Management of medically compromised patients is an essential part of dental practice. With the present emphasis of patients on esthetics, the branch of orthodontics has no age bounds. An increasing number of patients with complicated medical conditions and drug regimes are seeking orthodontic treatment. Progress in medicine, higher expectations of quality of life, increased life expectancy have resulted in a greater demand for elective dental and medical treatment. This book, therefore, offers a window to manage medically compromised patients in specialized orthodontic practice.

A new, simple, accurate, precise and reproducible UV spectrophotometric method is being developed for the simultaneous estimation of amlodipine besylate, olmesartan medoxomil and hydrochlorthiazide in tablet dosage form. The stock solutions were prepared in methanol. The max for amlodipine besylate, olmesartan medoxomil and hydrochlorthiazide were 238.5nm, 256.5nm and 271.5nm respectively. The amlodipine besylate, olmesartan medoxomil and hydrochlorthiazide obeyed Beer's law in concentration range of 5-25ug/ml, 6-30ug/ml and 5-25ug/ml respectively. Results of analysis of simultaneous equation method were analyzed and validated for various parameters according to ICH guidelines.

Every year many new drugs and newer drug combinations enter the pharmaceutical area. Analytical methods for these new and first timer drugs are mostly confined only to the manufacturing company. However, availability of multiple analytical methods for the same drug/drug combinations in their formulations is always advantageous. Moreover, development of such methods helps in training the analysts for skillfully handling the sophisticated analytical instruments and the way for research approach. The present work is also planned on similar lines. A simple, precise, rapid and accurate Reversed-Phase High Performance Liquid Chromatography method is developed for the simultaneous estimation of Amlodipine Besylate, Olmesartan Medoxomil and Hydrochlorthiazide in dosage forms. Chromatography is carried out isocratically at 25 C 0.5 C on Liquid chromatographic system from Young Lin 9100 comprising of hyperchrome C-18 column (4.6 x 250mm, 5 particle size), manual injector, YL 9110 quaternary pump and Photodiode array YL 9160 detector connected to software YL clarity. Parameters such as linearity, precision, accuracy, recovery and specificity are studied as reported in the ICH guidelines.