It began with plutonium, the first element ever manufactured in quantity by humans. Fearing that the Germans would be the first to weaponise the atom, the United States marshalled brilliant minds and seemingly inexhaustible bodies to find a way to create a nuclear chain reaction of inconceivable explosive power. In a matter of months, the Hanford nuclear facility was built to produce the enigmatic and deadly new material that would fuel atomic bombs. In the desert of eastern Washington State, far from prying eyes, scientists Glenn Seaborg, Enrico Fermi and thousands of others-the physicists, engineers, labourers and support staff at the facility-manufactured plutonium for the bomb dropped on Nagasaki, and for the bombs in the current American nuclear arsenal, enabling the construction of weapons with the potential to end human civilisation. With his characteristic blend of scientific clarity and storytelling, Steve Olson asks why Hanford has been largely overlooked in histories of the Manhattan Project and the Cold War. Olson, who grew up just twenty miles from Hanford's B Reactor, recounts how a small Washington town played host to some of the most influential scientists and engineers in American history as they sought to create the substance at the core of the most destructive weapons ever created. The Apocalypse Factory offers a new generation this dramatic story of human achievement and ultimately, of lethal hubris. *2020 marks the 75th anniversary of the United States' detonation of nuclear weapons over the Japanese cities of Hiroshima and Nagasaki on 6 and 9 August 1945.

It began with plutonium, the first element ever manufactured in quantity by humans. Fearing that the Germans would be the first to weaponise the atom, the United States marshalled brilliant minds and seemingly inexhaustible bodies to find a way to create a nuclear chain reaction of inconceivable explosive power. In a matter of months, the Hanford nuclear facility was built to produce the enigmatic and deadly new material that would fuel atomic bombs. In the desert of eastern Washington State, far from prying eyes, scientists Glenn Seaborg, Enrico Fermi and thousands of others-the physicists, engineers, labourers and support staff at the facility-manufactured plutonium for the bomb dropped on Nagasaki, and for the bombs in the current American nuclear arsenal, enabling the construction of weapons with the potential to end human civilisation. With his characteristic blend of scientific clarity and storytelling, Steve Olson asks why Hanford has been largely overlooked in histories of the Manhattan Project and the Cold War. Olson, who grew up just twenty miles from Hanford's B Reactor, recounts how a small Washington town played host to some of the most influential scientists and engineers in American history as they sought to create the substance at the core of the most destructive weapons ever created. The Apocalypse Factory offers a new generation this dramatic story of human achievement and ultimately, of lethal hubris.

Most people know Greg Graffin as the lead singer of the punk band Bad Religion, but few know that he also received a PhD from Cornell University and teaches evolution at the University of California at Los Angeles. In "Anarchy Evolution," Graffin argues that art and science have a deep connection. As an adolescent growing up when "drugs, sex, and trouble could be had on any given night," Graffin discovered that the study of evolution provided a framework through which he could make sense of the world.

In this provocative and personal book, he describes his own coming of age as an artist and the formation of his naturalist worldview on questions involving God, science, and human existence. While the battle between religion and science is often displayed in the starkest of terms, "Anarchy Evolution" provides fresh and nuanced insights into the long-standing debate about atheism and the human condition. It is a book for anyone who has ever wondered if God really exists.

For months in early 1980, scientists, journalists and ordinary people listened anxiously to rumblings in the long quiescent volcano Mount St. Helens. Still, when a massive explosion took the top off the mountain, no one was prepared. Fifty-seven people died and the lives of many others were changed forever. Steve Olson interweaves history, science and vivid personal stories to portray the disaster as a multi-faceted turning point. Powerful economic, political and historical forces influenced who died when the volcano erupted. The eruption of Mount St. Helens transformed volcanic science, the study of environmental resilience and our perceptions of how to survive on an increasingly dangerous planet.

For months in early 1980, scientists, journalists and ordinary people listened anxiously to rumblings in the long quiescent volcano Mount St. Helens. Still, when a massive explosion took the top off the mountain, no one was prepared. Fifty-seven people died and the lives of many others were changed forever. Steve Olson interweaves history, science and vivid personal stories to portray the disaster as a multi-faceted turning point. Powerful economic, political and historical forces influenced who died when the volcano erupted. The eruption of Mount St. Helens transformed volcanic science, the study of environmental resilience and our perceptions of how to survive on an increasingly dangerous planet.

