Definitive yet concise, Food Allergy, by Drs. John M. James, Wesley Burks, and Philippe Eigenmann, provides expert guidance for efficient diagnosis and effective management of these increasingly prevalent conditions. The consistent, practical format, with a wealth of case studies, clinical pearls and pitfalls, full-color photos and illustrations, diagrams, and more - along with online access at www.expertconsult.com - make this an ideal quick reference tool for both allergy clinicians and primary care physicians. Quickly reference essential topics thanks to a templated, focused format that includes a wealth of full-color photos and illustrations, diagrams, case studies, and more. Benefit from the knowledge, experience, and global perspective of leading international authors. Deliver the best outcomes by incorporating clinical pearls from experts in the field into your practice. Stay current with timely topics including our latest understanding of non-IgE-mediated food allergies; cross-reactions; future therapies; natural history and prevention; and a review of unproven diagnostic and therapeutic techniques. Access this reference online at ExpertConsult.com, complete with the full text, entire image bank, and more. The tools you need to quickly and accurately diagnose, treat, and manage food allergies.

The number of people suffering from Multiple Chemical Sensitivity (MCS) is greater than the number suffering from AIDS, yet the general public and the medical community know very little about the disease. More and more people are disabled daily, despite the fact that the condition does not have to occur. In Part One of this work, experts review the research into the disease, along with treatment strategies. Part Two examines the legal recourses available to MCS sufferers, such as workers' compensation claims and product liability suits. How the medical community has often worked against MCS sufferers is the focus of Part Three, demonstrating that medical opposition to the disease is unfounded. The editor, an MCS sufferer, details her own case in Part Four.

Dr. Coppes and his co-Editors have created a comprehensive table of contents that addresses the full spectrum of food allergies in children. Articles are presented to be most useful to pediatricians, as the issue begins with the clinical presentation and epidemiology of food allergy, and then progresses to the diagnostic testing and pahthophysiology.? Articles are also included that are devoted to specific types of food allergy, dairy, soy, egg, peanut, and tree nut. Finally, articles are also devoted to living with food allergies, management of allergies in schools and camps, and therapies for food allergies.

Dr Werner Pichler has developed an issue of top specialists discussing Drug Hypersensitvity. Topics include: "Approach to the patient with drug allergy," "Perioperative anaphylaxis," "Basophil activation test in drug allergy," "In vitro tests," "Desensitizations," and more

More than two decades into the global HIV epidemic, many HIV positive patients who have access to antiretroviral medications are graying. These patients and their clinicians now face another set of complex health issues related to aging. HIV and Aging examines the known effects of HIV and HIV medications on older patients and on their immune systems. The book explores the coalescence of aging and HIV on neurologic, psychiatric, cardiovascular, endocrine, renal, and pulmonary systems and oncology.

Written by some of today 's top experts, HIV and Aging answers questions like:

• What are the similarities with immune system changes that occur with aging and those associated with HIV?
• What effects do HIV and HIV medications have on cardiovascular health?
• What do we know about drug interactions between antiretrovirals and medicines used to treat diseases of aging?

Systemic autoimmune diseases can affect both the central and peripheral nervous systems in a myriad of ways and through a heterogeneous number of mechanisms leading to many different clinical manifestations. As a result, neurological complications of these disorders can result in significant morbidity and mortality. Advances in the diagnosis, laboratory investigations, and management of these conditions has placed an increasing burden on the practicing clinician to correctly assess and treat these patients.
This volume of the Handbook of the Systemic Autoimmune Diseases will help the clinician and researcher better understand the current concepts of nervous system involvement from systemic autoimmune disorders, recognize current approaches to diagnosis and treatment, current controversies, and areas that need significant research efforts. It is believed that providing this approach in a single volume will facilitate its use as a frequent resource for all those caring for or investigating these patients and their diseases.
Each chapter follows a consistent outline to provide the reader with important and useful information in an easy-to-navigate manner and is also liberally referenced to provide more primary source material for further consideration. The standardized approach to each chapter will allow the reader to be able to compare and contrast more efficiently the neurological complications of the autoimmune diseases discussed.

