This volume commemorates the 50th anniversary of the appearance in Volume 4 in 1948 of Dr. Jeffries Wyman's famous paper in which he "laid down" the foundations of linkage thermodynamics. Experts in this area contribute articles on the state-of-the-art of this important field and on new developments of the original theory. Among the topics covered in this volume are electrostatic contributions to molecular free energies in solution; site-specific analysis of mutational effects in proteins; allosteric transitions of the acetylcholine receptor; and deciphering the molecular code of hemoglobin allostery.

Praise for the Series:
"The authority, originality, and editing of the review are first class."
--Nature
"The Advances in Protein Chemistry series has been a major factor in the education of protein chemists."
--Journal of the American Chemical Society

Key Features
* Respiratory metabolism in hyperthermophilic organisms
* Structure and stability of hyperstable proteins
* Thermostable DNA polymerases
* DNA stability and DNA binding proteins
* Hyperthermophiles and their heat-shock proteins

From the Reviews of the Previous Volumes
"The authority, originality, and editing of the reviews are first class."
-NATURE
"The Advances in Protein Chemistry series has been a major factor in the education of protein chemists."
-JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The major cause of death in the Western world is some form of vascular disease; and principal among these forms is atherosclerotic heart disease (ASHD). Although much is known about the etiology and treatment of ASHD, there is, as yet, no specific means of prognosis of an impending coronary episode. There are, however, several indications of susceptibility to coronary disease, generally known as risk factors, the foremost of which is hyperlipidemia. Hyperlipidemia is more commonly designated as hypercholesteremia or triglyceridemia, depending upon which moiety is elevated, but since lipids are transported in the blood as members of a lipoprotein complex, the most descriptive general term would be hyperlipoproteinemia. This volume represents an effort to elucidate the origins and metabolic behavior of lipoproteins and their components, to describe aspects of the morphology, biochemistry and experimental induction of ASHD, and to describe modalities of treatment. The contributions to this book include descriptions of cholesterol synthesis and metabolism, as well as the metabolism of bile acids, the principal products of cholesterol metabolism. There are also chapters on the mechanisms of hyperlipidemia and on lipoprotein metabolism. The induction of experimental atherosclerosis and the aortic structural changes caused by this disease are discussed.

Published continuously since 1944, the" Advances in Protein Chemistry and Structural Biology" serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. This eclectic volume features articles on a variety of topical subjects.

Includes new information about protocols and analysis of proteins Eclectic volume presents chapters by a wide range ofleading experts Presents new, cutting-edge information that will serve as an essential addition to any bookshelf or laboratory "

Sudden cardiac arrest is the leading cause of death among adults, yet it need not be fatal. Though survival in most communities is very poor, a few communities achieve rates as high as 50%. Why are some communities so successful in snatching life from the jaws of death? "Resuscitate " describes the steps any EMS system can take to improve cardiac arrest survival. It is written for the medical directors, administrative directors, fire chiefs, dispatch directors, and program supervisor who direct and run EMS systems all across the country, and for the EMTs, paramedics, and dispatchers who provide frontline care.

This second edition of "Resuscitate " provides fifteen concrete steps to improve survival. Four steps will lead to rapid improvements at the local level and are relatively easy to implement. Six additional steps are more difficult to implement but also likely to improve survival. The remaining steps recommend changes at the national level.

"Resuscitate " is the official textbook for the Resuscitation Academy, held twice a year in Seattle. Cosponsored by Seattle Medic One, King County EMS, and the Medic One Foundation, the Academy draws attendees from throughout the world for two intensive days of classes, demonstrations, and workshops to acquire the knowledge and tools to improve survival in their own communities. This new edition includes lessons learned from attendees of the Academy as well as from the faculty's evolving thoughts on how to measure performance and improve survival, one community at a time. It also includes an addendum on the Resuscitation Academy (resuscitationacademy.org).

