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Confusion now hath made his masterpiece Macbeth II iii 72 Whence
and what are those execrable shape? Paradise Lost Ib 1 681
Confusion worse confounded Paradise Lost Ib 1 995 When the
manuscript for the first part of this book was proposed, it was
anticipated that the discussion of the entire field of protein se
quencing could be covered in a single volume - from purification
and characterization of the protein through fragmentation by
chemical or enzymic means and, finally, to reassembly of the
identified individual peptides into the reconstructed total
sequence. It soon became evident that this would not be possible.
While the intent was to restrict the expose of procedures only to
that information concerned with "hands on" wet chemistry, it became
apparent that a thorough presentation would require, in addition, a
discussion of certain instrumental and more theoretical approaches
not included in the first volume. Furthermore, the entire
understanding of the field of protein sequencing has advanced
appreciably since the inception of this book. The purpose of the
first volume was to provide practical information in sufficient
detail to permit the researcher to undertake the actual sequencing
procedures in his own laboratory."
In the few years since the first edition of this book made its
appearance, under takings in the area of protein sequence
determination have increased at an almost logarithmic pace. The
logic governing such efforts has, predictably, retreated from a
simple sense of curiosity in achieving something that had not
previously been done, to be replaced by an absolute requirement for
sequence information as the best means for understanding heretofore
unattainable aspects of chemical, and structural and functional
mechanistic phenomena. Witness, for example, recent volumes of the
Annual Review of Biochemistry and other review journals, which
treat the genetic control of mitochondrial proteins, mechanisms of
enzyme action, the immunochemistry of collagen, and the role of
lysosomal enzymes in the lipid storage diseases - all on the basis
of known protein sequence information. One must note, too, the
appearance of related works in the area of nucleic acid sequencing.
The technologic advances in chemical sequencing procedures have
proliferated at a remarkable rate. It is in the area of
instrumentation, however, that the greatest advances have taken
place. As a consequence of this, each chapter (with one single
exception) in this book has been extensively revised and updated.
Entire chapters have been replaced in several cases, without
minimizing the value of their original content. In addition, a
second volume will appear soon, dealing with subjects not covered
in the present book."
Three events greatly influenced the course of human history - the
creation of a faith centered on One God, the emergence from the
Dark Ages into a renaissance of enlightenment in the 16th century,
and the religious wars in which almost half the population of
Europe died 100 years later. These shared a common denominator:
that God attended the constant appeals for protection and solace,
in their lives, by royalty and citizens of the time. The
appreciation of this faith was the use of the Name of God, in
Hebrew, considered the language of God, on coins and medals of the
middle ages.
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