Hyaluronan biology is being recognized as an important regulator of
cancer progression. Paradoxically, both hyaluronan (HA) and
hyaluronidases, the enzymes that eliminate HA, have also been
correlated with cancer progression. Hyaluronan, a long-chain
polymer of the extracellular matrix, opens up tissue spaces through
which cancer cells move and metastasize. It also confers motility
upon cells through interactions of cell-surface HA with the
cytoskeleton. Embryonic cells in the process of movement and
proliferation use the same strategy. It is an example of how cancer
cells have commandeered normal cellular processes for their own
survival and spread. There are also parallels between cancer and
wound healing, cancer occasionally being defined as a wound that
does not heal.
The growing body of literature regarding this topic has recently
progressed from describing the association of hyaluronan and
hyaluronidase expression associated with different cancers, to
understanding the mechanisms that drive tumor cell activation,
proliferation, drug resistance, etc. No one source, however,
discusses hyaluronan synthesis and catabolism, as well as the
factors that regulate the balance. This book offers a comprehensive
summary and cutting-edge insight into Hyaluronan biology, the role
of the HA receptors, the hyaluronidase enzymes that degrade HA, as
well as HA synthesis enzymes and their relationship to cancer.
* Offers a comprehensive summary and cutting-edge insight into
Hyaluronan biology, the role of the HA receptors, the hyaluronidase
enzymes that degrade HA, as well as HA synthesis enzymes and their
relationship to cancer
* Chapters are written by the leading international authorities on
this subject, from laboratories that focus on the investigation of
hyaluronan in cancer initiation, progression, and dissemination
* Focuses on understanding the mechanisms that drive tumor cell
activation, proliferation, and drug resistance
General
Is the information for this product incomplete, wrong or inappropriate?
Let us know about it.
Does this product have an incorrect or missing image?
Send us a new image.
Is this product missing categories?
Add more categories.
Review This Product
No reviews yet - be the first to create one!
Welcome to Loot.co.za!
Sign in / Register |Wishlists & Gift Vouchers |Help | Advanced search