For more than thirty years, Mickey S. Eisenberg M.D., Ph.D., has played a leading role in developing King County, Washington's emergency response to cases of sudden cardiac arrest, a system recognized as among the very best in the nation. He is a professor of medicine at the University of Washington and serves as the medical director of King County Emergency Medical Services.

"If you care about sudden cardiac arrest in your community and how emergency medical services respond to this critical emergency, I can think of no more important book than this."-from the Foreword by Roger D. White, M.D., Mayo Clinic

"Eisenberg has done a remarkable job in articulating the steps to be taken for communities to improve survival from sudden cardiac arrest. "Resuscitate " is a 'best in class' and one of a kind guide that provides inspiration as well as direction in translating resuscitatioin science into practice. It is essential for all those who seek to establish strategies to improve survival and quality of life for cardiac arrest victims whose hearts are 'too young to die.'" -David B. Hiltz, EMT-P Resuscitation Academy Alumni

"This book was transformative to me and to the EMS system in Durham, North Carolina. I read it cover to cover and attended the Resuscitation Academy. Eisenberg and his colleagues gave me the knowledge, the tools, and the inspiration to improve resuscitation in Durham. Step by step we are getting better and more lives are being saved." -Captain David Jacobs, Durham County Fire Department

Sudden cardiac arrest is the leading cause of death among adults, yet it need not be fatal. Though survival in most communities is very poor, a few communities achieve rates as high as 50%. Why are some communities so successful in snatching life from the jaws of death? Resuscitate! describes the steps any EMS system can take to improve cardiac arrest survival. It is written for the medical directors, administrative directors, fire chiefs, dispatch directors, and program supervisor who direct and run EMS systems all across the country, and for the EMTs, paramedics, and dispatchers who provide frontline care. This second edition of Resuscitate! provides fifteen concrete steps to improve survival. Four steps will lead to rapid improvements at the local level and are relatively easy to implement. Six additional steps are more difficult to implement but also likely to improve survival. The remaining steps recommend changes at the national level. Resuscitate! is the official textbook for the Resuscitation Academy, held twice a year in Seattle. Cosponsored by Seattle Medic One, King County EMS, and the Medic One Foundation, the Academy draws attendees from throughout the world for two intensive days of classes, demonstrations, and workshops to acquire the knowledge and tools to improve survival in their own communities. This new edition includes lessons learned from attendees of the Academy as well as from the faculty's evolving thoughts on how to measure performance and improve survival, one community at a time. It also includes an addendum on the Resuscitation Academy (resuscitationacademy.org). For more than thirty years, Mickey S. Eisenberg M.D., Ph.D. , has played a leading role in developing King County, Washington's emergency response to cases of sudden cardiac arrest, a system recognized as among the very best in the nation. He is a professor of medicine at the University of Washington and serves as the medical director of King County Emergency Medical Services.

Over a decade ago, the field of bioethics was established in response to the increased control over the design of living organisms afforded by both medical genetics and biotechnology. Since its introduction, bioethics has become established as an academic discipline with journals and professional societies, is covered regularly in the media, and affects people everyday around the globe. In response to the increasing need for information about medical genetics and biotechnology as well as the ethical issues these fields raise, Sheed & Ward proudly presents the Readings in Bioethics Series. Edited by Thomas A. Shannon, the series provides anthologies of critical essays and reflections by leading ethicists in four pivotal areas: reproductive technologies, genetic technologies, death and dying, and health care policy. The goal of this series is twofold: first, to provide a set of readers on thematic topics for introductory or survey courses in bioethics or for courses with a particular theme or time limitation. Second, each of the readers in this series is designed to help students focus more thoroughly and effectively on specific topics that flesh out the ethical issues at the core of bioethics. The series is also highly accessible to general readers interested in bioethics. This volume collects critical essays by leading scholars on issues in biotechnology, genetic counseling and the disabled, population screening, race-based gamete selection, stem cell research, reproductive freedom and preimplantation diagnosis, procreation for organ and tissue procurement, and other critical areas where moral and ethical dilemmas are emerging from new and existing practices, policy, and legislation.