High pressure liquid chromatography-frequently called high performance liquid chromatography (HPLC or, LC) is the premier analytical technique in pharmaceutical analysis and is predominantly used in the pharmaceutical industry. Written by selected experts in their respective fields, the Handbook of Pharmaceutical Analysis by HPLC Volume 6, provides a complete yet concise reference guide for utilizing the versatility of HPLC in drug development and quality control. Highlighting novel approaches in HPLC and the latest developments in hyphenated techniques, the book captures the essence of major pharmaceutical applications (assays, stability testing, impurity testing, dissolution testing, cleaning validation, high-throughput screening).

For more than a century, national and international governing bodies have had some involvement in regulating the quality and safety of food during production and delivery. Since the beginnings of this "modern" food regulation in the early 20th century, the way that food is produced, packaged and distributed has changed drastically. It is difficult to determine if technological advances in the areas of polymer science, refrigeration, and transportation have driven the globalization of the food supply or if the food industry has drawn from these technologies to satisfy consumer's desire and need. Ensuring the safety of food requires a complex and ever-changing set of interactions between producers, distributors, consumers and regulators. As advances are made in packaging and food additives, as food distributions systems evolve to meet consumer needs, or as these respond to environmental and population changes, adjustments to regulatory systems may become necessary. Analytical, environmental and materials chemistry can often play important roles in responding to these changes and in continuing to help with the improvement of food safety and security. These five co-editors bring their respective expertise to the subject of the food system and the chemical advancements behind it.

Water is the most crucial material for human survival, after air. Without water, life would not be possible. It is important to know how much water is available to us and how much water is polluted. We need to monitor pollutants vigorously, both at point and nonpoint sources, using advanced analytical techniques that can monitor ultra-trace amounts of contaminants. Water reclamation is an absolute necessity today because we have contaminated our surface water, and even groundwater in some cases, to a point that it is not clean enough for drinking or cooking. Most importantly, water must be used judiciously, and equal treatment must be paid to the reclamation and treatment of contaminated water. This book provides information on various global water challenges and solutions. We face many water challenges in terms of availability, quality, and sustainability (Chapter 1). There is an urgent need to find ways to make water more sustainable. To achieve this objective, we will have to address scientific, technical, economic, and social issues.

Separations of Water Pollutants with Nanotechnology, the latest volume in the Separation Science and Technology series, offers new solutions for remediating water pollution utilizing nanomaterials with separation methods. Current water purification methods are unsuitable, inconvenient or expensive, so there is a need for new and better processes and techniques. Nanomaterials can purify water by removing pollutants such as heavy metals, pathogens, organic compounds, inorganic compounds, pharmaceuticals, and chemicals of emerging concern. These can effectively replace membrane-based methods if the right expertise is developed-this book helps separation scientists do just that. Existing water treatment problems can be solved by applying a nanotechnology-based processes: antimicrobial nanotechnology, zero-valent iron nanoparticles, nanoadsorbents, nano-enhanced membranes, nanometal oxides, and nano photocatalysts. The current literature places emphasis on materials chemistry rather than the separation methods used for water purification. This new volume presents a collection of chapters that deal with remediation based on separation chemistry.

Handbook of Water Purity and Quality, Second Edition provides those involved in water purification research and administration with a comprehensive resource of methods for analyzing water to assure its safety from contaminants, both natural and human caused. The book includes an overview of the subject and discusses major water-related issues in developing and developed countries. Issues covered include sampling for water analysis, regulatory considerations, and forensics in water quality and purity investigations. Microbial as well as chemical contaminations from inorganic compounds, radionuclides, disinfectants, pesticides, and pharmaceuticals, including endocrine disruptors, are discussed at length. In addition, the luxury of municipal water purified for human consumption is unavailable for a very large number of people. To help solve this problem, some economical water purification techniques, including a million-dollar Grainger prizewinner that can save millions of lives have been included. This fully updated second edition includes four new chapters on topics such as the GenX Water Contamination Problem, the impact of climate change on water, and green chemistry solutions to water pollution.

Evaluating Water Quality to Prevent Future Disasters, volume 11 in the Separation Science and Technology series, covers various separation methods that can be used to avoid water catastrophes arising from climate change, arsenic, lead, algal bloom, fracking, microplastics, flooding, glyphosphates, triazines, GenX, and oil contamination. This book provides a valuable resource that will help the reader solve their potential water contamination problems and help them develop their own new approaches to monitor water contamination.