More than 2 million Americans below age 24 self-identify as being of American Indian or Alaska Native descent. Many of the serious behavioral, emotional, and physical health concerns facing young people today are especially prevalent with Native youth (e.g., depression, violence, and substance abuse). Adolescent Native Americans have death rates two to five times the rate of whites in the same age group because of higher levels of suicide and a variety of risky behaviors (e.g., drug and alcohol use, inconsistent school attendance). Violence, including intentional injuries, homicide, and suicide, accounts for three-quarters of deaths for Native American youth ages 12 to 20. Suicide is the second leading cause of death?and 2.5 times the national rate?for Native youth ages 15 to 24. Arrayed against these health problems are vital cultural strengths on which Native Americans can draw. At a workshop held in 2012, by the National Academies of Sciences, Engineering, and Medicine, presenters described many of these strengths, including community traditions and beliefs, social support networks, close-knit families, and individual resilience. In May 2014, the Academies held a follow-up workshop titled Advancing Health Equity for Native American Youth. Participants discussed issues related to (1) the visibility of racial and ethnic disparities in health and health care as a national problem, (2) the development of programs and strategies by and for Native and Indigenous communities to reduce disparities and build resilience, and (3) the emergence of supporting Native expertise and leadership. This report summarizes the presentations and discussions from the workshop. Table of Contents Front Matter 1 Introduction and Themes of the Workshop 2 Voices of Native Youth 3 Contributors to Resilience 4 Health and Well-Being 5 Addressing Health Disparities Through Education 6 Concluding Comments References Appendix A: Workshop Agenda Appendix B: Speaker Biographies Appendix C: Resources

Since 1965 the foreign-born population of the United States has swelled from 9.6 million or 5 percent of the population to 45 million or 14 percent in 2015. Today, about one-quarter of the U.S. population consists of immigrants or the children of immigrants. Given the sizable representation of immigrants in the U.S. population, their health is a major influence on the health of the population as a whole. On average, immigrants are healthier than native-born Americans. Yet, immigrants also are subject to the systematic marginalization and discrimination that often lead to the creation of health disparities. To explore the link between immigration and health disparities, the Roundtable on the Promotion of Health Equity held a workshop in Oakland, California, on November 28, 2017. This summary of that workshop highlights the presentations and discussions of the workshop. Table of Contents Front Matter 1 Introduction 2 The Past and Present of U.S. Immigration Policy 3 Immigration and the Social Determinants of Health 4 The Voices of Immigrants 5 Reflections on the Workshop References Appendix A: Workshop Agenda Appendix B: Speaker Biographical Sketches Appendix C: World Caf Organizations Appendix D: Statement of Task

Even as the U.S. population becomes steadily more diverse, minorities and women remain underrepresented in clinical trials to develop new drugs and medical devices. Although progress in increasing minority participation in clinical trials has occurred, participation rates do not fully represent the overall population of minorities in the United States. This underrepresentation threatens the health of both these populations and the general population, since greater minority representation could reveal factors that affect health in all populations. Federal legislation has sought to increase the representation of minorities and women in clinical trials, but legislation by itself has not been sufficient to overcome the many barriers to greater participation. Only much broader changes will bring about the meaningful participation of all population groups in the clinical research needed to improve health. To examine the barriers to participation in clinical trials and ways of overcoming those barriers, the National Academies of Sciences, Engineering, and Medicine held a workshop in April 2015. This publication summarizes the presentations and discussions from the workshop. Table of Contents Front Matter 1 Introduction and Highlights of the Workshop 2 Historical Perspectives and Context 3 Scientific Issues: Clinically Meaningful Inclusion 4 Recruitment and Retention Issues: Patient, Provider, Institutional, and System Barriers 5 Potential Best Practices and Policy Options References Appendix A: Workshop Agenda Appendix B: Speaker Biographical Sketches Appendix C: Statement of Task

