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Toby K. Eisenstein Symposium Committee Chairperson Temple
University School of Medicine Philadelphia, Pennsylvania 19140 This
symposium is the thirteenth biennial clinical microbiology program
sponsored by the Eastern Pennsylvania Branch of the American
Society for Microbiology in cooperation with the Philadelphia area
medical schools and the Bureau of Laboratories of the Pennsylvania
Department of Health. This year a generous contribution from Merck,
Sharp and Dohme has helped to make the program a reality. The
subject matter for this symposium represents an attractive spectrum
of medical, biological and molecular approaches to the practical
solution of a public health prob1em--name1y, prevention of
infection with the hepatitis B virus. The symposium may be unique
in that it focuses on a product which was first marketed less than
three months ago, but included in the program are presen tations on
two new approaches to hepatitis B vaccine production which may
replace the one which is newly unveiled. The rapidity of progress
in our present era of biological research is indeed astonishing."
This volume represents the proceedings of the 2nd annual symposium
on the Brain Immune Axis and Substance Abuse held at the Breakers
Hotel in Palm Beach, FL in June 1994. The history of productive
studies concerning the relationship between the nervous and the
immune systems is relatively recent. Studies on the effects of
drugs of abuse on the immune system and on infections among
individuals who abuse drugs are also of recent vintage. Only in the
last decade have investigators begun to describe the role of drugs
of abuse and their endogenous counterparts on the brain-immune
axis. Thus, the involvement of the neuroendocrine system in the
interactions of drugs of abuse and the immune system has only
recently been appreciated. In addition, it has been recognized that
direct neural inputs impact immune function. Given the complexity
of these interactions, characterization of biologically significant
phenomena and elucidation of their mechanisms of action often
requires a multidisciplinary approach. This meeting, on which the
chapters in this book are based, brought together scientists from
an array of biomedical disciplines whose work is focused on the
effects of drugs of abuse on the neuro-endocrine immune axis. The
meeting was unique in focusing on the brain-immune axis from the
viewpoint of drugs of abuse rather than either immunity itself or
the brain itself. Presentations addressed the direct effects of
drugs of abuse on various components of the immune system, as well
as those mediated indirectly by the central nervous system and the
neuroendocrine system.
The subject matter of this volume was the basis for a confer ence
held in Philadelphia in June, 1981, and is an important one in the
contemporary area of how the host interacts with micro organisms.
In conception, it grew out of a graduate course entitled, "The
Infectious Process," which has been taught in the Department of
Microbiology and Immunology at Temple University School of Medicine
during the past twelve years. This course has explored the broad
areas of mechanisms of microbial pathogenesis and host resistance
by in-depth consideration of selected models of experimental
infection and immunity, as well as the clinical literature. It is
noteworthy that there is no adequate text for this material, as the
subject matter naturally crosses a wide spectrum of traditional
disciplinary lines, encompassing topics as diverse as the
mechanisms of action of bacterial toxins, the role of complement
and antibody in phagocytosis, and the importance of cross-reacting
bacterial polysaccharide antigens in vaccine development. A major
portion of the course has always considered "cellular immunity" as
it applies to host defenses to intracellular pathogens. It is in
this area that the necessity for amalgamation of information from
different disciplines is most evident, for one must be intimately
concerned with the interactions between the microbe and the
phagocyte, both before and after specific immune recognition."
This volume represents the Proceedings of the Symposium on AIDS,
Drugs of Abuse and the Neuroimmune Axis. This meeting was held in
San Diego, California, November 11-13, 1995. As in the previous
symposia in this series, productive studies were reviewed
concerning the relationship between the nervous and the immune
systems in regards to the relationship between drugs of abuse and
infections, especially infections by the immunode ficiency virus
that causes AIDS. In recent years, various investigators have begun
to describe the role of illicit drugs and their endogenous
counterparts on the brain-immune axis. It is widely recognized that
the neuroendocrine system is intimately involved in the effects and
manifestations of the interactions of drugs of abuse and the immune
system. The meeting on which the chapters in this book are based
brought together many biological scientists from an array of
various scientific disciplines whose work is focused on the effects
of drugs of abuse on the neuroendocrine-immune axis and its
relationships to immunodeficiency caused by the AIDS virus. As in
the past, the symposium was unique in focusing on the .
brain-immune axis from the viewpoint of drugs of abuse rather than
from the viewpoint of immunity or the brain itself."
Toby K. Eisenstein Symposium Committee Chairperson Temple
University School of Medicine Philadelphia, Pennsylvania 19140 This
symposium is the thirteenth biennial clinical microbiology program
sponsored by the Eastern Pennsylvania Branch of the American
Society for Microbiology in cooperation with the Philadelphia area
medical schools and the Bureau of Laboratories of the Pennsylvania
Department of Health. This year a generous contribution from Merck,
Sharp and Dohme has helped to make the program a reality. The
subject matter for this symposium represents an attractive spectrum
of medical, biological and molecular approaches to the practical
solution of a public health prob1em--name1y, prevention of
infection with the hepatitis B virus. The symposium may be unique
in that it focuses on a product which was first marketed less than
three months ago, but included in the program are presen tations on
two new approaches to hepatitis B vaccine production which may
replace the one which is newly unveiled. The rapidity of progress
in our present era of biological research is indeed astonishing."
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