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Books > Science & Mathematics > Physics > Applied physics & special topics > Biophysics
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Cell-to-Cell Communication (Paperback, Softcover reprint of the original 1st ed. 1987)
Loot Price: R1,429
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Cell-to-Cell Communication (Paperback, Softcover reprint of the original 1st ed. 1987)
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Grau. teurer Freund. ist aUe Theorie Und griln des Lebens goldner
Baum All theory. dear friend. is gray But the golden tree of actual
life springs ever green -Goethe Progress achieved in the last 25
years indicates that the establishment of inter- cellular junctions
at the area of cell contact represents an important mechanism of
intercellular communication. Evidence is available that
intercellular channels are essential for electrical synchronization
in excitable tissues and for the diffusion of molecules from cell
to cell. This process of cell-to-cell communication is so reliable
that it was pre- served throughout the evolutionary scale. As
evolution generates diversity it is not surprising that gap
junctions are not the same in all systems. It is known, for 2
instance, that junctional permeability is reduced by high free [Ca
+]j in some cells or by a fall in pHi in others, or enhanced by
cAMP. Our knowledge of the physiological modulators of junctional
permeability is still scanty. Moreover, the compartmentalization of
the intracellular milieu represents an additional complication in
the interpretation of many studies of cell-to-cell communication.
The present volume represents an effort to provide the reader with
an actualized view of the mechanisms of cell communication and of
the physiologi- cal and pathological implications of junctional and
nonjunctional communica- tion. Let us hope that the content of this
book helps future studies in establishing a better picture of the
cellular and molecular mechanisms involved in the process of
intercellular communication.
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