California and other wildfire-prone western states have experienced a substantial increase in the number and intensity of wildfires in recent years. Wildlands and climate experts expect these trends to continue and quite likely to worsen in coming years. Wildfires and other disasters can be particularly devastating for vulnerable communities. Members of these communities tend to experience worse health outcomes from disasters, have fewer resources for responding and rebuilding, and receive less assistance from state, local, and federal agencies. Because burning wood releases particulate matter and other toxicants, the health effects of wildfires extend well beyond burns. In addition, deposition of toxicants in soil and water can result in chronic as well as acute exposures. On June 4-5, 2019, four different entities within the National Academies of Sciences, Engineering, and Medicine held a workshop titled Implications of the California Wildfires for Health, Communities, and Preparedness at the Betty Irene Moore School of Nursing at the University of California, Davis. The workshop explored the population health, environmental health, emergency preparedness, and health equity consequences of increasingly strong and numerous wildfires, particularly in California. This publication is a summary of the presentations and discussion of the workshop. Table of Contents Front Matter 1 Introduction and Overview 2 California Wildfires: Past and Future 3 Populations Impacted by Wildfires 4 Effects of Wildfires on Human Health 5 The Trials of Recovery 6 Enhancing Operational Response 7 The Impact of Mitigation and Preparedness 8 Reflections on the Workshop References Appendix A: Workshop Statement of Task Appendix B: Workshop Agenda Appendix C: Speaker and Planning Committee Biosketches

Suicide prevention initiatives are part of much broader systems connected to activities such as the diagnosis of mental illness, the recognition of clinical risk, improving access to care, and coordinating with a broad range of outside agencies and entities around both prevention and public health efforts. Yet suicide is also an intensely personal issue that continues to be surrounded by stigma. On September 11-12, 2018, the National Academies of Sciences, Engineering, and Medicine held a workshop in Washington, DC, to discuss preventing suicide among people with serious mental illness. The workshop was designed to illustrate and discuss what is known, what is currently being done, and what needs to be done to identify and reduce suicide risk. Improving Care to Prevent Suicide Among People with Serious Mental Illness summarizes presentations and discussions of the workshop. Table of Contents Front Matter 1 Introduction and Overview 2 Patterns of Risk and the Prevention Landscape 3 Suicide Prevention in Health Care Systems 4 Military Service Members and Veterans 5 Native Americans and Alaska Natives 6 Connecting Prevention Along the Continuum of Care 7 Perspectives on the Future Along the Continuum 8 Ideas from the Breakout Sessions 9 Reflections on the Workshop Appendix A: Workshop Agenda Appendix B: Biographical Sketches

Health care is in the midst of a dramatic transformation in the United States. Spurred by technological advances, economic imperatives, and governmental policies, information technologies are rapidly being applied to health care in an effort to improve access, enhance quality, and decrease costs. At the same time, the use of technologies by the consumers of health care is changing how people interact with the health care system and with health information. These changes in health care have the potential both to exacerbate and to diminish the stark disparities in health and well-being that exist among population groups in the United States. If the benefits of technology flow disproportionately to those who already enjoy better coverage, use, and outcomes than disadvantaged groups, heath disparities could increase. But if technologies can be developed and implemented in such a way to improve access and enhance quality for the members of all groups, the ongoing transformation of health care could reduce the gaps among groups while improving health care for all. To explore the potential for further insights into, and opportunities to address, disparities in underserved populations the National Academies of Sciences, Engineering, and Medicine held a workshop in October 2014. The workshop focused on (1) how communities are using digital health technologies to improve health outcomes for racial and ethnic minority populations, (2) how community engagement can improve access to high-quality health information for members of these groups, and (3) on models of successful technology-based strategies to reduce health disparities. This report summarizes the presentations and discussions at the workshop. Table of Contents Front Matter 1 Introduction of the Workshop 2 Technology and Health Disparities 3 Engaging Providers and Racial/Ethnic Minority Patients in Digital Strategies 4 Examples of Engaging Racial/Ethnic Minority Communities in Digital Health Strategies 5 Policy and Technology Perspectives 6 Synthesis of Workshop Messages References Appendix A: Examples of eHealth Solutions Featured at the Workshop Appendix B: Workshop Agenda Appendix C: Speaker Biographical Sketches

