This book sums up the mechanistic basis, current status, and future prospects of steroid inhalation as the cornerstone of prophylactic asthma therapy, identifying its kinetic basis-especially the essential airway selectivity-and including a historical account of inhaled glucocorticoid development. Makes connections among the underlying pharmacology, impact of new simulation models, newly recognized molecular targets, and therapeutic outcomes of short- and long-term steroid inhalation therapy! Containing more than 1600 works cited, drawings, tables, equations, and micrographs, Inhaled Steroids in Asthma -describes the developmental history of inhaled steroids and provides general models for lung selectivity -considers the best way to select inhaled steroids -clarifies local metabolism, airway and lung uptake and retention, and other determinants of once-daily usage -addresses variations in lung deposition and total bioavailability among available steroids and formulations -surveys the dynamics of receptor gene-mediated processes -analyzes the role of chemokines in airway allergic inflammatory diseases -discusses the effects of inhaled steroids in vivo on cell progenitors in asthma and rhinitis -details measuring airway inflammation as a guide for treatment decisions -outlines the clinical relevancy of exhaled nitric oxide in asthma -covers optimal trial design for judging antiasthmatic potency and efficacy -evaluates the safety of inhaled steroids Written by more than 40 of the world's leading authorities and investigators, Inhaled Steroids in Asthma is an authoritative reference for pulmonologists and pulmonary disease specialists; physiologists; allergists; immunologists; molecular, cell, and lung biologists; pediatricians; pharmaceutical scientists and pharmacologists; and medical school and upper-level undergraduate, graduate, and medical school students in these disciplines.

Contains patterns of allergic reactivity for disorders such as asthma, atopic dermatitis, urticaria, and anaphylaxis!
Written by leading experts in the field, Inflammatory Mechanisms in Allergic Diseases covers
non-anaphylactic drug disorders
synthesis and formation of IgE antibodies
new treatments using allergenic peptides, immunostimulatory oligonucleotides, and pharmacogenomics
recent advances targeting effector mechanisms
hypersensitivity reactions to drugs
and more!
With over 3100 references, tables, drawings, and micrographs, Inflammatory Mechanisms in Allergic Diseases is an essential reference for allergists, pulmonologists, immunologists, dermatologists, ophthalmologists, otolaryngologists, internists, pediatricians, family practitioners, and medical students in these disciplines.

This is a comprehensive guide to the wide variety of allergic diseases in existence. The book opens with a general chapter on diagnostic tes ting for allergy, covering both in vivo and in vitro tests. Separate c hapters are then devoted to a wide range of allergies, including asthm a, rhinitis, anaphylaxis, and drug, food and latex allergies. Each cha pter is sub-divided into sections covering classification, diagnosis a nd management of the various conditions. The result is a comprehensive and practical guide which will appeal, not only to the allergology sp ecialist, but also to the wide variety of physicians who may be called upon to recognise and treat patients presenting with allergic conditi ons.

Essential Reading for Every Parent In the early 1990s, tens of thousands of children with severe peanut and food allergies arrived for kindergarten at schools in Canada, the United Kingdom, Australia, and the United States. The phenomenon of a life-threatening allergy in kids in only these countries occurred simultaneously, without warning, and it quickly intensified. The number of peanut allergic children in the United States alone went from virtually none to about two million in just twenty years. As these children have aged, the combined number of American adults and children allergic to peanuts has grown to a total of four million. How and why has this epidemic occurred? In The Peanut Allergy Epidemic, Heather Fraser explains: Precisely when the peanut allergy epidemic began How a child-specific allergy epidemic happened before, at the close of the nineteenth century That in the early twentieth century doctors including the 1913 Nobel Prize in medicine winner identified vaccination as the cause of the first pediatric allergy epidemic impacting 50 percent of children That more than one hundred years of medical literature describes how vaccination creates allergy to what is in the shot, air, or body at the time of injection How changes in US vaccination legislation sparked the allergy epidemic in children Fraser also highlights alternative medicines and explores issues of vaccine safety and other food allergies, making this fully updated second edition a must-read for every parent, teacher, and health professional.

Presents classic and recent findings on immunological dysfunctions caused by food allergies-coordinating the most advanced clinical techniques and assessment methods with practical insights for treatment and patient care.

