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Written by the authors of the renowned embryology textbooks The
Developing Human and Before We Are Born, Concise Clinical
Embryology: An Integrated, Case-Based Approach offers essential,
high-yield information and high-quality clinical cases to
illustrate key principles of embryology and their relevance to
everyday practice. Ideally tailored to the needs of today's medical
students and medical courses, this concise text clearly explains
how embryology relates to other medical disciplines and its
importance in safe, effective clinical practice. Abundant
illustrations throughout help you grasp highly visual concepts
quickly and easily. Provides easily digestible, clinically oriented
coverage of human development, establishing key principles in a
week-by-week, stage-by-stage approach, before moving on to fetal
organ development by body system. Includes clinical cases and
follow-up questions in each chapter that help relate key principles
to everyday practice, aid in problem-based learning, and offer
review for exam preparation. Covers the latest advances in
embryology, including normal and abnormal embryogenesis, causes of
birth defects, and the role of genes in human development. Contains
superb illustrations from cover to cover, including diagnostic
images, full color figures, histology, and more. Summarizes
molecular biology highlights throughout the text. Enhanced eBook
version included with purchase. Your enhanced eBook allows you to
access 18 3D animations with expert commentary, plus all of the
text, figures, and references from the book on a variety of
devices.
Covering the essentials of normal and abnormal human development
for students in a variety of health science disciplines, Before We
Are Born: Essentials of Embryology and Birth Defects, 10th Edition,
reflects new research findings and current clinical practice
through concise text and abundant illustrations. This edition has
been fully updated by the world's foremost embryologists and is
based on the popular text, The Developing Human, written by the
same author team. It provides an easily accessible understanding of
all of the latest advances in embryology, including normal and
abnormal embryogenesis, causes of birth defects, and the role of
genes in human development. Features streamlined content
throughout, numerous photographs of common clinical cases and
embryological explanations, didactic illustrations, and nearly 700
USMLE-style questions with full answers and explanations to help
prepare for professional exams. Includes interactive clinical cases
in every chapter that make important connections between human
development and clinical practice-ideal for preparing for USMLE
Step 1. Features access to 18 full-color, expertly narrated
animations that guide students through key concepts in learning the
complexities of embryologic development. Includes many new color
photographs, new diagnostic images (3D ultrasound, CT scans, and MR
images), an updated teratology section, revised and highlighted
information on molecular aspects of developmental biology, and new
information on the cellular and molecular basis of embryonic
development. Follows the official international list of
embryological terms (Terminologia Embryonica, 2013). Enhanced eBook
version included with purchase. Your enhanced eBook allows you to
access all of the text, figures, and references from the book on a
variety of devices.
Extensively revised to incorporate recent research and current
clinical practice, The Developing Human: Clinically Oriented
Embryology, 11th Edition, covers all aspects of normal and abnormal
embryonic and fetal development. In a clear, concise manner and
lavishly illustrated throughout, this textbook is designed to
successfully meet the needs of medical and health sciences
profession students, as well as those in graduate programs. It
provides an easy-to-digest, comprehensive review of what can be a
complex and challenging subject. BONUS online features such as
multiple-choice questions and narrated animations further support
student success. Guides readers month by month and stage by stage
through embryo and fetal organ and systems development, using
full-color photographs of clinical cases, relevant modern medical
imaging, and numerous high-quality supportive figures. Includes
many new 3D HD color rendered images of embryos and fetuses, as
well as 3D reconstructions of whole embryos. Provides
clinically-oriented problems for each chapter, with corresponding
answers and explanations designed to facilitate discussion and
learning. In addition, multiple-choice questions and answers are
available online for supportive self-assessment. Features 18
exceptional color animations, now with narration, to help students
as they explore and learn the complexity of embryological
development. Provides the knowledge base needed for today's
examinations, including USMLE Step 1, as well as for future
clinical practice. Thoroughly updated information includes new
annotations on fundamental molecular events during embryogenesis,
now required for many professional examinations. Includes enhanced
clinical material in all chapters, with updated tables, Clinical
Case highlights and a critical chapter on common signalling
pathways during development that covers gene editing (CRISPR/Cas9),
induced pluripotent stem cells (iPS), a revision of the sonic
hedgehog signalling pathway; and more. Details how molecular
biology has affected clinical practice, including techniques such
as recumbent DNA technology and stem cell manipulation. Includes an
Enhanced eBook version with purchase. Your enhanced eBook allows
you to access all of the text, figures, and references from the
book on a variety of devices.
Birth defects have assumed an importance even greater now than in
the past because infant mortality rates attributed to congenital
anomalies have declined far less than those for other causes of
death, such as infectious and nutritional diseases. As many as 50 %
of all pregnancies terminate as miscarriages, and in the majority
of cases this is the result of faulty intrauterine development.
Major congenital malformations are present in at least 2 % of all
liveborn infants, and 22 % of all sti1Ibirths and infant deaths are
associated with severe congenital anomalies. Not surprisingly,
there has been a great proliferation of research into the problems
of developmental abnormalities over the past few decades. This
series, Advances in the Study of Birth Defects, was conceived in
order to provide a comprehensive focal source of up-to-date
information for physi cians concerned with the health of the unborn
child and for research workers in the fields of fetal medicine and
birth defects. The first four volumes featured recent experimental
work on selected areas of high priority and intensive
investigation, including mechanisms of teratogenesis, teratological
evaluation, molecular and cellular aspects of abnormal development,
and neural and behavioural teratology. It seems logical and timely
that the clinical aspects should now be presented. Accordingly,
leading experts were invited to review a broad range of common
problems from the standpoint of embryology, aetiology, clinical
manifestations, diagnosis and management. This volume deals with
cardiovascular, respiratory, gastrointestinal, and genitourinary
malformations."