Many drug developers have examined new strategies for creating efficiencies in their development processes, including the adoption of genomics-based approaches. Genomic data can identify new drug targets for both common and rare diseases, can predict which patients are likely to respond to a specific treatment, and has the potential to significantly reduce the cost of clinical trials by reducing the number of patients that must be enrolled in order to demonstrate safety and efficacy. A key component of the approval of targeted therapeutics is the ability to identify the population of patients who will benefit from treatment, and this has largely hinged on the co-development and co-submission to the FDA of a companion diagnostic test.The co-development process, or the development of the test and drug for the simultaneous submission to FDA, has led to a major alteration in the way that drugs are being developed, with traditionally separate entities-pharmaceutical and diagnostic companies-now working in close collaboration. Refining Processes for the Co-Development of Genome-Based Therapeutics and Companion Diagnostic Tests is the summary of a workshop held by the Roundtable on Translating Genomic-Based Research for Health on February 27, 2013 to examine and discuss challenges and potential solutions for the codevelopment of targeted therapeutics and companion molecular tests for the prediction of drug response. Prior to the workshop, key stakeholders, including laboratory and medical professional societies, were individually asked to provide possible solutions to resolve the concerns raised about co-development of companion diagnostic tests and therapies. Workshop speakers were charged with addressing these solutions in their presentations by providing insight on (1) whether the proposed solutions address the problems described, (2) whether there are other solutions to propose, and (3) what steps could be taken to effectively implement the proposed solutions. Table of Contents Front Matter 1 Introduction 2 Regulatory Perspectives 3 Perspectives from Patients, Providers, and Laboratory Representatives 4 Perspectives of Diagnostic Test and Pharmaceutical Developers 5 Perspectives of Payers and Regulators 6 Concluding Observations References Appendix A: Workshop Agenda Appendix B: Speaker Biographical Sketches Appendix C: Statement of Task Appendix D: Registered Attendees

The #1 best-seller on franchise development and Amazon #1 best-seller, Grow to Greatness has instantly become the must-read, essential guide on how to build a world-class franchise system faster. This breakthrough book delivers advice and proven, step-by-step systems and processes for emerging and established franchisors, as well as for anyone considering franchising their business. The $29.95 guide has saved existing and potential franchisors thousands of dollars in costly mistakes. -- One hundred+ case examples and checklists reveal how to do it right ... and how not to do it wrong -- Profit from real "best practices" solutions and proven step-by-step processes -- Endorsed by franchising's top brand executives of KFC, Taco Bell, Dunkin' Donuts, Pinkberry, Molly Maids, Postnet, Checkers, AlphaGraphics, Popeye's, Cartridge World, Express Employment Professionals, the International Franchise Association ... and many more. Each benchmark is described in detail, supported by case studies, industry research and steps taken by franchise leaders from various industries. " Steve's Grow to Greatness is the 'Driver's Ed Manual'. It delivers great lessons for startup franchisors and the most seasoned franchise executives. In the words of Bill Rosenberg, founder of Dunkin' Donuts and the International Franchise Association, 'We can avoid failures, if we study success.' Study Grow to Greatness and you will be rewarded." John Reynolds, CFE President, IFA Educational Foundation

The rapid growth of home health care has raised many unsolved issues and will have consequences that are far too broad for any one group to analyze in their entirety. Yet a major influence on the safety, quality, and effectiveness of home health care will be the set of issues encompassed by the field of human factors research-the discipline of applying what is known about human capabilities and limitations to the design of products, processes, systems, and work environments. To address these challenges, the National Research Council began a multidisciplinary study to examine a diverse range of behavioral and human factors issues resulting from the increasing migration of medical devices, technologies, and care practices into the home. Its goal is to lay the groundwork for a thorough integration of human factors research with the design and implementation of home health care devices, technologies, and practices. On October 1 and 2, 2009, a group of human factors and other experts met to consider a diverse range of behavioral and human factors issues associated with the increasing migration of medical devices, technologies, and care practices into the home. This book is a summary of that workshop, representing the culmination of the first phase of the study. Table of Contents Front Matter Part I: Workshop Summary 1 Introduction 2 The People Who Receive and Provide Home Health Care 3 Home Health Care Tasks and Tools 4 The Environments of Home Health Care 5 Concluding Discussion Part II: Workshop Papers 6 The Health Care Challenge: Matching Care to People inTheir Home Environments--Neil Charness 7 Informal Caregivers in the United States: Prevalence, Caregiver Characteristics, and Ability to Provide Care--Richard Schulz and Connie A. Tompkins 8 Medical Devices in Home Health Care--Molly Follette Story 9 Information Technology and Systems in Home Health Care--George Demiris 10 The Physical Environment and Home Health Care--Jonathan Sanford 11 Impact of Cultural, Social, and Community Environments on Home Care--Steven M. Albert 12 Effects of Policy, Reimbursement, and Regulation on Home Health Care--Peter A. Boling Appendix: Workshop Agenda and Participants

