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Heart Cell Coupling and Impulse Propagation in Health and Disease
includes an up-to-date review on how heart cells communicate and
impulse propagation under normal as well as under pathological
conditions. The complexity of intercellular coupling and impulse
propagation is discussed, providing the reader with a broad view of
the importance of these processes and how they contribute to the
generation of cardiac arrhythmias and heart failure. The different
aspects and intricacies of heart cell communication is discussed by
different authors, each one an expert in their own field. The
present publication will be of interest to cardiologists,
electrophysiologists, heart physiologists, cardiac pharmacologists,
biophysicists, and cell or molecular biologists.
Experimental and clinical evidence supports the view that the
activation of the renin angiotensin aldosterone system is involved
in cardiovascular pathology including hypertension, heart failure,
myocardial ischemia, and atherosclerosis. The present volume
describes the intricacies involved in these processes, including
the in?uence of prorenin/renin, angiotensin II, angiotensin (1-7),
and aldosterone on cardiac and vascular functions as well as their
involvement in the generation of cardiovascular diseases.
Fundamental aspects like intracellular signaling, regulation of
cell volume in the failing heart, and the presence of an intracrine
renin angiotensin system are discussed. Moreover, the role of the
mineralocorticoid receptor as an important c- ponent of the
intracrine renin angiotensin system and as a regulator of
extracellular action of angiotensin II is described, reinforcing
the view that aldosterone inhibitors are helpful in the treatment
of heart failure and hypertension. Let us hope the imp- tant topics
included here motivate basic and clinical investigators and
contribute to the development of new therapeutic approaches for
cardiovascular diseases. We want to thank the distinguished authors
and Humana Press for the opportunity to publish this important
book. Walmor C. DeMello Edward Frohlich v Contents 1 Systemic
Versus Local Renin Angiotensin Systems. An Overview ...1 Walmor C.
DeMello and Richard N. Re 2 Clinical Import of the Local Renin
Angiotensin Aldosterone Systems ...7 Edward D. Frohlich 3 Renin,
Prorenin, and the (Pro)Renin Receptor ...15 Genevieve Nguyen and
Aurelie Contrepas 4 Local Renin Angiotensin Systems in the
Cardiovascular System ...25 Richard N.
Grau. teurer Freund. ist aUe Theorie Und griln des Lebens goldner
Baum All theory. dear friend. is gray But the golden tree of actual
life springs ever green -Goethe Progress achieved in the last 25
years indicates that the establishment of inter- cellular junctions
at the area of cell contact represents an important mechanism of
intercellular communication. Evidence is available that
intercellular channels are essential for electrical synchronization
in excitable tissues and for the diffusion of molecules from cell
to cell. This process of cell-to-cell communication is so reliable
that it was pre- served throughout the evolutionary scale. As
evolution generates diversity it is not surprising that gap
junctions are not the same in all systems. It is known, for 2
instance, that junctional permeability is reduced by high free [Ca
+]j in some cells or by a fall in pHi in others, or enhanced by
cAMP. Our knowledge of the physiological modulators of junctional
permeability is still scanty. Moreover, the compartmentalization of
the intracellular milieu represents an additional complication in
the interpretation of many studies of cell-to-cell communication.
The present volume represents an effort to provide the reader with
an actualized view of the mechanisms of cell communication and of
the physiologi- cal and pathological implications of junctional and
nonjunctional communica- tion. Let us hope that the content of this
book helps future studies in establishing a better picture of the
cellular and molecular mechanisms involved in the process of
intercellular communication.
Experimental and clinical evidence supports the view that the
activation of the renin angiotensin aldosterone system is involved
in cardiovascular pathology including hypertension, heart failure,
myocardial ischemia, and atherosclerosis. The present volume
describes the intricacies involved in these processes, including
the in?uence of prorenin/renin, angiotensin II, angiotensin (1-7),
and aldosterone on cardiac and vascular functions as well as their
involvement in the generation of cardiovascular diseases.
Fundamental aspects like intracellular signaling, regulation of
cell volume in the failing heart, and the presence of an intracrine
renin angiotensin system are discussed. Moreover, the role of the
mineralocorticoid receptor as an important c- ponent of the
intracrine renin angiotensin system and as a regulator of
extracellular action of angiotensin II is described, reinforcing
the view that aldosterone inhibitors are helpful in the treatment
of heart failure and hypertension. Let us hope the imp- tant topics
included here motivate basic and clinical investigators and
contribute to the development of new therapeutic approaches for
cardiovascular diseases. We want to thank the distinguished authors
and Humana Press for the opportunity to publish this important
book. Walmor C. DeMello Edward Frohlich v Contents 1 Systemic
Versus Local Renin Angiotensin Systems. An Overview ...1 Walmor C.
DeMello and Richard N. Re 2 Clinical Import of the Local Renin
Angiotensin Aldosterone Systems ...7 Edward D. Frohlich 3 Renin,
Prorenin, and the (Pro)Renin Receptor ...15 Genevieve Nguyen and
Aurelie Contrepas 4 Local Renin Angiotensin Systems in the
Cardiovascular System ...25 Richard N.
In Heart Cell Communication in Health and Disease an extensive
review of different aspects of heart cell communication is
presented. The book starts with the fundamental concept that
cardiac cells are communicated, and then proceeds to the role of
gap junctions in heart development, the molecular biology of gap
junctions, the biophysics of the intercellular channels, the
control of junctional conductance and the influence of gap
junctions on impulse propagation. This is the first time that a
single volume has described cell communication in the normal heart
and under different pathological conditions such as heart failure,
coronary disease, myocardial ischemia and cardiac arrhythmias. In
this way the process of cell communication is analyzed at different
levels of complexity, providing the reader with a wide view of this
field and its relevance to cardiology.
In Heart Cell Communication in Health and Disease an extensive
review of different aspects of heart cell communication is
presented. The book starts with the fundamental concept that
cardiac cells are communicated, and then proceeds to the role of
gap junctions in heart development, the molecular biology of gap
junctions, the biophysics of the intercellular channels, the
control of junctional conductance and the influence of gap
junctions on impulse propagation. This is the first time that a
single volume has described cell communication in the normal heart
and under different pathological conditions such as heart failure,
coronary disease, myocardial ischemia and cardiac arrhythmias. In
this way the process of cell communication is analyzed at different
levels of complexity, providing the reader with a wide view of this
field and its relevance to cardiology.
Heart Cell Coupling and Impulse Propagation in Health and Disease
includes an up-to-date review on how heart cells communicate and
impulse propagation under normal as well as under pathological
conditions. The complexity of intercellular coupling and impulse
propagation is discussed, providing the reader with a broad view of
the importance of these processes and how they contribute to the
generation of cardiac arrhythmias and heart failure. The different
aspects and intricacies of heart cell communication is discussed by
different authors, each one an expert in their own field.
The present publication will be of interest to cardiologists,
electrophysiologists, heart physiologists, cardiac pharmacologists,
biophysicists, and cell or molecular biologists.
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