This book is a volume in the Penn Press Anniversary Collection. To mark its 125th anniversary in 2015, the University of Pennsylvania Press rereleased more than 1,100 titles from Penn Press's distinguished backlist from 1899-1999 that had fallen out of print. Spanning an entire century, the Anniversary Collection offers peer-reviewed scholarship in a wide range of subject areas.

This book is an up-to-date, comprehensive review of the neuropsychiatry of multiple sclerosis and related diseases, by active authorities in the field, with an emphasis on diagnosis and management. Critical appraisal of the methodological aspects and limitations of the current research on the neuropsychiatry of demyelinating diseases is included, and unanswered questions are highlighted. Pharmacological aspects of management are discussed. Neuropsychiatric Symptoms of Inflammatory Demyelinating Diseases is aimed at neurologists, multiple sclerosis specialists and psychiatrists, and will also be of interest to intensive care doctors, psychologists ad neuropsychologists, research and specialist nurses, clinical researchers and methodologists.

Emergency departments around the world may differ, but many of the problems they face are the same. Written by an international panel of experienced emergency department leaders Emergency Department Leadership and Management provides the latest knowledge and advice to improve your personal leadership skills. The book will assist emergency department leaders in overcoming common management and operational problems including overcrowding, risk management, implementing the right triage system, electronic and IT solutions, improving clinical teamwork, education of emergency department staff, improving patient flow, care pathways and leading during times of change. Example cases are included to allow leaders to compare common cases to the problems which they face in their own departments. Information on designing emergency medicine specialty residency programs is also provided. It is the official text of the International Emergency Department Leadership Institute (IEDLI) and has been endorsed by the International Federation for Emergency Medicine (IFEM).

Critical Care Neurology, Part I: Neurocritical Care focuses on the care specialists and general neurologists that consult in the ICU and their work with patients in acute, life-threatening situations who are dealing with neurologic or neurosurgical crises emanating from either a preexisting neurologic syndrome or from a new neurologic complication appearing as a result of another medical or surgical critical illness. These two separate clinical situations form the pillars of neurocritical care, hence these practices are addressed via two separate, but closely related, HCN volumes. Chapters in both focus on pathophysiology and management, and are tailored for both general neurologists and active neurocritical specialists, with a specific focus on management over diagnostics. Part I addresses the principles of neurocritical care and the management of various neurologic diseases. Part II addresses the interplay between neurologic complications and the surgical, medical, cardiac, and trauma of critical illnesses that most typically present in the ICU.

The kidneys participate in all vital processes of the body to maintain overall homeostasis and health. When kidneys are injured during surgical interventions, metabolic and hemodynamic control is disrupted, leading to dysfunction associated with greater mortality, length of hospital stay and cost. Peri-operative Kidney Injury presents the epidemiology, risk factors, diagnosis, treatment and outcomes associated with kidney injury during the peri-operative period. Concepts and principles of care to prevent kidney complications during surgical procedures are provided to equip health care professionals along with strategies to manage acute kidney injury and associated challenges when they occur. Chapters detail diverse surgical settings, ranging from the more common, such as abdominal, cardiac and vascular surgeries, to the intricately complex, including the use of the left ventricular assist device and organ transplants. This practical and comprehensive text blends the evidence-based standards of care with cutting edge advances in the field, while also providing the reader with a peek into innovations on the horizon.

The third edition of the Color Atlas of Emergency Trauma brings the reader to the bedside of patients with traumatic injuries, at one of the largest and busiest trauma centers in North America. It includes over 1200 images, designed as a comprehensive visual and reference guide to emergency trauma care. Organized by major body regions, this atlas explores the full spectrum of common and uncommon traumatic injuries, including those caused by firearms, stab wounds, blunt trauma, crush injury, and burns. It also covers special patient groups, such as pregnant, pediatric and geriatric populations. Each chapter is augmented with patient images at presentation, radiographic, intraoperative and autopsy images, and color illustrations and photographs showing key anatomy from the cadaver laboratory. With common pitfalls discussed and invaluable tips from a multidisciplinary group of experienced trauma care providers, this book is a useful and practical resource for all those involved in trauma care.

As the number of people aged 65 years and above rises, physicians are increasingly confronted by elderly patients with impaired renal function, altered drug metabolism and multiple comorbidities. This book examines in detail the nature of renal injury in the elderly and its optimal management. A wide range of key topics are covered, including end-stage renal disease, diabetic nephropathy, acute kidney injury, drug metabolism and renal toxicity, dialysis and its complications and the use of renal transplantation. In addition, the assessment of glomerular filtration rate in the elderly and the role of novel renal biomarkers are carefully examined. Quality of life issues, the significance of other age-related medical problems and end of life care are also discussed. This book will be of value not only to nephrologists but also to general practitioners, medical students, intensivists, cardiologists, pharmacologists and those working in related specialties.