In a journey across four continents, acclaimed science writer Steve Olson traces the origins of modern humans and the migrations of our ancestors throughout the world over the past 150,000 years. Like Jared Diamond's Guns, Germs and Steel, Mapping Human History is a groundbreaking synthesis of science and history. Drawing on a wide range of sources, including the latest genetic research, linguistic evidence, and archaeological findings, Olson reveals the surprising unity among modern humans and "demonstrates just how naive some of our ideas about our human ancestry have been" (Discover).Olson offers a genealogy of all humanity, explaining, for instance, why everyone can claim Julius Caesar and Confucius as forebears. Olson also provides startling new perspectives on the invention of agriculture, the peopling of the Americas, the origins of language, the history of the Jews, and more. An engaging and lucid account, Mapping Human History will forever change how we think about ourselves and our relations with others.

The process of discovering and developing a new drug or therapy is extremely costly and time consuming, and recently, it has been estimated that the creation of a new medicine costs on average more than $2 billion and takes 10 years to reach patients. The challenges associated with bringing new medicines to market have led many pharmaceutical companies to seek out innovative methods for streamlining their drug discovery research. One way to increase the odds of success for compounds in the drug development pipeline is to adopt genetically guided strategies for drug discovery, and recognizing the potential benefits of collecting genetic and phenotypic information across specific populations, pharmaceutical companies have started collaborating with healthcare systems and private companies that have curated genetic bioresources, or large databases of genomic information. Large-scale cohort studies offer an effective way to collect and store information that can be used to assess gene?environment interactions, identify new potential drug targets, understand the role of certain genetic variants in the drug response, and further elucidate the underlying mechanisms of disease onset and progression. To examine how genetic bioresources could be used to improve drug discovery and target validation, the National Academies of Sciences, Engineering, and Medicine hosted a workshop in March 2016. Participants at the workshop explored the current landscape of genomics-enabled drug discovery activities in industry, academia, and government; examined enabling partnerships and business models; and considered gaps and best practices for collecting population data for the purpose of improving the drug discovery process. This publication summarizes the presentations and discussions from the workshop. Table of Contents Front Matter 1 Introduction and Themes of the Workshop 2 Maximizing Discovery Capabilities Through Cohort Design 3 Discovery Activities Related to Genetic Bioresources 4 Business Models That Support Bioresource Discovery and Collaboration 5 Potential Next Steps in Using Genomics to Advance Drug Discovery References Appendix A: Workshop Agenda Appendix B: Speaker Biographical Sketches Appendix C: Statement of Task Appendix D: Registered Attendees

Although it is becoming increasingly more common for clinicians to use genomic data in their practices for disease prevention, diagnosis, and treatment, the process of integrating genomic data into the practice of medicine has been a slow and challenging one. Some of the major barriers impeding the incorporation of new genomic technology into clinical practice are: the difficulty of changing routine medical practices to account for the use of genetic testing, the limited knowledge of patients and providers about genomic medicine, assessing sufficient evidence to support the use of genetic tests, privacy and data security issues, and uncertainty about reimbursement. The field of implementation science may be able to provide insights concerning efficient ways to incorporate genomic applications into routine clinical practice. The focus of implementation science studies is to identify integration bottlenecks and optimal approaches for a given setting and ultimately to promote the up-take of research findings. To explore the potential of implementation science to improve the integration of genomics into medicine, the National Academies of Sciences, Engineering, and Medicine held a workshop in Washington, DC, in November 2015. Participants explored the challenges and opportunities of integrating genomic advances into the clinic through the lens of implementation science. This report summarizes the presentations and discussions from the workshop. Table of Contents Front Matter 1 Introduction and Themes of the Workshop 2 Implementation Science: Methods and Approaches 3 Engaging Large and Diverse Populations for Analysis 4 Generating Evidence During Implementation 5 Genomics and Implementation at the Level of Population Health 6 Achieving the Vision References Appendix A: Workshop Agenda Appendix B: Speaker Biographical Sketches Appendix C: Statement of Task Appendix D: Registered Attendees Appendix E: Implementation Science: A Background Appendix F: Large Genetic Cohort Studies: A Background