Advances in Water Purification Techniques: Meeting the Needs of Developed and Developing Countries provides a variety of approaches to water purification that can help assist readers with their research and applications. Water contamination problems occur frequently worldwide, hence the most updated knowledge on water purification systems can be helpful in employing the right type of filter or other mechanism of decontamination. The problems with arsenic contamination of water in Bangladesh and the lead problem in Flint, Michigan remind us of the need to monitor water pollution rigorously, from both point and non-point sources.

How will chemists of the future balance competing concerns of environmental stewardship and innovative, cost-effective product development? For chemists to accept the idea that environmental quality and economic prosperity can be intertwined, the concept of the food-energy-water nexus must first be integrated into underlying thought processes. Food, Energy and Water: The Chemistry Connection provides today's scientists with the background information necessary to fully understand the inextricable link between food, energy and water and how this conceptual framework should form the basis for all contemporary research and development in chemistry in particular, and the sciences in general.

Isoelectric focusing (IEF) is a high-resolution, stand-alone technique that can be used as an analytical method or tool for protein purification. The only current book on the market, the Handbook of Isoelectric Focusing and Proteomics is the ideal 'one-stop' source for germane information in this discipline. This highly practical book also contains chapters on alternative methods that may pave the way in the search for efficient techniques for fractionating and purifying proteins. Complete with the history of IEF focusing to authors' insights and practical tips, this book is a must for anyone working in proteomics.
* Is the only current book available on the subject
* Includes author insights and practical tips
* Is an ideal single source for students and researchers working in proteomics

Many hydrological, geochemical, and biological processes associated with water reclamation and reuse are poorly understood. In particular, the occurrence and effects of trace organic and inorganic contaminants commonly found in reclaimed water necessitates careful analysis and treatment prior to safe reuse. "Water Reclamation and Sustainability "is a practical guide to the latest water reclamation, recycling, and reuse theory and practice. From water quality criteria and regulations to advanced techniques and implementation issues, this book offers scientists a toolkit for developing safe and successful reuse strategies. With a focus on specific contaminant removal techniques, this book comprehensively covers the full range of potential inorganic/organic contaminating compounds and highlights proven remediation methods. Socioeconomic implications related to current and future water shortages are also addressed, underscoring the many positive benefits of sustainable water resource management.
Offers pragmatic solutions to global water shortagesProvides an overview of the latest analytical techniques for water monitoringReviews current remediation effortsCovers innovative technologies for green, gray, brown and black water reclamation and reuse

Modern Instrumental Analysis covers the fundamentals of instrumentation and provides a thorough review of the applications of this technique in the laboratory. It will serve as an educational tool as well as a first reference book for the practicing instrumental analyst. The text covers five major sections:
1. Overview, Sampling, Evaluation of Physical Properties, and Thermal Analysis
2. Spectroscopic Methods
3. Chromatographic Methods
4. Electrophoretic and Electrochemical Methods
5. Combination Methods, Unique Detectors, and Problem Solving
Each section has a group of chapters covering important aspects of the titled subject, and each chapter includes applications that illustrate the use of the methods. The chapters also include an appropriate set of review questions.
* Covers the fundamentals of instrumentation as well as key applications
* Each chapter includes review questions that reinforce concepts
* Serves as a quick reference and comprehensive guidebook for practitioners and students alike

High pressure, or high performance, liquid chromatography (HPLC) is the method of choice for checking purity of new drug candidates, monitoring changes during scale up or revision of synthetic procedures, evaluating new formulations, and running control/assurance of the final drug product. HPLC Method Development for Pharmaceuticals provides an extensive overview of modern HPLC method development that addresses these unique concerns. Includes a review and update of the current state of the art and science of HPLC, including theory, modes of HPLC, column chemistry, retention mechanisms, chiral separations, modern instrumentation (including ultrahigh-pressure systems), and sample preparation. Emphasis has been placed on implementation in a pharmaceutical setting and on providing a practical perspective.
HPLC Method Development for Pharmaceuticals is intended to be particularly useful for both novice and experienced HPLC method development chemists in the pharmaceutical industry and for managers who are seeking to update their knowledge.
* Covers the requirements for HPLC in a pharmaceutical setting including strategies for software and hardware validation to allow for use in a regulated laboratory
* Provides an overview of the pharmaceutical development process (clinical phases, chemical and pharmaceutical development activities)
* Discusses how HPLC is used in each phase of pharmaceutical development and how methods are developed to support activities in each phase