Introduction; L.C. Chen, et al. Epidemiolgy and Policy: AIDS and Reproductive Health; K. LaGuardia. Policy and Legal Aspects of AIDS Interventions; H. Fineberg. Risk Factors in Transmission: Factors Affecting Female-to-Male Transmission of HIV1; F.A. Plummer, et al. Interrelationships Between HIV Infection and Other STDs; J. Wasserheit. Contraception, Family Planning, and HIV; D. Hunter, J.K.G. Mati. Perinatal Transmission: Mother to Fetus/Infant Transmission of HIV1; O. Meirik. HIV Perinatal Transmission and Reproductive Health; P. Kanki, et al. Methods for Decreasing HIV Transmission to Infants; S.J. Heymann. Interventions: An Overview of AIDS Interventions in High-Risk Groups; P. Lamptey. Intervention Research Needs for AIDS Prevention Among Commercial Sex Workers and Their Clients; B. de Zalduondo, et al. 7 additional articles. Index.

Now available in its Third Edition, Asthma: Basic Mechanisms and Clinical Management has become "the" reference text in asthma. This highly successful text sheds new light on the basic physiological and molecular mechanisms of asthma, how current treatments work, and how best to apply the latest knowledge to control this important disease. The Third Edition has undergone radical revision and includes several new chapters. It retains the virtues of the previous volumes by bringing together all of the recent research findings by internationally recognized experts on the causative mechanisms of asthma, including in-depth clinical aspects and therapy. The book presents an integrated approach toward the treatment of this disease with new concepts, changes in asthma management, and the development of new therapeutic agents. Asthma provides extensive references for researchers and clinicians who need to keep abreast of recent developments in this rapidly expanding field.
Key Features
* Comprehensive coverage of both basic science and clinical aspects of asthma
* Extensively referenced throughout

Empasizing advances in local cell recruitment, this text offers coverage of the cells, mechanisms and proteins involved in allergic inflammation. It provides over 2200 bibliographic citations; overviews of adhesion molecule biology; and lists of molecular nomenclature and function.

This 3rd edition provides updated information on side effects of cosmetic products, topical and systemic drugs used in dermatology, and other therapeutic modalities used by dermatologists including PUVA therapy and (new in this edition) dermal implants, laser therapy, chemical face peels and cryotherapy.

Because of the explosion of new knowledge since the last edition (the 2nd edition of this book was published 8 years ago), the section on cosmetics has largely been rewritten and extended, the section on side effects of systemic drugs used in dermatology has also been expanded, and the index of drugs has been made comprehensive.

This book will be of great value to the practising physician who is confronted with a (possible) adverse reaction to a cosmetic or drug used in dermatological practice as well as to those who are scientifically interested, by providing access to recent relevant literature.

This volume covers advances in the field of respiratory diseases, reflecting the recent and dramatic expansion of knowledge regarding the determinants of respiratory health, screening tests for early pulmonary lesions, therapeutic interventions for respiratory infections and strategies for prevention. It examines indoor and outdoor environmental sources of respiratory diseases, including levels of pollutants, air conditioning, indoor air quality and airborne allergens. Exploring ways to promote the respiratory health of both the individual and the community, Prevention of Respiratory Diseases covers areas including: the role of most of the known extrinsic and potentially preventable determinants in respiratory diseases; developments in epidemiology and children's respiratory health; the relationship between respiratory diseases and occupations; individual sensitivity or susceptibility to the effects of air pollutants; genetic, epidemiological and immunological markers, markers for bronchial cancer and the protease-antiprotease system; and the connection between tobacco smoke and respiratory diseases.;This resource is intended for pulmonologists, clinical immunologists and allergists, oncologists, physiologists, infectious disease specialists, respiratory therapists and graduate and medical school students in these disciplines.

This book explores the recent advances and integrations in molecular technology in food research platforms, which have revolutionized the way we discover and trace potential allergens in our food and drugs and how we utilize that for diagnosis and management. These different technologies for global allergenomic profiling in different kinds of food are discussed, including mass spectrometry, chromatography, and nuclear magnetic resonance. The book also addresses multiomics research with bioinformatics strategies in food allergy in terms of allergen characterization and quantitation, and covers applications in food allergy research from discovery to routine analysis.