Environmental monitoring in the Gulf of Mexico poses extensive challenges and significant opportunities. Multiple jurisdictions manage this biogeographically and culturally diverse region, whose monitoring programs tend to be project-specific by design and funding. As a result, these programs form more of a monitoring patchwork then a network. At the same time, the Gulf monitoring community faces a unique opportunity to organize and think differently about monitoring - including how best to allocate and manage the resources for this large marine ecosystem and its communities - as a result of the infusion of resources for environmental restoration and related activities after the Deepwater Horizon oil spill. Opportunities for the Gulf Research Program: Monitoring Ecosystem Restoration and Deep Water Environments summarizes a Gulf Research Program workshop held on September 3-4, 2014 in New Orleans, Louisiana. The workshop gathered about 40 participants from the energy industry, state and federal government, academia, and nongovernmental organizations to examine two broad issues that were seen as time-sensitive opportunities in light of significant investments in the Gulf for restoration and accelerating development of energy resources in the deep Gulf: monitoring ecosystem restoration and deep water environments. As participants explored potential opportunities for the Program to consider, they noted the essential role that communication and outreach play in successful monitoring, and the importance of applying an ecosystem service approach to monitoring, forging partnerships among stakeholders, and supporting efforts to organize and manage monitoring data. Table of Contents Front Matter 1 Introduction 2 Environmental Monitoring: Lessons Learned, Needs and Opportunities in the Gulf of Mexico 3 Monitoring to Support Environmental Restoration 4 Monitoring Needs in the Deep Gulf of Mexico 5 Workshop Synopsis References Appendix A: Workshop Agenda Appendix B: Speaker Biographies Appendix C: Attendees' Roster

Bullying - long tolerated as just a part of growing up - finally has been recognized as a substantial and preventable health problem. Bullying is associated with anxiety, depression, poor school performance, and future delinquent behavior among its targets, and reports regularly surface of youth who have committed suicide at least in part because of intolerable bullying. Bullying also can have harmful effects on children who bully, on bystanders, on school climates, and on society at large. Bullying can occur at all ages, from before elementary school to after high school. It can take the form of physical violence, verbal attacks, social isolation, spreading rumors, or cyberbullying. Increased concern about bullying has led 49 states and the District of Columbia to enact anti-bullying legislation since 1999. In addition, research on the causes, consequences, and prevention of bullying has expanded greatly in recent decades. However, major gaps still exist in the understanding of bullying and of interventions that can prevent or mitigate the effects of bullying. Building Capacity to Reduce Bullying is the summary of a workshop convened by the Board on Children, Youth, and Families of the Institute of Medicine and National Research Council in April 2014 to identify the conceptual models and interventions that have proven effective in decreasing bullying, examine models that could increase protective factors and mitigate the negative effects of bullying, and explore the appropriate roles of different groups in preventing bullying. This report reviews research on bullying prevention and intervention efforts as well as efforts in related areas of research and practice, implemented in a range of contexts and settings, including schools, peers, families, communities, laws and public policies, and technology. Building Capacity to Reduce Bullying considers how involvement or lack of involvement by these sectors influences opportunities for bullying, and appropriate roles for these sectors in preventing bullying. This report highlights current research on bullying prevention, considers what works and what does not work, and derives lessons learned.