Whatever affects one part of the respiratory system may affect all other parts. It's common for an allergy that festers to lead to sinusitis and then to asthma. But all these conditions involve your whole body. That's why you need to learn how to engage the healing attributes of your entire body to cure the full range of respiratory problems. As a longtime, highly regarded practitioner, Dr. Grossan has adopted a holistic methodology for allergy and sinus health in addition to conventional medical practices. He advocates what he calls the "Whole Body Approach" (WBA) that includes "tools needed to take charge of your own healing." For instance, to promote natural healing in the nose, Dr. Grossan recommends humming, because "the vibration of the sound stimulates your nasal cilia [tiny hairs] to move faster" which "breaks up thick mucus that may impede cilia movement" following an allergy season. Humming loudly and in a low frequency - such as ooommmm - doesn't allow harmful bacteria to build up which can produce the toxins that cause sinus disease. Dr. Grossan, also, recommends using pulse-wave nasal irrigation and drinking hot lemon/lime drinks or teas with honey for positive cilia movement and allergy relief. Dr. Grossan bases his WBA on new discoveries about how the body heals, particularly psychoneuroimmunology, the study of the interaction between psychological processes and the nervous and immune systems. Relaxation, smiling, humour, biofeedback and five-sensory visualisation are in this tool kit. Some WBA activities he suggests are common-sense practices. For instance, when dealing with a seasonal allergy, avoid getting chilled and get good sleep. While Dr. Grossan discusses sound, time-tested medical practices for everything from sinus headaches to postnasal drip, chronic obstructive pulmonary disease, pollution-induced bronchial inflammation, asthma, snoring, loss of smell or taste, surgery and paediatric issues, he raises WBA for every issue. Lacing the text with humorous examples of how unconventional healing techniques cured people, Dr. Grossan has written a comprehensive review of the latest treatments, both holistic and medical, for the full range of respiratory ailments.

This work presents the proceedings of a conference held at Adare Manor, County Limerick, Ireland. It provides an updated, in-depth review of the biological role of eosinophils in allergic diseases, summarizing basic knowledge of these unique cationic proteins. The book features an annotated discussion of the conference's post-presentation question-and-answer session.

Only in very recent times have therapies been developed that are specific to a particular manifestation of autoimmune disease, and these have begun to replace the all-purpose remedies of the past 30 years. This volume, which draws on the principles of immunology presented in Volume 1050 ("Autoimmunity: Concepts and Diagnosis at the Cutting Edge"), extends these concepts to the realm of clinical findings and current therapy for many autoimmune and connective tissue disorders.

Both organ-specific and organ-nonspecific diseases are covered, and one section is entirely focused on treatment. Treatments using cytokines, chemokines, cognate receptors, and genetic interactions are particularly prominent in these reports, and attention is also paid to the increasing use of intravenous imunoglobulins and both monoclonal and imunosuppressive agents. A therapeutic void remains, but the work reported on here contributes considerably to the effort to fill that void.

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Chemical Intolerance identifies phenolic (aromatic) chemical compounds present in natural foodstuffs, pollens, certain food additives, tobacco smoke, perfumes, air pollution, etc., as nonimmunologic, but pharmacologic activators of allergic reactions in chemically intolerant individuals. Biochemical pathway sequences, with supporting scientific literature, are outlined to elucidate the mechanisms associated with formation of inflammatory mediators (prostaglandins, thromboxanes, and leukotrienes) upon activation by phenolic compounds and other chemical stimulants. The role of these inflammatory agents in respiratory, gastrointestinal, neurological, cardiovascular, and other disorders is discussed. Treatment modalities using precise dosages of selected phenolic compounds are outlined to provide clinicians with an effective means of therapy. The author also shares his own experience and personal findings based on 20 years of research, including his recommendations for therapy.