When I entered the field of allergy in the early 1970s, the standard textbook was a few hundred pages, and the specialty was so compact that texts were often authored entirely by a single individual and were never larger than one volume. Compare this with Allergy Frontiers: Epigenetics, Allergens, and Risk Factors, the present s- volume text with well over 150 contributors from throughout the world. This book captures the explosive growth of our specialty since the single-author textbooks referred to above. The unprecedented format of this work lies in its meticulous attention to detail yet comprehensive scope. For example, great detail is seen in manuscripts dealing with topics such as "Exosomes, naturally occurring minimal antigen presenting units" and "Neuropeptide S receptor 1 (NPSR1), an asthma susceptibility gene." The scope is exemplified by the unique approach to disease entities normally dealt with in a single chapter in most texts. For example, anaphylaxis, a topic u- ally confined to one chapter in most textbooks, is given five chapters in Allergy Frontiers. This approach allows the text to employ multiple contributors for a single topic, giving the reader the advantage of being introduced to more than one vi- point regarding a single disease.

Essential Oils: Contact Allergy and Chemical Composition provides a full review of contact allergy to essential oils along with detailed analyses of the chemical composition of essential oils known to cause contact allergy. In addition to literature data, this book presents the results of nearly 6,400 previously unpublished sample analyses, by far the largest set of essential oils analyses ever reported in a single source of scientific literature. Covering 91 essential oils and two absolutes, the book presents an alphabetical list of all 4,350 ingredients that have been identified in them, a list of chemicals known to cause contact allergy and allergic contact dermatitis, and tabular indications of the ingredients that can be found in each essential oil. The book discusses contact allergy and allergic contact dermatitis for each of the oils and absolutes, sometimes able to provide only one or two reports but drawing upon considerable amounts of literature in other cases, such as with tea tree oil, ylang-ylang oil, lavender oil, rose oil, turpentine oil, jasmine absolute, and sandalwood oil. While limited information on the main components and their concentrations would be enough for most dermatologists, this book gives extensive coverage not only to improve levels of medical knowledge and quality of patient care, but also for the benefit of professionals beyond clinical study and practice, such as chemists in the perfume and cosmetics industries, perfumers, academic scientists working with essential oils and fragrances, aromatherapists, legislators, and those involved in the production, sale, and acquisition of essential oils. Key Features: Provides a full literature review of contact allergy to and chemical composition of 91 essential oils and two absolutes Presents the largest set of analytical reports on essential oils in scientific literature to date Provides tables of all chemicals which can be found in each essential oil with concentrations Presents an alphabetical list of 4,350 ingredients identified in the oils and absolutes with their synonyms and specifying in which oils each chemical can be present Provides a tabular list of all known allergens to the oils discussed Includes reference tables on the quantitative composition of essential oils that are of regulatory use to the fragrance industry Covers an extensive amount of information to benefit non-medical professionals involved with the research, production, distribution, and use of essential oils and products containing essential oils

A breathtaking one in five people in the U.S. has a health condition related to food-from disruptive sensitivities and intolerances to serious allergic reactions that can send them to the ER. These food-related problems are on a historic rise across all ages. And the spectrum of these ailments is wide and deep, with many tricky "masqueraders" in the mix to create a lot of confusion, potential misdiagnoses, and faulty or poor treatment-and immeasurable suffering for millions of people. The good news: Dr. Ruchi Gupta, on the front lines of this silent epidemic, now shares revolutionary research from her lab and clinical practice. In Food Without Fear, Dr. Gupta illuminates this misunderstood spectrum and offers a new approach to managing adverse reactions to food with a practical plan to end the misery and enjoy eating with ease. This panoramic view empowers you to know what questions to ask your doctor to get the correct diagnosis. From debunking common myths (an allergy and an intolerance aren't the same thing-but both can have life-threatening consequences) to identifying masqueraders, to understanding triggers (including environmental factors), as well as the microbiome's role in adverse food reactions, these pages hold the answers. Using a framework of Identify and Empower, Treat, Manage and Prevent, and Thrive, Food Without Fear offers hope, help-and food freedom-to the millions of people who so need it. Developed by world-renowned researcher Dr. Ruchi Gupta, this revolutionary spectrum approach empowers and informs so you can take charge of your health. In Food Without Fear, you'll learn: - The differences between an allergy and an intolerance or sensitivity - What "masqueraders" are and how to identify them - Which health conditions are mistaken for food allergies-or can be triggered by them - The top offenders that can spark an allergy attack or intolerance - The surprising allergies on the rise (think red meat and exercise) - The potential connections between genetics, environmental exposures, and risk for developing food-related conditions - How to S.T.O.P. the misery and chart your healthy path forward Offering assessments, information on the most up-to-date treatments, and practical tips for keeping yourself safe, Food Without Fear welcomes you back to the table.

