This book summarizes all the important aspects of CRLs (Cullin-RING E3 Ubiquitin Ligases), while providing details of mechanistic specifics that go beyond protein ubiquitination and neddylation. Ubiquitin ligases, including the CRLs, which are activated by neddylation, play an important role in diverse biological processes and are involved in various human diseases, particularly cancer. The book covers various topics, such as CRL structure, biology, genetics, its regulation by neddylation, its pivotal role in human disease, and its potential in drug discovery and targeted therapies. The book appeals to biochemists and biologists working in other fields, and, given the importance of CRLs in all aspects of cell biology and the great promise of targeting these complexes for therapy, is a valuable resource anyone interested in modern biology or medicine.

This book summarizes all the important aspects of CRLs (Cullin-RING E3 Ubiquitin Ligases), while providing details of mechanistic specifics that go beyond protein ubiquitination and neddylation. Ubiquitin ligases, including the CRLs, which are activated by neddylation, play an important role in diverse biological processes and are involved in various human diseases, particularly cancer. The book covers various topics, such as CRL structure, biology, genetics, its regulation by neddylation, its pivotal role in human disease, and its potential in drug discovery and targeted therapies. The book appeals to biochemists and biologists working in other fields, and, given the importance of CRLs in all aspects of cell biology and the great promise of targeting these complexes for therapy, is a valuable resource anyone interested in modern biology or medicine.

This book features the latest advances and future trends in water science and technology. It also discusses the scientific popularization and quantitative resolution of a variety of mysterious properties of water and ice from the perspective of hydrogen-bond cooperativity in response to stimuli such as chemical contamination, electrification, magnetification, mechanical compression, molecular undercoordination, and thermal excitation. Anomalies include the floating of ice, the Hofmeister effect in solutions, regelation of ice, slipperiness of ice, water's tough skin, the Mpemba paradox, and the floating bridge. It also addresses the superfluidity of microchannels, hydrogen bond potentials, nanodroplet and bubble thermodynamics, quasisolidity and supersolidity, controlling superhydrophobicity-superhydrophilicity transition, and high-pressure ice formation. The target audience for this book includes students, senior scholars, engineers and practitioners in the area of physical chemistry, biology, as well as aqueous and colloid solutions.

This book features the latest advances and future trends in water science and technology. It also discusses the scientific popularization and quantitative resolution of a variety of mysterious properties of water and ice from the perspective of hydrogen-bond cooperativity in response to stimuli such as chemical contamination, electrification, magnetification, mechanical compression, molecular undercoordination, and thermal excitation. Anomalies include the floating of ice, the Hofmeister effect in solutions, regelation of ice, slipperiness of ice, water's tough skin, the Mpemba paradox, and the floating bridge. It also addresses the superfluidity of microchannels, hydrogen bond potentials, nanodroplet and bubble thermodynamics, quasisolidity and supersolidity, controlling superhydrophobicity-superhydrophilicity transition, and high-pressure ice formation. The target audience for this book includes students, senior scholars, engineers and practitioners in the area of physical chemistry, biology, as well as aqueous and colloid solutions.

This book constitutes the refereed proceedings of the 5th CCF China Blockchain Conference, CBCC 2022, held in Wuxi, China, in December 2022. The 7 revised full papers presented were carefully reviewed and selected from 67 submissions. The papers deal with research results and development activities in all aspects of blockchain science and technology.

This book adopts an integrative research framework that primarily combines industrial and discourse analysis to investigate the company Milkyway Image, drawing upon literature that studies film studios and the practices of film production, distribution, and reception. The history of the Hong Kong-based film production company Milkyway Image from its founding in 1996 to the present exemplifies the metamorphosis of the post-return Hong Kong film industry to an era characterised by Hong Kong's integration into a Chinese national context and the transnationalisation of world cinema. It shows that contemporary Hong Kong cinema's transition resists a monolithic chronicle and instead represents a narrative combining the perspectives of different interest groups and a complex process of compliance and resistance, negotiation and contestation. The meaning of Milkyway's films shifts as they are circulated across cultures and viewed within diverse frameworks, and our understanding of Hong Kong cinema is subject to varying contexts and historical configurations. For researchers in film and media studies and those who have a general interest in Hong Kong cinema, Asian cinema, or contemporary film culture, this book reveals how a variety of industry and cultural bodies have become co-creators of meaning for a film production house, and how the company operates as a co-creator of the discourse that surrounds it.

This book adopts an integrative research framework that primarily combines industrial and discourse analysis to investigate the company Milkyway Image, drawing upon literature that studies film studios and the practices of film production, distribution, and reception. The history of the Hong Kong-based film production company Milkyway Image from its founding in 1996 to the present exemplifies the metamorphosis of the post-return Hong Kong film industry to an era characterised by Hong Kong's integration into a Chinese national context and the transnationalisation of world cinema. It shows that contemporary Hong Kong cinema's transition resists a monolithic chronicle and instead represents a narrative combining the perspectives of different interest groups and a complex process of compliance and resistance, negotiation and contestation. The meaning of Milkyway's films shifts as they are circulated across cultures and viewed within diverse frameworks, and our understanding of Hong Kong cinema is subject to varying contexts and historical configurations. For researchers in film and media studies and those who have a general interest in Hong Kong cinema, Asian cinema, or contemporary film culture, this book reveals how a variety of industry and cultural bodies have become co-creators of meaning for a film production house, and how the company operates as a co-creator of the discourse that surrounds it.

This book constitutes the refereed proceedings of the Second CCF China Blockchain Conference, CBCC 2019, held in Chengdu, China, in October 2019. The 16 revised full papers presented were carefully reviewed and selected from 112 submissions. The papers deal with research results and development activities in all aspects of blockchain science and technology.

This book constitutes the proceedings of the 7th International Conference on Intelligence Science and Big Data Engineering, IScIDE 2017, held in Dalian, China, in September 2017.The 48 full papers and 14 short papers presented in this volume were carefully reviewed and selected from 121 submissions. They deal with statistics and learning; deep neural networks; faces and people; objects; classification and clustering; imaging; biomedical signal processing; and recommendation.

East Asia and the West: An Entangled History provides readers with a comprehensive overview of modern East Asian civilizations. The text demonstrates how China, Korea, Japan, and Vietnam developed into modern nations through interactions with Western ideas and military power. Part One of the text provides an overview and historical background of premodern East Asia, highlighting differences and similarities between China, Korea, Japan, and Vietnam, and significant partnerships and innovations from the 1500s to the 1800s. In Part Two, students learn why certain areas adopted an isolationist policy against Western influence, while others welcomed the influence. Part Three focuses on confrontation and Westernization, featuring discussion of the Opium Wars, the Meiji Transformation, and French colonization in Indochina. Part Four covers major events that occurred during World War II, including the communist movements in East Asia during the war. The final part examines the competition and confrontation between the capitalist and communist systems during the Cold War in East Asia. The text features transliteration notes, maps, and an expansive bibliography to provide students with a complete and immersive learning experience. East Asia and the West is part of the Cognella History of Asia Series, a collection of books dedicated to helping students explore the exciting, complex, and influential past of Asian countries.

Despite all the studies done so far in this field, the application of silver nanoparticles on photonics materials is a relatively new physical process. Therefore, it is quite normal that most of the work done so far has been devoted to the development and optimisation of the effect rather than to a deeper understanding of the mechanism of the physical process. This book discusses mechanistic aspects of the physical process between noble metallic nanoparticles on the photonics materials, which are plausible and in line with earlier and new findings of our group, as well as the comparison of these results with those of other groups.