This book initially provides a review of floating drug delivery systems. This system has a bulk density lower than the gastric content. They remain buoyant in the stomach for a prolonged period of time, with the potential for continuous release of drug. Gastric emptying is much more rapid in the fasting state and floating systems really heavily on the presence of food to retard emptying and provide sufficient liquid for effective buoyancy. When microspheres come in contact with gastric fluid the gel formers, polysaccharides, and polymers hydrate to form a colloidal gel barrier that controls the rate of fluid penetration into the device and consequent drug release. The air trapped by the swollen polymer lowers the density and confers buoyancy to the microspheres. However a minimal gastric content needed to allow proper achievement of buoyancy. Hollow microspheres of Acrylic resins 57, Eudragit, PMAA, floating granules are the recent developments in this field. The book then presents studies conducted on producing microspheres containing Antidiabetic drug. The book also discusses various formulation and processing parameters and in-vivo study in wistar rats.

Nanotechnology will serve as multifunctional tools that will not only be used with any number of diagnostic and therapeutic agents, but will change the very foundations of cancer diagnosis, treatment, and prevention. Cancer is a genetically rooted disease that involves the simultaneous occurrence of two general categories of cellular malfunctions. Ligand-mediated targeting of anticancer therapeutics is being explored utilizing he potential of Nanotechnology. The basic principle underlies ligand-targeted therapeutics is that the delivery of antineoplastic drugs to cancer cells- or cancer-associated tissues such as tumor vasculature can be selectively increased by associating the drugs with molecules that bind to antigens or receptors that are either uniquely expressed or over-expressed on the target cells relative to normal tissues. This allows specific delivery of drugs bound with nanoparticles to the cancer cells. This concept is utilized in the study presented in this book. Con-A, a plant lectin is employed here as a ligand which guides the SLN's bearing anticancer drug to the target tumor vasculature. The study summarizes the effective potential of SLN's in suppressing tumor.