To some, food allergies seem like fabricated cries for attention. To others, they pose a dangerous health threat. Food allergies are bound up with so many personal and ideological concerns that it is difficult to determine what is medical and what is myth. Another Person's Poison parses the political, economic, cultural, and genuine health factors of a phenomenon that dominates our interactions with others and our understanding of ourselves. For most of the twentieth century, food allergies were considered a fad or junk science. While many physicians and clinicians argued that certain foods could cause a range of chronic problems, from asthma and eczema to migraines and hyperactivity, others believed that allergies were psychosomatic. 'This book traces the trajectory of this debate and its effect on public-health policy and the production, manufacture, and consumption of food. Are rising allergy rates purely the result of effective lobbying and a booming industry built on self-diagnosis and expensive remedies? Or should physicians become more flexible in their approach to food allergies and more careful in their diagnoses? Exploring the issue from scientific, political, economic, social, and patient-centered perspectives, this book is the first to engage fully with the history of a major modern affliction, illuminating society's troubled relationship with food, disease, nature, and the creation of medical knowledge.

This volume provides protocols for mouse models of allergic diseases and guidelines for choosing a particular strains, allergen, adjuvant, and route of sensitization. Chapters detail types of allergic disease, methods that are frequently employed to analyze pathophysiology of allergic diseases, manipulation of intestinal microbiota, and desensitization of immure responses in animal models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Animal Models of Allergic Disease: Methods and Protocols aims to offer a comprehensive collection of protocols and experience-derived instructions to further allergic disease research.

Investigative Immunotoxicology provides a critical evaluation of proposed experimental animal models and approaches, and discusses the contribution that immunotoxicity can make to the overall assessment of chemical-induced adverse health effects on humans and the ecosystem. Following a review of general concepts in immunotoxicology, the book discusses emerging methodologies at the cellular and molecular levels, and describes advances in and requirements for animal model development in testing the allergenicity of foods and genetically modified products. It presents animal models of autoimmunity associated with chemical exposure, includes recommendations for the selection of sentinel species in ecotoxicology, and presents an in-depth review of immunotoxicology as it relates to a variety of wildlife species. Finally, the book explains the role of immunotoxicology in human health risk assessment and the regulatory process. Outlining the potential chemical hazards facing human and ecosystem health, this is a valuable reference for professionals and researchers in immunotoxicology and risk assessment. It also deserves the attention of the pharmaceutical industry and environmental toxicologists who are concerned about the effects of xenobiotics on ecosystems.

