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The purpose of the present work was to design & evaluate
sustained release tablets of Nifedipine, employing hydrophilic
polymer to improve dissolution rates of the drug. METHOCEL K15MCR
& METHOCEL K100LVCR were used in tablets prepared by direct
compression. The formulated tablets were physicochemically
characterized & results were found in acceptable limits. Poor
aqueous solubility of Nifedipine leads to variable dissolution
rates. The main effect & interaction terms were quantitatively
evaluated using mathematical models. Dissolution data were fitted
to zero order, first order, Higuchi's, Korsmeyer-Peppas &
Hixson-Crowell release kinetics to evaluate kinetic data. The drug
release data fit well to the Higuchi expression, but a close
relationship was also noted with zero order kinetics. Korsmeyer's
plot indicated that the drug release mechanism from the matrix
tablet was to be found Fickian mechanism. Regulated drug release
study indicate that the matrix tablets of Nifedipine prepared using
above polymers can successfully be employed as twice-a-day oral
controlled release dosage form.
The purpose of the present investigation was to design and evaluate
sustained release tablets of a sparingly water soluble drug
Ambroxol Hydrochloride, two hydrophilic polymers METHOCEL K15MCR
and METHOCEL K100MCR and hydrophobic Eudragit RL100 were used in
tablets prepared by direct compression. The granules were evaluated
for angle of repose, loose bulk density, tapped bulk density,
compressibility index, total porosity and drug content. The tablets
were subjected to various tests for physical parameters such as
thickness, hardness and friability, and in vitro release studies.
The in vitro dissolution study was carried out for 12 hours using
United States Pharmacopoeia (USP) paddle-type dissolution apparatus
(Apparatus 2) in phosphate buffer (pH 6.8). The results of
dissolution studies indicated that formulations containing Methocel
K100 MCR showed better dissolution properties compared to
formulaitons containing Methocel K15 MCR.It was found that
Hydrophilic polymers showed better released profile than the
hydrophobic polymers.
The environmental humanities-founded on the indivisible
human-environment nexus-focus on socioeconomic inequalities,
injustices, and various cultural differences to explain
environmental degradation and crises and to propose solutions. The
Bangladesh Environmental Humanities Reader: Environmental Justice,
Developmental Victimhood, and Resistance presents unique analyses
of Bangladesh's environment-development relationships. The book
looks at developmental victimhood, environmental injustices, and
resistance of the marginalized in Bangladesh. It reflects how the
popular GDP-based economic development model motivates governments
of Bangladesh to undertake infrastructural and "development"
projects, the growth of which threatens environment and livelihood
of the poorer sections while benefiting the affluent profiteers.
The book also critically engages with environmentalism represented
through the literary works in Bangla through tales of pollution,
depletion, and human-nature symbiosis, showing ways to achieve
social justice to resist victimhood through art. Moreover,
agricultural technologies shaped by cultivators-scientists'
collaborations are often helpful for biodiversity conservation,
notwithstanding those that ruin ecology and livelihood. Against the
backdrop of climate change challenges, this book shows how politics
and technology meet in many cross-cutting pathways.
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