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Electroporation gene therapy, or gene electrotransfer, has evolved
greatly over the last few decades as a result of the remarkable
progress in genetic sequencing, gene array analysis, gene cloning,
gene expression detection, DNA manufacture and discovery and
synthesis of siRNA. Electroporation Protocols: Preclinical and
Clinical Gene Medicine, Second Edition provides in-depth knowledge
on the delivery of naked DNA and small-interfering RNA (siRNA) to
the targeted cells, tissues, and animals for prevention and
treatment of disease. It builds on the success of the first edition
and on the progress made in siRNA delivery and DNA vaccines for
large animals as well as discovery of electroporation applications
for the fragile tissues and for internal organs. Written in the
successful Methods in Molecular Biology series format, chapters
include introductions to their respective topics, lists of the
necessary materials and reagents, step-by-step, readily
reproducible protocols and notes on troubleshooting and avoiding
known pitfalls. Authoritative and easily accessible,
Electroporation Protocols: Preclinical and Clinical Gene Medicine,
Second Edition aims to provide not only comprehensive coverage of
the basic theory and practical application of electroporation siRNA
therapy, gene therapy, and vaccine, but also elaborates on the most
current views from the experts in this field, serving as an
invaluable resource for investigators both in and outside of this
field.
Stimulation of the immune system's ability to control and destroy
tumors cont- ues to be the goal of cancer immune therapy; but the
scope has rapidly expanded; approaches are constantly updated; new
molecules are continually introduced; and immune mechanisms are
becoming better understood. This book has no intention of covering
every aspect of immune therapy but rather focuses on the novelty of
cancer immune therapy in an attempt to give readers an opportunity
to absorb the new aspects of immune therapy from a single source.
In this regard, three areas were selected: cytokine immune therapy,
cell-based immune therapy, and targeted immune therapy. In each of
these three sections, only the novel aspects of immune therapy were
described instead of attempting to cover any historical
achievement. In the first section, Cytokine Immune Therapy, the
IL12 family, IL18, IL21, IL24, IL28, and IL29 were emphasized in
regard to the an- tumor function and application in treating
tumors. Most of these selected cyt- ines were discovered in last 10
years. In the second section, Cell-based Immune Therapy, the focus
was engineering potent immune regulatory or effector cells such as
dendritic cells, T cells, and stem cells. Cell engineering design
is primarily based on the increased understanding of the
interaction of tumor antigen-presenting cells, antigen- specific
effector cells, and the tumor microenvironment.
Electroporation gene therapy, or gene electrotransfer, has evolved
greatly over the last few decades as a result of the remarkable
progress in genetic sequencing, gene array analysis, gene cloning,
gene expression detection, DNA manufacture and discovery and
synthesis of siRNA. Electroporation Protocols: Preclinical and
Clinical Gene Medicine, Second Edition provides in-depth knowledge
on the delivery of naked DNA and small-interfering RNA (siRNA) to
the targeted cells, tissues, and animals for prevention and
treatment of disease. It builds on the success of the first edition
and on the progress made in siRNA delivery and DNA vaccines for
large animals as well as discovery of electroporation applications
for the fragile tissues and for internal organs. Written in the
successful Methods in Molecular Biology series format, chapters
include introductions to their respective topics, lists of the
necessary materials and reagents, step-by-step, readily
reproducible protocols and notes on troubleshooting and avoiding
known pitfalls. Authoritative and easily accessible,
Electroporation Protocols: Preclinical and Clinical Gene Medicine,
Second Edition aims to provide not only comprehensive coverage of
the basic theory and practical application of electroporation siRNA
therapy, gene therapy, and vaccine, but also elaborates on the most
current views from the experts in this field, serving as an
invaluable resource for investigators both in and outside of this
field.
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