This book sums up the mechanistic basis, current status, and future prospects of steroid inhalation as the cornerstone of prophylactic asthma therapy, identifying its kinetic basis-especially the essential airway selectivity-and including a historical account of inhaled glucocorticoid development. Makes connections among the underlying pharmacology, impact of new simulation models, newly recognized molecular targets, and therapeutic outcomes of short- and long-term steroid inhalation therapy! Containing more than 1600 works cited, drawings, tables, equations, and micrographs, Inhaled Steroids in Asthma -describes the developmental history of inhaled steroids and provides general models for lung selectivity -considers the best way to select inhaled steroids -clarifies local metabolism, airway and lung uptake and retention, and other determinants of once-daily usage -addresses variations in lung deposition and total bioavailability among available steroids and formulations -surveys the dynamics of receptor gene-mediated processes -analyzes the role of chemokines in airway allergic inflammatory diseases -discusses the effects of inhaled steroids in vivo on cell progenitors in asthma and rhinitis -details measuring airway inflammation as a guide for treatment decisions -outlines the clinical relevancy of exhaled nitric oxide in asthma -covers optimal trial design for judging antiasthmatic potency and efficacy -evaluates the safety of inhaled steroids Written by more than 40 of the world's leading authorities and investigators, Inhaled Steroids in Asthma is an authoritative reference for pulmonologists and pulmonary disease specialists; physiologists; allergists; immunologists; molecular, cell, and lung biologists; pediatricians; pharmaceutical scientists and pharmacologists; and medical school and upper-level undergraduate, graduate, and medical school students in these disciplines.

Contains patterns of allergic reactivity for disorders such as asthma, atopic dermatitis, urticaria, and anaphylaxis!
Written by leading experts in the field, Inflammatory Mechanisms in Allergic Diseases covers
non-anaphylactic drug disorders
synthesis and formation of IgE antibodies
new treatments using allergenic peptides, immunostimulatory oligonucleotides, and pharmacogenomics
recent advances targeting effector mechanisms
hypersensitivity reactions to drugs
and more!
With over 3100 references, tables, drawings, and micrographs, Inflammatory Mechanisms in Allergic Diseases is an essential reference for allergists, pulmonologists, immunologists, dermatologists, ophthalmologists, otolaryngologists, internists, pediatricians, family practitioners, and medical students in these disciplines.

This is a comprehensive guide to the wide variety of allergic diseases in existence. The book opens with a general chapter on diagnostic tes ting for allergy, covering both in vivo and in vitro tests. Separate c hapters are then devoted to a wide range of allergies, including asthm a, rhinitis, anaphylaxis, and drug, food and latex allergies. Each cha pter is sub-divided into sections covering classification, diagnosis a nd management of the various conditions. The result is a comprehensive and practical guide which will appeal, not only to the allergology sp ecialist, but also to the wide variety of physicians who may be called upon to recognise and treat patients presenting with allergic conditi ons.

Presents classic and recent findings on immunological dysfunctions caused by food allergies-coordinating the most advanced clinical techniques and assessment methods with practical insights for treatment and patient care.

This work presents the proceedings of a conference held at Adare Manor, County Limerick, Ireland. It provides an updated, in-depth review of the biological role of eosinophils in allergic diseases, summarizing basic knowledge of these unique cationic proteins. The book features an annotated discussion of the conference's post-presentation question-and-answer session.

This book will address the growing roles of epigenetics in disease pathogenesis, and review the contribution of epigenetic modifications to disease onset and progression. The roles that epigenetics plays in facilitating effects of the environment on allergy and immunologic diseases will be reviewed. The book is divided into three parts - the first is an introduction to epigenetics and the methods that have been developed to study epigenetics, the second addresses epigenetics in allergic diseases and the third part will cover epigenetics in autoimmune diseases. With the rapid expansion of knowledge of how genes are regulated and how this regulation affects disease phenotypes, this book will be attractive to experienced researchers as well as those just launching an epigenetics research program. It will also be of interest to allergist, immunologists, rheumatologists and dermatologist who are engaged in clinical practice as a resource for understanding the basis for personalized and precision medicine. For example, the role that epigenetics plays in the pathogenesis in various allergic and autoimmune disorders and how this determines disease phenotypes will be covered extensively in this book. This book will thus help fill the gap in available resources on epigenetics in allergy and autoimmune diseases.

This book contains twelve chapters contributed by prestigious international experts who are at the forefront of B cell research, and aims to provide a cutting-edge and comprehensive overview of all aspects of B cells, including B cell development, maturation and activation, germinal center reaction, memory and plasma cell differentiation, and antibody-mediated positive and negative regulation of humoral immune responses. There are also three chapters describing human diseases caused by B cell abnormalities, including primary antibody deficiencies, autoimmune diseases, and B cell malignancies. We hope that this book will become a standard and routine reference for both basic researchers and clinicians.