The quality of engineering in the United States will only be as good as the quality of the engineers doing it. The recruitment and retention of talented young people into engineering therefore need to be top national priorities, given the crucial importance of engineering to our prosperity, security, health, and well-being. Only 4.4 percent of the undergraduate degrees awarded by US colleges and universities are in engineering, compared with 13 percent in key European countries (the United Kingdom, Sweden, Finland, Denmark, Germany, and France) and 23 percent in key Asian countries (India, Japan, China, Taiwan, South Korea, and Singapore). In the past, the United States has been able to attract engineering graduate students and professionals from other countries to meet the need for engineering talent in the public and private sectors. But other countries are providing increasingly attractive opportunities for engineers, with excellent salaries, facilities, and economic growth potential. The United States can no longer assume that the best engineering talent in the world will want to come to this country. The Importance of Engineering Talent to the Prosperity and Security of the Nation is the summary of a forum held during the National Academy of Engineering's 2013 Annual Meeting. Speakers discussed the opportunities and challenges of creation and wise use of engineering talent, and made recommendations for recruitment and retention strategies. This report assesses the status of engineering education in the U.S. and makes recommendations to promote and improve engineering education. Table of Contents Front Matter I: Talent in the Engineering Enterprise II: From Weaknesses to Strengths in the Search for Engineering Talent Appendix A: Forum Agenda Appendix B: Panelists' Biographies

The development and application of regulatory science - which FDA has defined as the science of developing new tools, standards, and approaches to assess the safety, efficacy, quality, and performance of FDA-regulated products - calls for a well-trained, scientifically engaged, and motivated workforce. FDA faces challenges in retaining regulatory scientists and providing them with opportunities for professional development. In the private sector, advancement of innovative regulatory science in drug development has not always been clearly defined, well coordinated, or connected to the needs of the agency. As a follow-up to a 2010 workshop, the IOM held a workshop on September 20-21, 2011, to provide a format for establishing a specific agenda to implement the vision and principles relating to a regulatory science workforce and disciplinary infrastructure as discussed in the 2010 workshop. Table of Contents Front Matter 1 Introduction 2 The Importance of Innovative Regulatory Science 3 Defining a Discipline of Regulatory Science and Core Competencies for Its Workforce 4 Education and Training of a Regulatory Science Workforce 5 Career Paths Within Academia and Industry 6 International Applications of Regulatory Science 7 Collaborative Models and New Paradigms for Supporting Regulatory Science Research and Practice References Appendix A: Workshop Agenda Appendix B: Participant Biographies

The high rate of incarceration in the United States contributes significantly to the nation's health inequities, extending beyond those who are imprisoned to families, communities, and the entire society. Since the 1970s, there has been a seven-fold increase in incarceration. This increase and the effects of the post-incarceration reentry disproportionately affect low-income families and communities of color. It is critical to examine the criminal justice system through a new lens and explore opportunities for meaningful improvements that will promote health equity in the United States. The National Academies convened a workshop on June 6, 2018 to investigate the connection between incarceration and health inequities to better understand the distributive impact of incarceration on low-income families and communities of color. Topics of discussion focused on the experience of incarceration and reentry, mass incarceration as a public health issue, women's health in jails and prisons, the effects of reentry on the individual and the community, and promising practices and models for reentry. The programs and models that are described in this publication are all Philadelphia-based because Philadelphia has one of the highest rates of incarceration of any major American city. This publication summarizes the presentations and discussions of the workshop. Table of Contents Front Matter 1 Introduction 2 The Experience of Incarceration and Reentry 3 Mass Incarceration as a Public Health Issue 4 Women's Health in Jails and Prisons 5 Reentry: Effects on the Individual and the Community 6 Promising Practices and Models for Reentry 7 The Perspective from the District Attorney's Office 8 Wrap-Up Session Appendix A: References Appendix B: Workshop Agenda Appendix C: Speaker Biographical Sketches Appendix D: Statement of Task

