to each other and what this requires of us in response. He starts by considering Jesus's 'proclamation' to love your neighbour and how this can be understood in 'purely human terms' as relating to basic features of our existence. Reflecting on the phenomenon of trust, Logstrup emphasizes the fundamental interdependence of human life and how this gives rise to an 'ethical demand' on us to care for the other, which he characterizes as radical, silent, one-sided, and unfulfillable. In order to make sense of a demand of this sort, Logstrup argues, we must see 'life as a gift', rather than treating ourselves as the sovereign grounds for our own existence. He contrasts this demand to social norms, which are often reciprocal in this way, and argues that while such norms are changeable, the ethical demand itself is absolute. Logstrup therefore makes a fundamental contribution to our understanding of the nature of-and basis for-our obligations to each other. In this critical edition, Logstrup's original text is accurately rendered into readable English and paired with an introduction which explains the main themes and wider context of the work.

An original and systematic synthesis of the major postwar developments in theory and policy of balance-of-payments adjustment, this book focuses on the present-day system of pegged-but-adjustable exchange rates and the problems that policy authorities must face if they are to attain full employment, price stability, balance-of-payments equilibrium, and a satisfactory rate of economic growth. The dominate theme of this book is that any system of exchange rates carries with it assumptions about the way it works and how effective the automatic and policy-motivated forces operate to bring about equilibrium in a country's balance of payments. By analyzing balance-of-payments adjustment and policies under alternative exchange-rate systems, and with different assumptions concerning the level of employment and prices, it is possible to embrace a wide variety of contemporary and historical circumstances experienced by individual countries and the world as a whole. In this way the author assesses the economic consequences of the different exchange-rate systems and of the policies that countries may follow to attain their national objectives. In particular it appears to Professor Stern that the international monetary turmoil of the past ten years can be traced to the exchange-rate inflexibilities of the adjustable-peg system and to the creation of excessive reserves under the dollar standard. He demonstrates that the international monetary system must be redesigned to permit greater exchange-rate inflexibility and control over the creation of new international reserve assets. "Robert M. Stern" is professor emeritus of economics and public policy at the University of Michigan, Ann Arbor. He is the co-director of the Research Seminar in International Economics at the Gerald R. Ford School of Public Policy. He is also head of the Ford School International Concentration and the Ford school program of research on U.S. Japan international economic relations.

Hegel's holistic metaphysics challenges much recent ontology with its atomistic and reductionist assumptions; Stern offers us an original reading of Hegel and contrasts him with his predecessor, Kant. This book should be of interest to advanced students and lecturers in philosophy.

The Phenomenology of Spirit is arguably Hegela (TM)s most influential and important work, and is considered to be essential in understanding Hegela (TM)s philosophical system and his contribution to western philosophy. The Routledge Guidebook to Hegela (TM)s Phenomenology of Spirit introduces the major themes in Hegela (TM)s great book and aids the reader in understanding this key work, examining:

• The context of Hegela (TM)s work and the background to his writing
• Each separate part of the text in relation to its goals, meanings and impact
• The reception the book received when first seen by the world
• The relevance of Hegela (TM)s work to modern philosophy

With a helpful introductory overview of the text, end of chapter summaries and further reading included throughout, this text is essential reading for all students of philosophy, and all those wishing to get to grips with this classic work of philosophy.

[T]he present groundwork is nothing more than the identification and vindication of the supreme principle of morality.' In the Groundwork for the Metaphysics of Morals (1785), Immanuel Kant makes clear his two central intentions: first, to uncover the principle that underpins morality, and secondly to defend its applicability to human beings. The result is one of the most significant texts in the history of ethics, and a masterpiece of Enlightenment thinking. Kant argues that moral law tells us to act only in ways that others could also act, thereby treating them as ends in themselves and not merely as means. Kant contends that despite apparent threats to our freedom from science, and to ethics from our self-interest, we can nonetheless take ourselves to be free rational agents, who as such have a motivation to act on this moral law, and thus the ability to act as moral beings. One of the most studied works of moral philosophy, this new translation by Robert Stern, Joe Saunders, and Christopher Bennett illuminates this famous text for modern readers.

The great German idealist philosopher G. W. F. Hegel has exerted an immense influence on the development of philosophy from the early 19th century to the present. But the metaphysical aspects of his thought are still under-appreciated. In a series of essays Robert Stern traces the development of a distinctively Hegelian approach to metaphysics and certain central metaphysical issues. The book begins with an introduction that considers this theme as a whole, followed by a section of essays on Hegel himself. Stern then focuses on the way in which certain key metaphysical ideas in Hegel's system, such as his doctrine of the 'concrete universal' and his conception of truth, relate to the thinking of the British Idealists on the one hand, and the American Pragmatists on the other. The volume concludes by examining a critique of Hegel's metaphysical position from the perspective of the 'continental' tradition, and in particular Gilles Deleuze.

Robert Stern investigates how scepticism can be countered by using transcendental arguments concerning the necessary conditions for the possibility of experience, language, or thought. He shows that the most damaging sceptical questions concern neither the certainty of our beliefs nor the reliability of our belief-forming methods, but rather how we can justify our beliefs.

A distinguished team of philosophers offer a broad and stimulating examination of the nature, role, and value of transcendental arguments, in interrelated essays specially written for this volume. Transcendental arguments aim to show that what is doubted or denied by the sceptic must be the case, as a condition for the possibility of experience, language, or thought.