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Management of medically compromised patients is an essential part
of dental practice. With the present emphasis of patients on
esthetics, the branch of orthodontics has no age bounds. An
increasing number of patients with complicated medical conditions
and drug regimes are seeking orthodontic treatment. Progress in
medicine, higher expectations of quality of life, increased life
expectancy have resulted in a greater demand for elective dental
and medical treatment. This book, therefore, offers a window to
manage medically compromised patients in specialized orthodontic
practice.
A new, simple, accurate, precise and reproducible UV
spectrophotometric method is being developed for the simultaneous
estimation of amlodipine besylate, olmesartan medoxomil and
hydrochlorthiazide in tablet dosage form. The stock solutions were
prepared in methanol. The max for amlodipine besylate, olmesartan
medoxomil and hydrochlorthiazide were 238.5nm, 256.5nm and 271.5nm
respectively. The amlodipine besylate, olmesartan medoxomil and
hydrochlorthiazide obeyed Beer's law in concentration range of
5-25ug/ml, 6-30ug/ml and 5-25ug/ml respectively. Results of
analysis of simultaneous equation method were analyzed and
validated for various parameters according to ICH guidelines.
Every year many new drugs and newer drug combinations enter the
pharmaceutical area. Analytical methods for these new and first
timer drugs are mostly confined only to the manufacturing company.
However, availability of multiple analytical methods for the same
drug/drug combinations in their formulations is always
advantageous. Moreover, development of such methods helps in
training the analysts for skillfully handling the sophisticated
analytical instruments and the way for research approach. The
present work is also planned on similar lines. A simple, precise,
rapid and accurate Reversed-Phase High Performance Liquid
Chromatography method is developed for the simultaneous estimation
of Amlodipine Besylate, Olmesartan Medoxomil and Hydrochlorthiazide
in dosage forms. Chromatography is carried out isocratically at 25
C 0.5 C on Liquid chromatographic system from Young Lin 9100
comprising of hyperchrome C-18 column (4.6 x 250mm, 5 particle
size), manual injector, YL 9110 quaternary pump and Photodiode
array YL 9160 detector connected to software YL clarity. Parameters
such as linearity, precision, accuracy, recovery and specificity
are studied as reported in the ICH guidelines.
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