A food allergen has the ability to first elicit an IgE response, and then, on subsequent exposures, a clinical response to the same or similar protein. How harmless food protein becomes recognized by the mucosal immune system as an allergen remains an open question and more data are needed to explain how regulatory mechanisms of the mucosal immune system fail and result in allergic sensitization to dietary antigens. Some biochemical characteristics associated with food allergens, such as the presence of multiple, linear IgE-binding epitopes and the resistance of the protein to digestion and processing, seem to predominate among food allergens. Digestion susceptibility of food allergens that sensitize via the gastrointestinal tract and stability to food processing conditions are inherently related to protein structural features. Thereby, physiological changes in the digestion process, pathological conditions affecting digestion, as well as procedures and food processing conditions that affect protein structure may all have a profound effect on the sensitizing potential and allergenicity of food proteins. In addition, signals coming from the diet and micro biome can modulate regulatory mechanisms of the mucosal immune system and influence mucosal immunity and intestinal barrier function. The detection of allergenic ingredients in food products has received increased attention from the food industry and legislative and regulatory agencies over recent years. This has resulted in the improvement of applied safety measures that provide protection for food-allergic consumers and development of sensitive and highly specific analytical methods of food allergens detection. Food allergy is an important and common health issue and therefore there is a need to characterize the sensitizing potential of newly introduced proteins in genetically engineered foods. A combination of in vitro and in silico methods provide information that contributes to safety assessment. Suitable in vivo models may provide a more holistic assessment of allergenic potential of novel food proteins.

"Cooking Gluten-free is as easy as 1-2-3...4" "INGREDIENTS"
Imagine mouthwatering Buckwheat Pancakes, Sun-Dried Pesto Pasta, Pork with Parmesan Polenta, and a decadent serving of Orange Ricotta Pudding. All can be prepared using four or fewer ingredients--gluten-free
Kim McCosker and Rachael Bermingham, the internationally bestselling authors who brought you "4 Ingredients," have once again created more than 400 quick, easy, and delicious recipes that require only four ingredients. This time, however, they all meet the specific requirements for a gluten-free diet. Included are fantastic dishes for breakfast, lunch, dinner, and entertaining, as well as gluten-free lunch box meals and recipes for babies and toddlers.
With "4 Ingredients Gluten-Free," home chefs will learn how to:
- Make weeknight family dinners simple, special, and healthy for anyone in the family who is gluten intolerant.
- Provide delicious, home-cooked meals and spend less money.
- Cook with fewer utensils--1 teaspoon, 1 tablespoon, and 1 measuring cup
- Spend less time at the sink. Four ingredients for each dish means less cleanup
Find out what home chefs all over the world have already discovered. "4 Ingredients Gluten-Free "is perfect for the busy, budget-conscious, health-minded cook

Allergy and Allergic Diseases has been organized to provide an up-to-date, clinically relevant compilation of one of the most exciting areas of investigation in medicine today-allergic disease, especially as it pertains to the skin, airways, and bowel. With the dramatic rise in the incidence of various allergic disorders worldwide, and the coming of age of the discipline of Clinical Immunology and Allergy, the interface between basic and clinical science in this arena demands highlighting in this comprehensive new syn thesis.1t is with the hope of filling this evident need that Allergy and Allergic Diseases: The New Mechanisms and Therapeutics has been put together. The book's content is divided into both basic and clinical sections, with emphasis on various components of the immune and inflammatory response as they relate to the development of allergic disease. Topics span the range from molecular biology to clinical symptomatology, with an effort to make this of interest to as broad a constituency as possible. This book will therefore be of substantial interest to specialists in Clinical Immunology and Allergy, scientists studying the cellular and molecular biology of in flammation and immunity, as well as internists, teachers, developers of medical school curricula, and members of industry focused on drug discovery and therapeutics. Indeed, a separate section has been added to deal with some specific issues in this latter field."

From asthma to Crohn's disease, everyone knows someone who suffers from an allergic or autoimmune disorder. And if it appears that the prevalence of these maladies has increased recently, that's because it has--to levels never before seen in human history. These days no fewer than one in five--and likely more--Americans suffers from one of these ailments. We seem newly, and bafflingly, vulnerable to immune system malfunction. Why? One possibility is that we have systematically cleaned ourselves to illness; this belief challenges deeply entrenched notions about the value of societal hygiene and the harmful nature of microbes. Yet scientists investigating the rampant immune dysfunction in the developed world have inevitably arrived at this conclusion. To address this global "epidemic of absence," they must restore the human ecosystem.
This groundbreaking book explores the promising but controversial "worm therapy"--deliberate infection with parasitic worms--in development to treat autoimmune disease. It explains why farmers' children so rarely get hay fever, why allergy is less prevalent in former Eastern Bloc countries, and how one cancer-causing bacterium may be good for us. It probes the link between autism and a dysfunctional immune system. It investigates the newly apparent fetal origins of allergic disease--that a mother's inflammatory response imprints on her unborn child, tipping the scales toward allergy.
"An Epidemic of Absence" is a brilliant, cutting-edge exploration of the dramatic rise of allergic and autoimmune diseases and the controversial, potentially groundbreaking therapies that scientists are developing to correct these disorders.

