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An integrated reference which could form the basis for advanced
courses on development or become a resource for individuals
teaching basic courses. Following an introduction by the volume
editors, the 11 chapters represent 11 different systems, arranged
phylogenetically, beginning with prokaryotic s
Itisabundantlyclearthattheendocannabinoidsignallingsystemisubiquitously
expressedthroughouttheanimalkingdomfromsimpleinvertebratestoman,and
thatitisrepresentedinalmosteverycelltype.
Thecomponentsofthesysteminrelationtothesynthesisandmetabolismofthe
endocannabinoidsandtheirbiologicaltargetsarebeginningtobeunravelled,but
the degree of complexity involved is enormous. This is particularly
true for
endocannabinoidsignallinginthecentralnervoussystem,whichisthesubjectof
thisvolume.
Inthebook,avarietyofauthors,whoareallveryactiveresearchersinthe?eld,
providecurrentaccountsoftherolesoftheendocannabinoidsysteminnormalbrain
physiologyinrelationtotheneurobiologyofessentialbehaviorsandinanumberof
centraldiseasestates.
The?rstpartprovidesabackgroundand"toolbox",detailingwhatisknown
abouttheendocannabinoidsthemselvesandtheirtargetreceptorsandhowthey
in?uencesynapticactivity.
Itgoesontodescribethegeneticandpharmacological
methodsavailableforinvestigatingthesystem. The second part
describes endocannabinoid roles in key systems controlling
appetite,pain,memoryandlearning,stressresponsesandreproduction.
The?nalgroupofchaptersreviewsthecurrentstateofknowledgesurrounding
thefunctionoftheendocannabinoidsystemindepression,drugaddiction,schi-
phrenia,feedingdisordersandTourette'ssyndrome.
Giventheenormousamountofinformationavailableandtherateofprogressin
research,itisimpossibleforthevolumetobetotallycomprehensive,butwetrust
thatitwillprovideanexcellentbackgroundtoresearcherswantingtoexpandtheir
areaofinterestandtonewcomerstothe?eld. Nottingham,UnitedKingdom
DavidKendall StephenAlexander v Contents PartI
Biochemistry,Pharmacology,GeneticsandChemistry 1
TheLifeCycleoftheEndocannabinoids:Formation andInactivation...3
StephenP. H. AlexanderandDavidA. Kendall 2
EndocannabinoidReceptorPharmacology ...37 KenMackieandBettyYao 3
EndocannabinoidReceptors:CNSLocalizationoftheCB 1
CannabinoidReceptor...65 Istva'nKatona 4
PharmacologicalToolsinEndocannabinoidNeurobiology...87
MarcoMorandAlessioLodola 5 GeneticModelsoftheEndocannabinoidSystem
...111 KrisztinaMonoryandBeatLutz 6
EndocannabinoidSignalinginNeuralPlasticity ...141 BradleyE. Alger 7
LessonsfromNonmammalianSpecies ...173 KenSoderstrom PartII
PhysiologyandPathophysiology 8
RolesoftheEndocannabinoidSysteminLearning andMemory ...201
GiovanniMarsicanoandPaulineLafenetre vii viii Contents 9
EndocannabinoidsandtheNon-HomeostaticControl ofAppetite ...231
TimC. Kirkham 10 Cannabinoid/EndocannabinoidSignalingImpactonEarly
PregnancyEvents...255 XiaofeiSunandSudhansuK. Dey 11
TargetingtheCannabinoidSystemtoProduceAnalgesia ...275
DeviRaniSagar,MaulikJhaveri,andVictoriaChapman 12
IntegrationofEndocannabinoidSignalingintotheNeural
NetworkRegulatingStress-InducedActivationofthe
Hypothalamic-Pituitary-AdrenalAxis ...289 BorisB.
GorzalkaandMatthewN. Hill PartIII Pathology 13 DrugAddiction ...309
ZuzanaJustinova,LeighV. Panlilio,andStevenR. Goldberg 14
RoleofEndocannabinoidSignalinginAnxietyandDepression...347
SachinPatelandCeciliaJ. Hillard 15 FeedingDisordersandObesity...373
CristinaCervino,ValentinaVicennati,RenatoPasquali, andUbertoPagotto
16 Schizophrenia...387 F. Markus 17 Tourette'sSyndrome...397
KirstenR. Mu..ller-Vahl Index ...411 Contributors StephenP. H.
Alexander
SchoolofBiomedicalSciencesandInstituteofNeuroscience,UniversityofN-
tingham Medical School, Queens Medical Centre, Nottingham NG7 2UH,
UK; steve. alexander@nottingham. ac. uk BradleyE. Alger Departments
of Physiology and Psychiatry, University of Maryland School of
Medicine, 655 W. Baltimore St. /BRB 5-025, Baltimore, MD 21201,
USA; balger@umaryland. edu CristinaCervino Endocrinology Unit and
Center of Applied Biomedical Research (C. R. B. A. ),
DepartmentofInternalMedicineandGastroenterology,S.
Orsola-MalpighiHos-
tal,AlmaMaterStudiorumUniversityofBologna,40138Bologna,Italy
VictoriaChapman
SchoolofBiomedicalSciences,UniversityofNottingham,NottinghamNG72UH,
UK;victoria. chapman@nottingham. ac. uk SudhansuK. Dey Departments
of Pharmacology, Pediatrics and Cell & Developmental Biology,
Division of Reproductive and Developmental Biology, Vanderbilt
University MedicalCenter,Nashville,TN37232,USA;sk. dey@vanderbilt.
edu StevenR.
Itisabundantlyclearthattheendocannabinoidsignallingsystemisubiquitously
expressedthroughouttheanimalkingdomfromsimpleinvertebratestoman,and
thatitisrepresentedinalmosteverycelltype.
Thecomponentsofthesysteminrelationtothesynthesisandmetabolismofthe
endocannabinoidsandtheirbiologicaltargetsarebeginningtobeunravelled,but
the degree of complexity involved is enormous. This is particularly
true for
endocannabinoidsignallinginthecentralnervoussystem,whichisthesubjectof
thisvolume.
Inthebook,avarietyofauthors,whoareallveryactiveresearchersinthe?eld,
providecurrentaccountsoftherolesoftheendocannabinoidsysteminnormalbrain
physiologyinrelationtotheneurobiologyofessentialbehaviorsandinanumberof
centraldiseasestates.
The?rstpartprovidesabackgroundand"toolbox",detailingwhatisknown
abouttheendocannabinoidsthemselvesandtheirtargetreceptorsandhowthey
in?uencesynapticactivity.
Itgoesontodescribethegeneticandpharmacological
methodsavailableforinvestigatingthesystem. The second part
describes endocannabinoid roles in key systems controlling
appetite,pain,memoryandlearning,stressresponsesandreproduction.
The?nalgroupofchaptersreviewsthecurrentstateofknowledgesurrounding
thefunctionoftheendocannabinoidsystemindepression,drugaddiction,schi-
phrenia,feedingdisordersandTourette'ssyndrome.
Giventheenormousamountofinformationavailableandtherateofprogressin
research,itisimpossibleforthevolumetobetotallycomprehensive,butwetrust
thatitwillprovideanexcellentbackgroundtoresearcherswantingtoexpandtheir
areaofinterestandtonewcomerstothe?eld. Nottingham,UnitedKingdom
DavidKendall StephenAlexander v Contents PartI
Biochemistry,Pharmacology,GeneticsandChemistry 1
TheLifeCycleoftheEndocannabinoids:Formation andInactivation...3
StephenP. H. AlexanderandDavidA. Kendall 2
EndocannabinoidReceptorPharmacology ...37 KenMackieandBettyYao 3
EndocannabinoidReceptors:CNSLocalizationoftheCB 1
CannabinoidReceptor...65 Istva'nKatona 4
PharmacologicalToolsinEndocannabinoidNeurobiology...87
MarcoMorandAlessioLodola 5 GeneticModelsoftheEndocannabinoidSystem
...111 KrisztinaMonoryandBeatLutz 6
EndocannabinoidSignalinginNeuralPlasticity ...141 BradleyE. Alger 7
LessonsfromNonmammalianSpecies ...173 KenSoderstrom PartII
PhysiologyandPathophysiology 8
RolesoftheEndocannabinoidSysteminLearning andMemory ...201
GiovanniMarsicanoandPaulineLafenetre vii viii Contents 9
EndocannabinoidsandtheNon-HomeostaticControl ofAppetite ...231
TimC. Kirkham 10 Cannabinoid/EndocannabinoidSignalingImpactonEarly
PregnancyEvents...255 XiaofeiSunandSudhansuK. Dey 11
TargetingtheCannabinoidSystemtoProduceAnalgesia ...275
DeviRaniSagar,MaulikJhaveri,andVictoriaChapman 12
IntegrationofEndocannabinoidSignalingintotheNeural
NetworkRegulatingStress-InducedActivationofthe
Hypothalamic-Pituitary-AdrenalAxis ...289 BorisB.
GorzalkaandMatthewN. Hill PartIII Pathology 13 DrugAddiction ...309
ZuzanaJustinova,LeighV. Panlilio,andStevenR. Goldberg 14
RoleofEndocannabinoidSignalinginAnxietyandDepression...347
SachinPatelandCeciliaJ. Hillard 15 FeedingDisordersandObesity...373
CristinaCervino,ValentinaVicennati,RenatoPasquali, andUbertoPagotto
16 Schizophrenia...387 F. Markus 17 Tourette'sSyndrome...397
KirstenR. Mu..ller-Vahl Index ...411 Contributors StephenP. H.
Alexander
SchoolofBiomedicalSciencesandInstituteofNeuroscience,UniversityofN-
tingham Medical School, Queens Medical Centre, Nottingham NG7 2UH,
UK; steve. alexander@nottingham. ac. uk BradleyE. Alger Departments
of Physiology and Psychiatry, University of Maryland School of
Medicine, 655 W. Baltimore St. /BRB 5-025, Baltimore, MD 21201,
USA; balger@umaryland. edu CristinaCervino Endocrinology Unit and
Center of Applied Biomedical Research (C. R. B. A. ),
DepartmentofInternalMedicineandGastroenterology,S.
Orsola-MalpighiHos-
tal,AlmaMaterStudiorumUniversityofBologna,40138Bologna,Italy
VictoriaChapman
SchoolofBiomedicalSciences,UniversityofNottingham,NottinghamNG72UH,
UK;victoria. chapman@nottingham. ac. uk SudhansuK. Dey Departments
of Pharmacology, Pediatrics and Cell & Developmental Biology,
Division of Reproductive and Developmental Biology, Vanderbilt
University MedicalCenter,Nashville,TN37232,USA;sk. dey@vanderbilt.
edu StevenR.
Are your exams coming up? Are you drowning in textbooks and lecture
notes and wondering where to begin? Take the "FASTtrack" route to
successful study for your examinations. "FASTtrack" provides the
ultimate lecture notes and is a must-have for all pharmacy students
wanting to study and test themselves for forthcoming exams.
"FASTtrack: Pharmacology" provides a brief account of drug action,
as either a study or revision aid. In doing this, the authors have
generally taken a therapeutic area and considered the major classes
of drugs, their actions and, to a limited degree, their uses. There
are many excellent brief guides to pharmacology and so their second
aim is to present a study guide which deals with molecular
pharmacology at a more advanced level, so that the book is also
useful for advanced pharmacology studied in the later years of
pharmacy and science degrees. This study guide should therefore be
useful at each level of undergraduate study.New in this edition:
each chapter completely updated to take account of recent changes,
and include future drugs; multiple choice tests; new chapters on
immunopharmacology, oral contraceptives and local anaesthetics;
and, greater use of summary tables.
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Barren Earth
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My Soul's On Fire
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Cannabinoid Pharmacology, Volume 80 is a new volume in the Advances
in Pharmacology that presents reviews of recent breakthroughs. This
volume aims to present current knowledge of the endogenous
cannabinoid system, and looks at molecular, cellular, tissue and
organismal effects of endogenous and exogenous cannabinoids. Topics
of note in this new volume include Endocannabinoids and their
congeners, Endocannabinoid turnover, Plant cannabinoids, Synthetic
cannabinoids and 'legal highs', CB1 and CB2 cannabinoid receptors,
Novel signaling modalities, Novel cannabinoid receptors, and Ion
channel regulation by cannabinoids. There is a broad coverage of
the essential elements associated with the cannabinoid system. The
Editors have sought to include authors who represent authoritative
voices on these themes, but have not previously worked together to
allow a fresh approach to the individual aspects covered.
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