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Hypolipidemic Agents (Paperback, Softcover reprint of the original 1st ed. 1975)
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Discovery Miles 28 700
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Hypolipidemic Agents (Paperback, Softcover reprint of the original 1st ed. 1975)
Series: Handbook of Experimental Pharmacology, 41
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The major cause of death in the Western world is some form of
vascular disease; and principal among these forms is
atherosclerotic heart disease (ASHD). Although much is known about
the etiology and treatment of ASHD, there is, as yet, no specific
means of prognosis of an impending coronary episode. There are,
however, several indications of susceptibility to coronary disease,
generally known as risk factors, the foremost of which is
hyperlipidemia. Hyperlipidemia is more commonly designated as
hypercholesteremia or triglyceridemia, depending upon which moiety
is elevated, but since lipids are transported in the blood as
members of a lipoprotein complex, the most descriptive general term
would be hyperlipoproteinemia. This volume represents an effort to
elucidate the origins and metabolic behavior of lipoproteins and
their components, to describe aspects of the morphology,
biochemistry and experimental induction of ASHD, and to describe
modalities of treatment. The contributions to this book include
descriptions of cholesterol synthesis and metabolism, as well as
the metabolism of bile acids, the principal products of cholesterol
metabolism. There are also chapters on the mechanisms of
hyperlipidemia and on lipoprotein metabolism. The induction of
experimental atherosclerosis and the aortic structural changes
caused by this disease are discussed.
General
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