|
Showing 1 - 3 of
3 matches in All Departments
There has been growing menace of antibiotic resistance in recent
past owing to a number of reasons such as self medication and
non-compliance on parts of patients with regard to complete dosage
regimen. Medicinal chemists are hard pressed to bring about new
molecules to cater to this need. 1,3-pyrimidine derivatives have
been explored by a number of scientists worldwide and such these
derivatives have emerged potential lead molecules for development
of newer antimicrobial moieties. The present work reports the
syntheses and evaluation of some
2-(6'-fluorobenzothiazol-2'-ylamino)-4,6-(disubstituted thiouriedo)
-1,3-pyrimidine derivatives. Some of the synthesized derivatives
showed excellent activity against Gram +ve bacteria Staphyllococcus
aureus, Bacillus subtilis, and Gram -ve bacteria Escherichia coli
and Pseudomonas aeruginosa. The contents of this book must make an
excellent read for those interested in antibiotic research and
allied interests.
4-Thiazolidinones are one of the emerging classes of heterocyclic
privileged scaffold. Because of their biological importance,
several methods have been developed for the synthesis of
4-thiazolidinone skeleton. The only method reported for solid phase
synthesis of 4-thiazolidinones is by C. P. Holmes. A careful survey
of the literature revealed that solid-phase synthesis of
4-thiazolidinone with a suitable methodology has not been reported
yet. The challenge is to develop a solid phase methodology that
affords fast and easy generation of combinatorial library of
4-thiazolidinones, with high yield and appropriate diversity. There
are three major points for diversification in 4-thiazolidinone
scaffold pointed out providing an opportunity to explore different
substituent at these positions. Therefore, the present study makes
an effort towards the synthesis of a library of 4-thiazolidinones
and 4-metathiazanones with suitable diversity at one, two or three
points with the use of suitable coupling agents and other reagents.
The present study was undertaken with the objective to explore the
anticataract potential of methanolic extract of Butea frondosa
leaves by oxidative stress (Hydrogen peroxide) in Goat eyes (lens)
and also the anti-inflammatory activity of aqueous extract of Butea
frondosa bark in rats. Butea frondosa is commonly known as Palash
and the plant belongs to family Leguminosae. In view of the
literature findings, sufficient studies were reported on flowers
and seeds, and lesser attention was paid towards leaves. Therefore,
the present study was planned to concentrate upon leaves and was
selected for the study, which is a rich source of
phytoconstituents. In Chromatographic studies the TLC plates were
observed using different solvent systems, detected under short wave
UV spectrophotometer, with a Rf value of 0.26, 0.30, 0.42, 0.55.
After conducting phytochemical test, focus was on to isolate the
desired compound using repeated column chromatography. Chloroform
and Methanol (9:1) were used as eluent for separation of desired
compound from the crude extract.
|
|