The critical care unit is an intense clinical environment with huge responsibilities on the professionals caring for these patients. Imaging is a key source of diagnostic information, but the conditions in which diagnostic imaging has to be performed are often extremely challenging and significantly different to imaging in the non acute setting. Imaging the ICU Patient reviews imaging procedures on the ICU in a highly practical and memorable manner. Swift and efficient clinical decision-making is rewarded on the ICU and this book serves as a practical handbook.

This book highlights the practical characteristics of uncommon diseases and presents the most relevant features for the management of intensive care units. It does not aim to provide an exhaustive description of uncommon diseases, focusing instead on the major diseases that intensivists may encounter in their clinical practice. After a brief introduction on the epidemiology and pathophysiology of each disease, the authors emphasize the aspects related to diagnosis and treatment, providing concise and pragmatic guidance for residents and intensivists who care for patients with uncommon diseases. Although by definition uncommon diseases have a low prevalence in the general population, they can affect a large number of patients admitted to intensive care units, as they can often be diagnosed at intensive care units. Indeed, often a complication of the disease is what leads to the patient's being admitted to an intensive care unit.

This book explains the chemistry of Organophosphorus compounds (OPs), their mechanism of toxicity and the history of OPs from their initial discovery to the development of new compounds such as Novichoks. It details the harmful effects to human health both as a result of acute and chronic OP exposure and the necessary clinical management of affected patients to reduce their toxic side effects. The book also explains the detrimental effect that OPs have had on the environment and the efforts being made to prevent this in the future. Finally, the book looks at the incidents where OPs have been used as chemical warfare agents. Basic and Clinical Toxicology of Organophosphorus Compounds aims to act as a comprehensive guide to all aspects of OPs and is a key resource for clinical toxicologists and related health professionals involved in the prevention, diagnosis and clinical management of OP patients, toxicologists and other scientists involved in research on OPs including regulatory issues and postgraduate students in Toxicology and related fields.

This book provides a detailed review of state of the art knowledge on critical care topics as well as the latest research findings. It covers the core aspects in excellent detail, but is not so comprehensive as to make its daily use unfeasible. For each condition considered, discussion of the pathophysiology is integrated with observations on diagnosis and treatment in order to allow a deeper understanding. The book is scientifically based, with extensive references to published research. This will allow readers to investigate their individual interests further and will enable physicians to justify measures by providing a coherent, evidence-based strategy and relevant citations where needed. Core Knowledge in Critical Care Medicine will appeal to experienced practitioners as an aide-memoire, but will also be of great value to a wide range of more junior staff wishing to complement their background knowledge with important facts applicable to everyday practice.

This book provides recommendations for evaluation and therapy in the area of acute pediatric neurology; these are presented didactically with frequent use of illustrations and algorithms. Chapters in the first part of the book discuss presenting symptoms of acute neurological conditions. The second part of the book covers major areas of acute pediatric neurology and each of these chapters has three key elements: description of presenting symptoms; recommended assessments; and recommended interventions. Acute Pediatric Neurology provides an accessible, clinically focused guide to assist physicians in the emergency ward or intensive care unit in decisions on diagnosis and therapeutic interventions in all major acute pediatric neurological diseases.

Geriatric Trauma and Critical Care provides a multidisciplinary overview of the assessment and management of the elderly patient presenting with surgical pathology. By utilizing current literature and evidence-based resources, the textbook elucidates the unique nature of caring for the elderly population. The structure of the volume provides the reader with an overview of the physiologic and psychological changes, as well as the impact on the healthcare system, associated with the aging process. Emphasis is placed on the impact of aging, pre-existing medical problems, effects of polypharmacy, advanced directives and end-of-life wishes on acute surgical problems, including trauma and surgical critical care. Special attention is given to the ethical implications of management of the aged. The multidisciplinary contributors provide a unique point of view not common to surgical texts. The textbook is the definitive resource for practicing surgeons, emergency medicine physicians, intensivists, anesthesiologists, hospitalists, geriatricians, as well as surgical residents, nurses and therapists, all who care for elderly patients with surgical emergencies.

