This book provides readers with an overview of recent theories and methods for studying complex mechanical systems used in energy production, such as wind turbines, but not limited to them. The emphasis is put on strategies for increasing energy efficiency, and on recent industrial applications. Topics cover dynamics and vibration, vibroacoustics, engineering design, modelling and simulation, fault diagnostics, signal processing and prognostics. The book is based on peer-review contributions and invited talks presented at the first International Workshop on MOdelling and Simulation of COmplex Systems for Sustainable Energy Efficiency, MOSCOSSEE 2021, held online on February 25-26, 2021, and organized by the LAboratory of Mechanics, Modelling and Production (LA2MP) from University of Sfax, Tunisia and the Department of Mechanical and Aeronautical engineering, Centre of Asset Integrity Management (C-AIM) from University of Pretoria, South Africa. By offering authoritative information on innovative methods and tools for application in renewable energy production, it provides a valuable resource to both academics and professionals, and a bridge to facilitate communication between the two groups.

This comprehensive volume provides an update on the current state of pharmacometrics in drug development. It consists of nineteen chapters all written by leading scientists from the pharmaceutical industry, regulatory agencies and academia. After an introduction of the basic pharmacokinetic and pharmacodynamic concepts of pharmacometrics in drug development, the book presents numerous examples of specific applications that utilize pharmacometrics with modeling and simulations over a variety of therapeutic areas, including pediatrics, diabetes, obesity, infections, psychiatrics, Alzheimer's disease, and dermatology, among others. The examples illustrate how results from all phases of drug development can be integrated in a more timely and cost-effective process. Applying pharmacometric decision tools during drug development can allow objective, data-based decision making. At the same time, the process can identify redundant or unnecessary experiments as well as some costly clinical trials that can be avoided. In addition to cost saving by expedited development of successful drug candidates, pharmacometrics has an important economic impact in drug product selection. Unsuccessful drug candidates can be identified early and discontinued without expending efforts required for additional studies and allocating limited resources. Hence, pharmacometric modeling and simulation has become a powerful tool to bring new and better medications to the patient at a faster pace and with greater probability of success.

This comprehensive volume provides an update on the current state of pharmacometrics in drug development. It consists of nineteen chapters all written by leading scientists from the pharmaceutical industry, regulatory agencies and academia. After an introduction of the basic pharmacokinetic and pharmacodynamic concepts of pharmacometrics in drug development, the book presents numerous examples of specific applications that utilize pharmacometrics with modeling and simulations over a variety of therapeutic areas, including pediatrics, diabetes, obesity, infections, psychiatrics, Alzheimer's disease, and dermatology, among others. The examples illustrate how results from all phases of drug development can be integrated in a more timely and cost-effective process. Applying pharmacometric decision tools during drug development can allow objective, data-based decision making. At the same time, the process can identify redundant or unnecessary experiments as well as some costly clinical trials that can be avoided. In addition to cost saving by expedited development of successful drug candidates, pharmacometrics has an important economic impact in drug product selection. Unsuccessful drug candidates can be identified early and discontinued without expending efforts required for additional studies and allocating limited resources. Hence, pharmacometric modeling and simulation has become a powerful tool to bring new and better medications to the patient at a faster pace and with greater probability of success.

Updated with the latest clinical advances, Rowland and Tozer’s Clinical Pharmacokinetics and Pharmacodynamics, Fifth Edition, explains the relationship between drug administration and drug response, taking a conceptual approach that emphasizes clinical application rather than science and mathematics. Bringing a real-life perspective to the topic, the book simplifies concepts and gives readers the knowledge they need to better evaluate drug applications. Key updates reflect advances in PK/PD as related to clinical decision-making and drug research and development. An emphasis on the clinical relevance of drugs makes the book especially applicable to pharmacy students preparing for a career in clinical practice. Hundreds of graphs and tables provide visual representations of key pharmacokinetic/pharmacodynamic principles and effects. More than 200 carefully written study questions, with answers and in-depth explanations, help readers enhance their conceptual understanding and learn and retain key information. New and updated examples connect chapter content to real-world settings. Interactive online simulations give students practice using different pharmacokinetic/pharmacodynamic models and parameters. eBook available for purchase. Fast, smart, and convenient, today’s eBooks can transform learning. These interactive, fully searchable tools offer 24/7 access on multiple devices, the ability to highlight and share notes, and more

This book provides readers with an overview of recent theories and methods for studying complex mechanical systems used in energy production, such as wind turbines, but not limited to them. The emphasis is put on strategies for increasing energy efficiency, and on recent industrial applications. Topics cover dynamics and vibration, vibroacoustics, engineering design, modelling and simulation, fault diagnostics, signal processing and prognostics. The book is based on peer-review contributions and invited talks presented at the first International Workshop on MOdelling and Simulation of COmplex Systems for Sustainable Energy Efficiency, MOSCOSSEE 2021, held online on February 25-26, 2021, and organized by the LAboratory of Mechanics, Modelling and Production (LA2MP) from University of Sfax, Tunisia and the Department of Mechanical and Aeronautical engineering, Centre of Asset Integrity Management (C-AIM) from University of Pretoria, South Africa. By offering authoritative information on innovative methods and tools for application in renewable energy production, it provides a valuable resource to both academics and professionals, and a bridge to facilitate communication between the two groups.