The study of birth defects has assumed an importance even greater
now than in the past because mortality rates attributed to
congenital anomalies have declined far less than those for other
causes of death, such as infectious and nutritional diseases. It is
estimated that as many as 50% of all pregnancies terminate as
miscarriages. In the majority of cases this is the result of faulty
development. Major congenital malformations are found in at least
2% of all liveborn infants, and 22% of all stillbirths and infant
deaths are associated with severe congenital anomalies.
Teratological studies of an experimental nature are neither ethical
nor justifiable in humans. Numerous investigations have been
carried out in laboratory animals and other experimental models in
order to improve our understanding of abnormal intra-uterine
development. In less than two decades the field of experimental
teratology has advanced phenomenally. As a result of the wide range
of information that is now accumulating, it has become possible to
obtain an insight into the causes, mechanisms and prevention of
birth defects. However, considerable work will be needed before
these problems can be resolved. This book brings together some of
the more recent and important research findings related to the
mechanisms and pathogenesis of abnormal develop ment. It is not
only a documentation of the latest experimental work, but it also
points out future directions that seem productive and challenging."
Birth defects have assumed an importance even greater now than in
the past because infant mortality rates attributed to congenital
anomalies have declined far less than those for other causes of
death, such as infectious and nutritional diseases. As many as 50 %
of all pregnancies terminate as miscarriages, and in the majority
of cases this is the result of faulty intrauterine development.
Major congenital malformations are present in at least 2 % of all
liveborn infants, and 22 % of all stillbirths and infant deaths are
associated with severe congenital anomalies. Not surprisingly,
there has been a great proliferation of research into the problems
of developmental abnormalities over the past few decades. This
series, Advances in the Study of Birth Defects, was conceived in
order to provide a comprehensive focal source of up-to-date
information for physi cians concerned with the health of the unborn
child and for research workers in the fields of fetal medicine and
birth defects. The first four volumes featured recent experimental
work on selected areas of high priority and intensive
investigation, including mechanisms of teratogenesis, teratological
evaluation, molecular and cellular aspects of abnormal development,
and neural and behavioural teratology. It seems logical and timely
that the clinical aspects should now be presented. Accordingly,
leading experts were invited to review a broad range of common
problems from the standpoint of embryology, aetiology, clinical
manifestations, diagnosis and management. This volume deals with
genetic disorders and prenatal diagnosis."
The study of birth defects has assumed an importance even greater
now than in the past because mortality rates attributed to
congenital anomalies have declined far less than those for other
causes of death, such as infectious and nutritional diseases. It is
estimated that as many as 50% of all pregnancies terminate as
miscarriages. In the majority of cases this is the result of faulty
development. Major congenital malformations are found in at least
2% of all liveborn infants, and 22% of all stillbirths and infant
deaths are associated with severe congenital anomalies.
Teratological studies of an experimental nature are neither ethical
nor justifiable in humans. Numerous investigations have been
carried out in laboratory animals and other experimental models in
order to improve our understanding of abnormal intra-uterine
development. In less than two decades the field of experimental
teratology has advanced phenomenally. As a result of the wide range
of information that is now accumulating, it has become possible to
obtain an insight into the causes, mec.;hanisms and prevention of
birth defects. However, considerable work will be needed before
these problems can be resolved. The. contributions in this volume
deal primarily with the areas of terato logical evaluation and the
use of selected animal models for the study of con genital
anomalies. It is not only a documentation of the latest
experimental work, but it also indicates new and important areas
for future research."
The study of birth defects has assumed an importance even greater
now than in the past because mortality rates attributed to
congenital anomalies have declined far less than those for other
causes of death, such as infectious and nutritional diseases. It is
estimated that as many as 50% of all pregnancies terminate as
miscarriages. In the majority of cases this is the result of faulty
development. Major congenital malformations are found in at least
2% of all liveborn infants, and 22% of all stillbirths and infant
deaths are associated with severe congenital anomalies.
Teratological studies of an experimental nature are neither ethical
nor justifiable in humans. Numerous investigations have been
carried out in laboratory animals and other experimental models in
order to improve our understanding of abnormal intrauterine
development. In less than two decades the field of experimental
teratology has advanced phenomenally. As a result of the wide range
of information that is now accumulating, it has become possible to
obtain an insight into the causes, mechanisms, and prevention of
birth defects. However, considerable work will be needed before
these problems can be resolved. The comributions in this volume
include some of the more recent and exciting observations on the
cellular and molecular aspects of developmental defects. It is not
only a documentation of the latest experimental work, but it also
indicates new and important areas for future research.
Surprisingly, the beginning of a modern approach This collection of
articles and commentaries is an to the problems of birth defects is
relatively recent integration of information from many disciplines,
and dates from Gregg's classical report in 1941 that and presents a
comprehensive survey of both recent mothers who contracted rubella
during the first tri and previously reported work related to the
major mester of pregnancy gave birth to infants with severe aspects
of birth defects. In particular, an attempt multiple anomalies. For
the first time, an environ has been made to provide a critical
assessment of mental agent was found to be teratogenic in man
current concepts and to identify areas in need of and was
documented in a thoroughly convincing further investigation.
manner. Since then, many important discoveries The scope of this
volume and space limitations and significant developments have been
made, par precluded discussion of and reference to all papers
ticularly in the areas of environmental teratogenesis, of relevance
or importance: a work of the present hereditary mechanisms, and
prenatal diagnosis. nature must necessarily be selective. Some good
In recent years, there has been an impressive papers have been left
out or given relatively little surge of interest in the causes and
prevention of consideration. It is my hope that the list of Further
birth defects. Undoubtedly this resulted not only References will
be consulted and should compensate from the thalidomide tragedy,
but also from the for this lack of completeness."
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