This comprehensive book presents an evidence-based approach to treating asthma in adults aged 65 and older, a vulnerable subset of patients who are more likely to experience higher morbidity and mortality rates, and often enduring higher financial burdens related to treatment. Treatment of Asthma in Older Adults: A Comprehensive, Evidence-Based Guide is a unique resource, providing an up-to-date review of medication strategies, how asthma phenotypes and treatment decisions interact, and how controlling asthma triggers impacts long-term asthma outcomes in older patients. Additionally, the book incorporates recent advances in alternative therapies that improve the patient's quality of life. Opening discussions address the unique challenges of the differential diagnosis of asthma in older adults, as well as an examination of the significant medical comorbidities that co-exist with asthma. Subsequent chapters provide strategies to optimizing asthma management in this specific population, including information on case management that will assist allied health providers. Finally, the book closes with an analysis of several novel targets for therapy to treat severe asthma including biologics, macrolides and bronchial thermoplasty. Written by experts in the field, Treatment of Asthma in Older Adults: A Comprehensive, Evidence-Based Guide is an indispensable resource for allergists, pulmonologists, family physicians, physician assistants, nurse practitioners and all other allied clinicians.

Leading clinical experts survey the latest information available on the key rheumatic and allergic issues that physicians face in treating the HIV-infected patient. The physicians focus on the rheumatologic and dermatologic manifestations of HIV-1 infection, which include arthritis, myopathies, vasculitis, sicca syndrome, other autoimmune phenomena, and psoriasis. They also examine the question of allergic reactions in HIV patients, including drug hypersensitivity, with special attention given to adverse reactions to trimethoprim-sulfamethoxazole, the most frequently prescribed anti-infective. Practical advice for the diagnosis and treatment of these problems is given in full.

Challenging Cases in Allergic and Immunologic Diseases of the Skin offers clinicians a wide range of challenging cases that are certain to provide hours of thoughtful and instructive review. Using a case study format and including excellent quality color images, Challenging Cases in Allergic and Immunologic Diseases of the Skin consists of five parts and 20 chapters. The chapters cover such areas as allergic rhinitis, allergic diseases of the eye, drug-induced urticaria, cosmetic allergy, drug allergy, latex allergy, atopic dermatitis, vasculitis, and a range of other commonly seen disorders of the skin. Each chapter comprises at least two cases that are followed by a differential diagnosis, discussion, and five multiple choice questions for thoughtful stimulation and excellent value as a teaching tool. Comprehensive, concise, and well-designed in presentation, Challenging Cases in Allergic and Immunologic Diseases of the Skin is a one-of-a-kind resource that will become a standard resource for all clinicians who care for patients with allergic and immunologic diseases of the skin.

Over 90 percent of the population suffers from inflammation or an autoimmune disorder. Until now, conventional medicine has said there is no cure. Minor irritations like rashes and runny noses are ignored, while chronic and debilitating diseases like Crohn's and rheumatoid arthritis are handled with a cocktail of toxic treatments that fail to address their root cause. But it doesn't have to be this way.

In The Autoimmune Solution, Dr. Amy Myers, a renowned leader in functional medicine, offers her medically proven approach to prevent a wide range of inflammatory-related symptoms and diseases, including allergies, obesity, asthma, cardiovascular disease, fibromyalgia, lupus, IBS, chronic headaches, and Hashimoto's thyroiditis.

Diagnosis and Treatment of Fungal Infections, 2nd Edition is a thorough update to Diagnosis and Treatment of Human Mycoses. Globally recognized experts are brought together again to provide the latest research and clinical evidence on fungal infections and basic mycology. This concise text is divided into sections dedicated to the patient approach, laboratory and radiological diagnosis, antifungal agents, mycoses and instructive cases. Ideal for patient care or as a teaching guide, the busy infectious disease, hematology, oncology, pulmonology, or critical care specialist will find this resource to be a practical tool for diagnosing, treating, and managing patients with fungal infections.