Disaster Preparedness for Seniors: A Comprehensive Guide for Healthcare Professionals outlines specific disaster scenarios for homebound, community, hospitalized, long term care, homeless and aged veterans. Chapters are written by a diverse group of authors, all of whom offer insight and expertise in training healthcare professionals in preparing for disasters. Topics include myths and realities of natural disasters and disaster preparedness for special populations of elders-the acute care elderly, the community-dwelling elderly, home based primary care senior veterans, the immune-compromised elderly, those with multiple and co morbid illnesses, the long-term care elderly, those elderly at the end of life and the effects of disaster on caregivers. A significant portion of the book is also devoted to training, competencies, literacy, cultural competency and resilience in disaster preparedness as well as the role of the academic medical center. The volume concludes with coverage of the management of behavioral, medical and psychological consequences of disasters. Disaster Preparedness for Seniors: A Comprehensive Guide for Healthcare Professionals is an important new volume and will serve as a guide for the development of programs, policies and procedures for evacuation of seniors during various disaster scenarios.

This book is unique in approaching multiple organ dysfunction syndrome (MODS) from the perspective of its pathophysiological mechanism, and addressing aspects that are overlooked in most of the available literature. Eminent experts in the field from Europe and beyond offer new insights into risk stratification, severity assessment, and management of critically ill patients with sepsis. The principal focus is on recently developed concepts in infection management and in antibiotic use, bearing in mind that in these patients the pharmacokinetics of antibiotics are altered, affecting renal clearance and requiring dosage adjustments. The significance of the PIRO (predisposing factors, infection, response, organ dysfunction) model in the development of effective treatment strategies is emphasized. This book will be of interest and value to all who are involved in the treatment of, or research into, sepsis and MODS.

1. Features recent developments like 3-D surgery, telescopic IOL, bionic implants and robotic surgery. 2. Highlights case selection and important precautions to be taken by vitreoretinal surgeons and senior residents. 3. Covers the controversies surrounding primary VR versus RD surgery in Phakic, fresh retinal detachments; Positioning after macular hole/ VR surgery; and to peel or not peel ILM in non-macular hole retinal surgery.

Infants and children are at high risk of acquiring infections and this is most critical on the pediatric intensive care unit, as these infections have serious effects on mortality. Infectious Diseases in the Pediatric Intensive Care Unit is the first to provide a thorough review of this most important area of intensive care medicine with an emphasis on evidence-based medicine.

This volume is a comprehensive, state-of-the-art review for clinicians with an interest in the peri-operative nutritional management of all surgical patients. The text reviews normal physiology, the pathophysiology of starvation and surgical stressors, and focuses on appropriate nutritional repletion for various common disease states. Specifically, the text addresses the severe metabolic demands created by systemic inflammation, infection, and major insults such as trauma and burns. In addition, the book addresses the growing problem of obesity in surgical populations, including appropriate strategies directed towards the metabolic management of these patients. The text is designed for clinicians across levels of training and provides clear and concise evidence based guidelines for the metabolic management and nutritional support of the surgical patient. Written by experts in the field, Surgical Metabolism: The Metabolic Care of the Surgical Patient is a valuable resource for all clinicians involved in the care of the critically ill.

Urology is a speciality that notoriously receives little attention in medical school, yet it makes up a sizeable portion of the workload in emergency departments and also in primary care. Urological emergencies can often be managed simply but require the appropriate knowledge and skills. Emergency urology is often covered very superficially alongside general surgery or in excessive detail within voluminous urology textbooks. This book is different: it will consist of concise, well-structured chapters, with an accessible and easily digestible style. The content will be clinically-based and will include a number of clinical photographs and radiological investigations. This book will appeal to all doctors, including those rotating through surgical and emergency medicine specialities, and those clinicians approaching professional examinations worldwide. Medial students on urology or emergency medicine placements, who are studying for their exams will also find it invaluable. In addition, primary care doctors, speciality nurses in urology and nurses in emergency department may also appreciate the clinically relevant content of the book. The authors are all dedicated to education and teaching, and have published extensively. In addition, they run a successful emergency urology course in Cambridge, popular with clinicians and senior students alike.

Prehospital Care of Neurologic Emergencies is a reliable and definitive resource for emergency medical services personnel at multiple levels; physicians, paramedics, nurses and others who encounter these critically ill patients. This focused and succinct book addresses the management of a wide range of neurologic emergencies, including traumatic brain injuries, spinal cord injuries, strokes, and seizures. In these emergencies time is critical, and the simply presented, straightforward format of the patient care and management recommendations help readers to treat patients rapidly and confidently. Each chapter follows a standard format that includes an overview of each neurologic emergency, important background, key challenges, and areas requiring future investigation. This book is unlikely to be placed on your bookshelf; instead, you will keep it nearby for times when you face life-threatening neurologic emergencies. When seconds count, this book has the answers.