After air, water is the most crucial resource for human survival. To achieve water sustainability, we will have to deal with its scarcity and quality, and find ways to reclaim it from various sources. Chemistry and Water: The Science Behind Sustaining the World's Most Crucial Resource applies contemporary and sophisticated separation science and chromatographic methods to address the pressing worldwide concerns of potable water for drinking and safe water for irrigation to raise food for communities around the world. Edited and authored by world-leading analytical chemists, the book presents the latest research and solutions on topics including water quality and pollution, water treatment technologies and practices, watershed management, water quality and food production, challenges to achieving sustainable water supplies, water reclamation techniques, and wastewater reuse.

"Handbook of Modern Pharmaceutical Analysis, Second Edition, " synthesizes the complex research and recent changes in the field, while covering thetechniques and technologyrequired for today's laboratories. The workintegrates strategy, case studies, methodologies, and implications of new regulatory structures, providing complete coverage of quality assurance from the point of discovery to the point of use.
Treats pharmaceutical analysis (PA) as an integral partner to the drug development process rather than as a service to itCovers method development, validation, selection, testing, modeling, and simulation studies combined with advanced exploration of assays, impurity testing, biomolecules, and chiral separations Features detailedcoverage of QA, ethics, and regulatory guidance (quality by design, good manufacturing practice), as well as high-tech methodologies and technologies from"lab-on-a-chip" toLC-MS, LC-NMR, and LC-NMR-MS
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This work provides those involved in water purification research and administration with a comprehensive resource of methods for analyzing water to assure its safety from contaminants, both natural and human caused. The book first provides an overview of major water-related issues in developing and developed countries, followed by a review of issues of sampling for water analysis, regulatory considerations and forensics in water quality and purity investigations. The subsequent chapters cover microbial as well chemical contaminations from inorganic compounds, radionuclides, volatile and semi-volatile compounds, disinfectants, herbicides, and pharmaceuticals, including endocrine disruptors, as well as potential terrorist-related contamination. The last chapter describes the Grainger prize-winning filter that can remove arsenic from water sources and sufficiently protect the health of a large number of people.
- Covers the scope of water contamination problems on a worldwide scale
- Provides a rich source of methods for analyzing water to assure its safety from natural and deliberate contaminants
- Describes thefilter that won the $1million Grainger prize and thereby highlighting an important approach to remediation"

Ion Chromatography: Instrumentation, Techniques and Applications, Volume 13 in the series Separation Science and Technology, provides a modern overview of all aspects of ion chromatography instrumentation and chemistry techniques, including the historical backdrop of some of the key developments. Most existing books on ion chromatography are focused on single column ion chromatography (rarely used today) or applications, or are outdated. This book covers the broad range of technologies in use and explains the advantages of each, helping both experienced and new practitioners to choose the method they need. The editors of this book have all played a key role in the success of ion chromatography at Dionex Corporation, the undisputed leader in ion chromatography for more than 40 years, and are in a unique position to describe both the technology and its applications. Ion chromatography is the technique of choice for analyzing ionic or ionizable compounds in various industries, such as pharmaceuticals and food. In addition, it is very useful for monitoring cationic or anionic impurities in drinking water.

"Monitoring Water Quality" is a practical assessment of one of the most pressing growth and sustainability issues in the developed and developing worlds: water quality. Over the last 10 years, improved laboratory techniques have led to the discovery of microbial and viral contaminants, pharmaceuticals, and endocrine disruptors in our fresh water supplies that were not monitored previously.

This book offers in-depth coverage of water quality issues (natural and human-related), monitoring of contaminants, and remediation of water contamination. In particular, readers will learn about arsenic removal techniques, real-time monitoring, and risk assessment. "Monitoring Water Quality" is a vital text for students and professionals in environmental science, civil engineering, chemistry - anyone concerned with issues of water analysis and sustainability assessment.
Covers in depth the scope of sustainable water problems on a worldwide scaleProvides a rich source of sophisticated methods for analyzing water to assure its safetyDescribes the monitoring of contaminants, including pharmaceutical and endocrine disruptorsHelps to quickly identify the sources and fates of contaminants and sources of pollutants and their loading"