The Chemical Sciences Roundtable (CSR) was established in 1997 by the National Research Council (NRC). It provides a science oriented apolitical forum for leaders in the chemical sciences to discuss chemistry-related issues affecting government, industry, and universities. Organized by the National Research Council's Board on Chemical Sciences and Technology, the CSR aims to strengthen the chemical sciences by fostering communication among the people and organizations - spanning industry, government, universities, and professional associations - involved with the chemical enterprise. One way it does this is by organizing workshops that address issues in chemical science and technology that require national attention. In September 2011, the CSR organized a workshop on the topic, "The Role of Chemical Sciences in Finding Alternatives to Critical Resources." The one-and-a-half-day workshop addressed key topics, including the economic and political matrix, the history of societal responses to key mineral and material shortages, the applications for and properties of existing minerals and materials, and the chemistry of possible replacements. The workshop featured several presentations highlighting the importance of critical nonfuel mineral and material resources in history, catalysis, agriculture, and electronic, magnetic, and optical applications. The Role of the Chemical Sciences in Finding Alternatives to Critical Resources: A Workshop Summary explains the presentations and discussions that took place at the workshop. In accordance with the policies of the NRC, the workshop did not attempt to establish any conclusions or recommendations about needs and future directions, focusing instead on issues identified by the speakers. Table of Contents Front Matter 1 Introduction and Overview 2 Assessments of Criticality 3 Critical Materials in Catalysis 4 Replacing Critical Materials with Abundant Materials 5 Optoelectronics and Photovoltaics 6 Critical Materials in Large-Scale Battery Applications 7 General Observations References A Workshop Agenda B Organizing Committee Biographies C Guest Speaker Biographies D Origin of and Information on the Chemical Sciences Roundtable

From Neurons to Neighborhoods: An Update: Workshop Summary is based on the original study From Neurons to Neighborhoods: Early Childhood Development, which released in October of 2000. From the time of the original publication's release, much has occurred to cause a fundamental reexamination of the nation's response to the needs of young children and families, drawing upon a wealth of scientific knowledge that has emerged in recent decades. The study shaped policy agendas and intervention efforts at national, state, and local levels. It captured a gratifying level of attention in the United States and around the world and has helped to foster a highly dynamic and increasingly visible science of early childhood development. It contributed to a growing public understanding of the foundational importance of the early childhood years and has stimulated a global conversation about the unmet needs of millions of young children. Ten years later, the Board on Children, Youth, and Families of the Institute of Medicine (IOM) and the National Research Council (NRC) held a 2-day workshop in Washington, D.C., to review and commemorate a decade of advances related to the mission of the report. The workshop began with a series of highly interactive breakout sessions in which experts in early childhood development examined the four organizing themes of the original report and identified both measurable progress and remaining challenges. The second day of the workshop, speakers chosen for their diverse perspectives on early childhood research and policy issues discussed how to build on the accomplishments of the past decade and to launch the next era in early childhood science, policy, and practice. From Neurons to Neighborhoods: An Update: Workshop Summary emphasizes that there is a single, integrated science of early childhood development despite the extent to which it is carved up and divided among a diversity of professional disciplines, policy sectors, and service delivery systems. While much work still remains to be done to reach this goal, the 2010 workshop demonstrated both the promise of this integrated science and the rich diversity of contributions to that science. Table of Contents Front Matter 1 *From Neurons to Neighborhoods*: Reflections on Four Themes 2 Research Issues in Early Childhood Development 3 Policy Issues in Early Childhood Development 4 Final Remarks References Appendix A: Original Committee Membership and Charge Appendix B: Workshop Agenda and Participants

Involvement with the juvenile justice system can impact young people's physical and mental health and well-being throughout their lives, as well as the health and well-being of their families and communities. Youth of color are more likely to become involved with the juvenile justice system, and suffer worse outcomes in sentencing, during incarceration, and after release. The National Academies of Sciences, Engineering, and Medicine's Roundtable on the Promotion of Health Equity convened a workshop to discuss the impact that juvenile justice system involvement has on the health and well-being of adolescents, families, and communities of color; examine policies that are successful in improving outcomes; and explore what needs to be done to improve all aspects of encounters with the juvenile justice system. The workshop suggested pursuing alternatives to traditional juvenile justice systems that would allow adolescents to stay in their communities rather than in detention, responding to behavioral problems in youth with interventions that promote health and positive development rather than punishment, and tailoring interventions and programming to participants' cultural background and gender identity. This report summarizes the proceedings of the workshop. Table of Contents Front Matter 1 Introduction and Overview 2 Juvenile Justice and Equitable Outcomes 3 The Effects of Involvement with the Juvenile Justice System 4 Luncheon Panel 5 Alternatives to Juvenile Detention 6 Possible Future Directions 7 Reflections on the Workshop References Appendix A: Statement of Task Appendix B: Workshop Agenda Appendix C: Speaker Biographies