Posttraumatic Growth reworks and overhauls the seminal 2006 Handbook of Posttraumatic Growth. It provides a wide range of answers to questions concerning knowledge of posttraumatic growth (PTG) theory, its synthesis and contrast with other theories and models, and its applications in diverse settings. The book starts with an overview of the history, components, and outcomes of PTG. Next, chapters review quantitative, qualitative, and cross-cultural research on PTG, including in relation to cognitive function, identity formation, cross-national and gender differences, and similarities and differences between adults and children. The final section shows readers how to facilitate optimal outcomes with PTG at the level of the individual, the group, the community, and society.

Through case presentations and a question and answer format, Clinical Decisions in Nephrology, Hypertension and Renal Transplantation provides a state of the art, updated reference for the optimal management of patients with diseases of the kidneys, and hypertension. This volume starts with the assessment of the patient, focusing on history and physical examination. Subsequently, cases depicting various clinical syndromes and/or diseases are presented, with questions centering on the appropriate diagnostic and treatment strategy. This sets the stage for a 'Socratic approach' to learning between the attending physician and the house staff or medical student. This is the only book featuring problem-oriented true to life clinical cases in this format to cover nephrology, hypertension and kidney transplantation. Written by renowned actively practicing clinicians, this unique reference is both comprehensive and concise and will be of great value to hospitalists and internists, as well as students, and interns/residents rotating in nephrology and internal medicine. Clinical practitioners, in the fields of critical care and hypertension specialists would also find this of value.

The past few decades have seen major impacts of different pandemics and mass casualty events on health resource use in terms of rising healthcare costs and increased mortality. In this context, the development of acute respiratory failure in patients requires the use of mechanical ventilation, either invasive or noninvasive. Recently, noninvasive ventilation (NIV) has proved to be a valuable strategy to reduce mortality rates in patients. This is the first book to describe the clinical indications of NIV in patients who have been hospitalized with high-risk infections as well as in the prehospital management of mass casualty incidents, including chemical or biological disasters and pandemics. Compiled by internationally respected experts, it offers comprehensive coverage of all aspects of noninvasive mechanical ventilation in public health emergencies, such as equipment needs and guidelines for health organizations. Considering recent events (SARS, H1N1 influenza pandemic), the book concludes with a critical review of current studies and future prospects for the use of NIV, offering a valuable resource for all practitioners managing mass casualty incidents and disasters.

Modern vascular neurology, particularly in the emergency setting, often requires a great capacity for analysis and synthesis. Physicians who manage these patients must have acquired multidisciplinary skills, including a good knowledge of clinical neurology and medical imaging, but they may also need to be skilled in cardiology and intensive care. The initial clinical and imaging examinations play a decisive role in the management strategy. This book, written by neurologists and neuroradiologists, is designed to help all physicians involved in the management of neurovascular disease. The format and contents of this book, including the latest guidelines from learned societies, are designed to provide a succinct and practical guide. Although this book is particularly devoted to ischaemic stroke, other neurovascular diseases, especially haemorrhagic stroke, are also discussed. This book should constitute a valuable tool for everyday practice for all medical personnel involved in neurovascular disease.

In response to persistent donor organ shortages, organs from marginal donors, such as expanded criteria donors (ECD) and donation after cardiac death (DCD) donors, are now accepted and have been successfully transplanted, reducing the waiting times for transplantation. Especially in Japan, transplantation of DCD kidneys has a relatively long history because of the difficulty or lack of national consensus in accepting brain death, which has made it possible to accumulate considerable clinical experience. Thus, the current organ shortage has stimulated interest in the use of marginal donors for transplantation. On the other hand, however, it is known that these organs have a high rate of delayed graft function and a more complicated postoperative course. These drawbacks have created the greatest clinical challenge in transplantation to date because of the current shortage and limitations of donors using ECD and DCD. This book, prepared by distinguished authorities in their fields, is intended for clinicians and researchers. It highlights the use of marginal donors as a comparatively novel source of transplantation organs and provides a thorough overview of marginal donors from their historical origins to recent clinical applications, including the state-of-the-art science of organ/donor management, procurement, and preservation. Also provided is valuable information on ABO-incompatible donors which extend the availability of donor sources. Each chapter offers an individual analysis of the optimal requirements for the safe management and preservation of organs, including the heart, lung, liver, kidney, pancreas, and pancreatic islets.