There has been growing menace of antibiotic resistance in recent past owing to a number of reasons such as self medication and non-compliance on parts of patients with regard to complete dosage regimen. Medicinal chemists are hard pressed to bring about new molecules to cater to this need. 1,3-pyrimidine derivatives have been explored by a number of scientists worldwide and such these derivatives have emerged potential lead molecules for development of newer antimicrobial moieties. The present work reports the syntheses and evaluation of some 2-(6'-fluorobenzothiazol-2'-ylamino)-4,6-(disubstituted thiouriedo) -1,3-pyrimidine derivatives. Some of the synthesized derivatives showed excellent activity against Gram +ve bacteria Staphyllococcus aureus, Bacillus subtilis, and Gram -ve bacteria Escherichia coli and Pseudomonas aeruginosa. The contents of this book must make an excellent read for those interested in antibiotic research and allied interests.

4-Thiazolidinones are one of the emerging classes of heterocyclic privileged scaffold. Because of their biological importance, several methods have been developed for the synthesis of 4-thiazolidinone skeleton. The only method reported for solid phase synthesis of 4-thiazolidinones is by C. P. Holmes. A careful survey of the literature revealed that solid-phase synthesis of 4-thiazolidinone with a suitable methodology has not been reported yet. The challenge is to develop a solid phase methodology that affords fast and easy generation of combinatorial library of 4-thiazolidinones, with high yield and appropriate diversity. There are three major points for diversification in 4-thiazolidinone scaffold pointed out providing an opportunity to explore different substituent at these positions. Therefore, the present study makes an effort towards the synthesis of a library of 4-thiazolidinones and 4-metathiazanones with suitable diversity at one, two or three points with the use of suitable coupling agents and other reagents.

The present study was undertaken with the objective to explore the anticataract potential of methanolic extract of Butea frondosa leaves by oxidative stress (Hydrogen peroxide) in Goat eyes (lens) and also the anti-inflammatory activity of aqueous extract of Butea frondosa bark in rats. Butea frondosa is commonly known as Palash and the plant belongs to family Leguminosae. In view of the literature findings, sufficient studies were reported on flowers and seeds, and lesser attention was paid towards leaves. Therefore, the present study was planned to concentrate upon leaves and was selected for the study, which is a rich source of phytoconstituents. In Chromatographic studies the TLC plates were observed using different solvent systems, detected under short wave UV spectrophotometer, with a Rf value of 0.26, 0.30, 0.42, 0.55. After conducting phytochemical test, focus was on to isolate the desired compound using repeated column chromatography. Chloroform and Methanol (9:1) were used as eluent for separation of desired compound from the crude extract.