How does artistic practice lead to the production of knowledge? How does, in turn, artistic knowledge relate to its material base? How does contingent materiality guide the artist towards finding form and developing a statement? This volume is dedicated to the object as a process in order to offer new insights into the ways the object - broadly construed, comprising digital and other non-classical objects - becomes an active element in artistic practice.

Stephan Schmidt-Tank zeigt, dass sich die Mitgliedschaft in einem supranationalen Index langfristig nicht wertsteigernd auswirkt; er fuhrt dies unter anderem auf die Transparenz Aufnahmeverfahrens fur STOXX-Indizes zuruck. Kulturelle Unterschiede hingegen sind offenbar auf europaischen Kapitalmarkten durchaus von Bedeutung, und es gibt keine Hinweise auf eine homogene, landerubergreifende Investorengruppe.

In welchem Restaurant ist das Essen am leckersten, welche Le-bensmittel schmecken gut, oder welches Automobil hat die beste Qualit t? Die Beantwortung dieser Fragen durch Familienmitglieder oder Bekannte hat einen signifikanten Einfluss auf die Entscheidung des Fragestellenden. 70% der Konsumenten vertrauen den Ratschl gen aus dem pers nlichen Umfeld, der Werbung hingegen schenken nur 59 Prozent ihr Vertrauen. Unternehmen und Marke-tern ist die Bedeutung von Mundpropaganda f r den Umsatz und das Image eines Unternehmens bewusst geworden, deshalb ist Word-of-Mouth sprichw rtlich in aller Munde." Mittlerweile hat sich eine eigene Industrie auf WOM-Marketing spezialisiert, deren Mitglieder sich in der Word-of-Mouth Marketing Association (WOMMA) organisiert haben. Diese Untersuchung analysiert grundlegende Faktoren f r die Erzeugung und Diffusion von WOM, stellt Auswirkungen von Mundpropaganda auf Unternehmen und deren Produkte dar und pr sentiert aktuelle Entwicklungen im WOM-Marketing.

Diplomarbeit aus dem Jahr 2001 im Fachbereich Geowissenschaften / Geographie - Wirtschaftsgeographie, Note: 1,5, Ernst-Moritz-Arndt-Universitat Greifswald (unbekannt, Geographie und Geologie), Sprache: Deutsch, Abstract: Inhaltsangabe: Einleitung: Mit der CO2-Minderungs-Selbstverpflichtung nach der Rio-Folgekonferenz in Kyoto, steigenden Olpreisen und dem Atomausstieg im Hintergrund, ruckt die Nutzung erneuerbarer Energien immer mehr ins Blickfeld. Der Einwand, sie seien zu teuer, soll in der vorliegenden Arbeit untersucht werden. Anhand der Insel Rugen werden regionalwirtschaftliche Folgen von Solarenergie-Nutzung beleuchtet. Schwerpunkt sind Kapitalflusse im Solarinstallations- sowie Image- und Wirtschaftseffekte im Tourismusbereich. Gegenwartig werden auf Rugen jahrlich 2.300 DM/Einwohner fur Energie aufgewendet und fliessen uberwiegend ab. Es wird gezeigt, dass die aktive Sonnenenergienutzung durch Kollektoren (Warme) und Photovoltaikanlagen (Strom) unter heutigen Randbedingungen in Deutschland positive Effekte auf die Regionalentwicklung hat. Dabei sind die zugrunde gelegten Annahmen ausgesprochen vorsichtig und nahezu pessimistisch. Regionale Arbeitsplatze entstehen vor allem im Solarwarmebereich, weil fur die Photovoltaik nur sehr niedrige Ausbauziele zugrundegelegt sind. Die regionale Kapitalbilanz aus abfliessenden Investitionsbetragen und zufliessenden Fordermitteln/vermiedenen Energiekosten ist fur den Kollektoren-Zubau ausgeglichen, fur die Photovoltaiknutzung dagegen klar positiv. Dort verbleibt rund noch einmal soviel wie der investierte Betrag als Kaufkraftsteigerung in der Region. Von besonderem regionalwirtschaftlichem Interesse sind dabei die Stromeinspeisevergutungen des Erneuerbare-Energien-Gesetzes (EEG). Wirtschaftsschwache Regionen konnen davon uberproportional profitieren. Das EEG ist, obgleich thematisch ausgelegt, raumlich wirksam als eine Forderung strukturschwacher/peripherer Raume. Hinzu kommen nicht-monetare Vorteile fur beispielsweis