Cullin-RING Ligases and Protein Neddylation - Biology and Therapeutics (Paperback, 1st ed. 2020)

This book summarizes all the important aspects of CRLs (Cullin-RING E3 Ubiquitin Ligases), while providing details of mechanistic specifics that go beyond protein ubiquitination and neddylation. Ubiquitin ligases, including the CRLs, which are activated by neddylation, play an important role in diverse biological processes and are involved in various human diseases, particularly cancer. The book covers various topics, such as CRL structure, biology, genetics, its regulation by neddylation, its pivotal role in human disease, and its potential in drug discovery and targeted therapies. The book appeals to biochemists and biologists working in other fields, and, given the importance of CRLs in all aspects of cell biology and the great promise of targeting these complexes for therapy, is a valuable resource anyone interested in modern biology or medicine.

General

Imprint:	Springer Verlag, Singapore
Country of origin:	Singapore
Series:	Advances in Experimental Medicine and Biology, 1217
Release date:	2021
First published:	2020
Editors:	Yi Sun • Wenyi Wei • Jianping Jin
Dimensions:	254 x 178mm (L x W)
Format:	Paperback
Pages:	372
Edition:	1st ed. 2020
ISBN-13:	978-981-15-1027-4
Categories:	Books > Medicine > General issues > Medical equipment & techniques > Medical research Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins Books > Science & Mathematics > Biology, life sciences > Cellular biology > General
LSN:	981-15-1027-X
Barcode:	9789811510274

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