Food allergy is an adverse immunological reaction to allergens present in food. Up to 4% adults and 8% children are affected by food allergy. The increase in allergic diseases to food has led to the need for better diagnostics and more effective therapeutic approaches. This book describes the molecular biology and immunology of major food allergens, from laboratory based science to clinical immunology, encompassing novel characterisation and quantification methods, the application of recombinant food allergens in molecular diagnosis and the development of novel therapeutics. This book is the ideal reference tool for researchers, students and allergy clinicians to accurately diagnose and manage food allergies.

Ditch processed foods and feed yourself and your family the cleanest, healthiest food on the planet by stocking your kitchen, shopping and cooking with Food Babe Kitchen. Over 100 mouthwatering recipes from Healing Turmeric Hummus and Glowing Green Juice to Sweet Potato Waffles with Cinnamon Whipped Butter and Almond Butter Freezer Fudge will show readers how delicious and simple it is to eat healthy, real food. Easy-to-follow directions, eye-catching photography and simple substitutions to accommodate vegan, dairy-free, grain-free and other diets, make this the ultimate guide to getting back into the kitchen to create healthful meals for yourself and those you love. Say good-bye to the Standard American Diet and set your own standards for your health! Now in paperback.

This book, besides reviewing basic and clinical aspects of Behcet's disease, covers the latest findings, including genetic studies and treatment with biologics for the disease. Although the cause of Behcet's disease is still unknown, it is well known that genetic factors, such as HLA-B51, are involved in its development. Recently, novel susceptibility loci including IL10, IL23R-IL12RB2, and endoplasmic reticulum aminopeptidase 1 have been identified, providing new insights into the pathogenesis of the disease. In addition to basic research, the beneficial efficacy of anti-TNF-alpha monoclonal antibodies has also been suggested for not only uveitis associated with the disease but also other subtypes of the disease such as entero-, vasculo-, and neuro- Behcet's disease. Behcet's Disease: From Genetics to Therapies provides essential information both for basic researchers working in the fields of immunology, inflammation, and genetics, and for clinical physicians who are interested in Behcet's disease, such as ophthalmologists, rheumatologists, dermatologists, gastroenterologists, neurologists, and vascular surgeons.

Primary immunodeficiency diseases (PIDs) are a heterogeneous group of inherited disorders characterized by different defects in the development and function of the immune system. This book aims to increase the clinical awareness and knowledge of practicing clinicians regarding the diagnosis and management of PIDs. In order to achieve this goal, about 90 cases drawn from real life are presented, along with approximately 300 related questions. The selected case reports are the result of the invaluable cooperation of more than 40 scientists in the field of immunodeficiency. They focus both on the presenting features of patients with PIDs and on the required further investigation and management. Each of the numbered cases is followed by the questions, their answers, and additional discussion. Each question focuses on a particular aspect of the PID under consideration, and the topics covered include clinical diagnosis, laboratory findings, molecular mechanisms, and therapy.

Skin physiology assessment is moving rapidly from a descriptive approach to a deeper understanding of biophysical and biochemical processes in the stratum corneum, e.g. on stratum corneum barrier function as well on stratum corneum hydration. The research with bioengineering methods offers now reliable and reproducible approaches for product testing in the pharmaceutical and cosmetic industry as well as in basic research. This cookbook is intended to give basic information regarding skin physiology, the assessment of skin functions in controlled studies using non-invasive biophysical instruments. It provides basic knowledge on how to plan, perform and evaluate scientific studies. The authors are recognized expert in the field and provide comprehensive chapters with specific emphasis on the practical aspects of non-invasive measurements.

Cytokines and cytokine receptors remain an area of great interest for the development of targeted therapies for cutaneous inflammatory diseases. Anti-TNF therapeutics have proven to be effective in the treatment of psoriasis, and clinical investigations have now begun for other cytokine-directed therapies, such as those targeting IFN-g, IL-12p40, and IL-18. In addition to therapeutics that target cytokines directly, strategies that target cytokine signaling pathways are in development. This book summarizes the findings of the 56th International Workshop of the Ernst Schering Research Foundation that focused on "Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases".