This book provides a generalised approach to fractal dimension theory from the standpoint of asymmetric topology by employing the concept of a fractal structure. The fractal dimension is the main invariant of a fractal set, and provides useful information regarding the irregularities it presents when examined at a suitable level of detail. New theoretical models for calculating the fractal dimension of any subset with respect to a fractal structure are posed to generalise both the Hausdorff and box-counting dimensions. Some specific results for self-similar sets are also proved. Unlike classical fractal dimensions, these new models can be used with empirical applications of fractal dimension including non-Euclidean contexts. In addition, the book applies these fractal dimensions to explore long-memory in financial markets. In particular, novel results linking both fractal dimension and the Hurst exponent are provided. As such, the book provides a number of algorithms for properly calculating the self-similarity exponent of a wide range of processes, including (fractional) Brownian motion and Levy stable processes. The algorithms also make it possible to analyse long-memory in real stocks and international indexes. This book is addressed to those researchers interested in fractal geometry, self-similarity patterns, and computational applications involving fractal dimension and Hurst exponent.

This new edition of a successful, bestselling book continues to provide you with practical information on the use of statistical methods for solving real-world problems in complex industrial environments. Complete with examples from the chemical and pharmaceutical laboratory and manufacturing areas, this thoroughly updated book clearly demonstrates how to obtain reliable results by choosing the most appropriate experimental design and data evaluation methods.

Unlike other books on the subject, Statistical Methods in Analytical Chemistry, Second Edition presents and solves problems in the context of a comprehensive decision-making process under GMP rules: Would you recommend the destruction of a $100,000 batch of product if one of four repeat determinations barely fails the specification limit? How would you prevent this from happening in the first place? Are you sure the calculator you are using is telling the truth? To help you control these situations, the new edition:

• Covers univariate, bivariate, and multivariate data
• Features case studies from the pharmaceutical and chemical industries demonstrating typical problems analysts encounter and the techniques used to solve them
• Offers information on ancillary techniques, including a short introduction to optimization, exploratory data analysis, smoothing and computer simulation, and recapitulation of error propagation
• Boasts numerous Excel files and compiled Visual Basic programs–no statistical table lookups required!
• Uses Monte Carlo simulation to illustrate the variability inherent in statistically indistinguishable data sets

Statistical Methods in Analytical Chemistry, Second Edition is an excellent, one-of-a-kind resource for laboratory scientists and engineers and project managers who need to assess data reliability; QC staff, regulators, and customers who want to frame realistic requirements and specifications; as well as educators looking for real-life experiments and advanced students in chemistry and pharmaceutical science.

From the reviews of Statistical Methods in Analytical Chemistry, First Edition:

"This book is extremely valuable. The authors supply many very useful programs along with their source code. Thus, the user can check the authenticity of the result and gain a greater understanding of the algorithm from the code. It should be on the bookshelf of every analytical chemist. "—Applied Spectroscopy

"The authors have compiled an interesting collection of data to illustrate the application of statistical methods . . . including calibrating, setting detection limits, analyzing ANOVA data, analyzing stability data, and determining the influence of error propagation." —Clinical Chemistry

"The examples are taken from a chemical/pharmaceutical environment, but serve as convenient vehicles for the discussion of when to use which test, and how to make sense out of the results. While practical use of statistics is the major concern, it is put into perspective, and the reader is urged to use plausibility checks."& mdash;Journal of Chemical Education

"The discussion of univariate statistical tests is one of the more thorough I have seen in this type of book.... The treatment of linear regression is also thorough, and a complete set of equations for uncertainty in the results is presented.... The bibliography is extensive and will serve as a valuable resource for those seeking more information on virtually any topic covered in the book."—Journal of American Chemical Society

This book treats the application of statistics to analytical chemistry in a very practical manner. [It] integrates PC computing power, testing programs, and analytical know-how in the context of good manufacturing practice/good laboratory practice (GMP/GLP).... The book is of value in many fields of analytical chemistry and should be available in all relevant libraries." —Chemometrics and Intelligent Laboratory Systems

This volume reports results from the German research initiative MUNA (Management and Minimization of Errors and Uncertainties in Numerical Aerodynamics), which combined development activities of the German Aerospace Center (DLR), German universities and German aircraft industry. The main objective of this five year project was the development of methods and procedures aiming at reducing various types of uncertainties that are typical of numerical flow simulations. The activities were focused on methods for grid manipulation, techniques for increasing the simulation accuracy, sensors for turbulence modelling, methods for handling uncertainties of the geometry and grid deformation as well as stochastic methods for quantifying aleatoric uncertainties.

This volume provides a unique collection of mathematical tools and industrial case studies in digital manufacturing. It addresses various topics, ranging from models of single production technologies, production lines, logistics and workflows to models and optimization strategies for energy consumption in production. The digital factory represents a network of digital models and simulation and 3D visualization methods for the holistic planning, realization, control and ongoing improvement of all factory processes related to a specific product. In the past ten years, all industrialized countries have launched initiatives to realize this vision, sometimes also referred to as Industry 4.0 (in Europe) or Smart Manufacturing (in the United States). Its main goals are * reconfigurable, adaptive and evolving factories capable of small-scale production * high-performance production, combining flexibility, productivity, precision and zero defects * energy and resource efficiency in manufacturing None of these goals can be achieved without a thorough modeling of all aspects of manufacturing together with a multi-scale simulation and optimization of process chains; in other words, without mathematics. To foster collaboration between mathematics and industry in this area the European Consortium for Mathematics in Industry (ECMI) founded a special interest group on Math for the Digital Factory (M4DiFa). This book compiles a selection of review papers from the M4DiFa kick-off meeting held at the Weierstrass Institute for Applied Analysis and Stochastics in Berlin, Germany, in May 2014. The workshop aimed at bringing together mathematicians working on modeling, simulation and optimization with researchers and practitioners from the manufacturing industry to develop a holistic mathematical view on digital manufacturing. This book is of interest to practitioners from industry who want to learn about important mathematical concepts, as well as to scientists who want to find out about an exciting new area of application that is of vital importance for today's highly industrialized and high-wage countries.

This is the first book devoted to the task of computing integrability structures by computer. The symbolic computation of integrability operator is a computationally hard problem and the book covers a huge number of situations through tutorials. The mathematical part of the book is a new approach to integrability structures that allows to treat all of them in a unified way. The software is an official package of Reduce. Reduce is free software, so everybody can download it and make experiments using the programs available at our website.

The subject of fractional calculus and its applications (that is, convolution-type pseudo-differential operators including integrals and derivatives of any arbitrary real or complex order) has gained considerable popularity and importance during the past three decades or so, mainly due to its applications in diverse fields of science and engineering. These operators have been used to model problems with anomalous dynamics, however, they also are an effective tool as filters and controllers, and they can be applied to write complicated functions in terms of fractional integrals or derivatives of elementary functions, and so on.This book will give readers the possibility of finding very important mathematical tools for working with fractional models and solving fractional differential equations, such as a generalization of Stirling numbers in the framework of fractional calculus and a set of efficient numerical methods. Moreover, we will introduce some applied topics, in particular fractional variational methods which are used in physics, engineering or economics. We will also discuss the relationship between semi-Markov continuous-time random walks and the space-time fractional diffusion equation, which generalizes the usual theory relating random walks to the diffusion equation. These methods can be applied in finance, to model tick-by-tick (log)-price fluctuations, in insurance theory, to study ruin, as well as in macroeconomics as prototypical growth models.All these topics are complementary to what is dealt with in existing books on fractional calculus and its applications. This book was written with a trade-off in mind between full mathematical rigor and the needs of readers coming from different applied areas of science and engineering. In particular, the numerical methods listed in the book are presented in a readily accessible way that immediately allows the readers to implement them on a computer in a programming language of their choice. Numerical code is also provided.

This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models. The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.

Reliability and Safety of Complex Technical Systems and Processes offers a comprehensive approach to the analysis, identification, evaluation, prediction and optimization of complex technical systems operation, reliability and safety. Its main emphasis is on multistate systems with ageing components, changes to their structure, and their components reliability and safety parameters during the operation processes. Reliability and Safety of Complex Technical Systems and Processes presents integrated models for the reliability, availability and safety of complex non-repairable and repairable multistate technical systems, with reference to their operation processes and their practical applications to real industrial systems. The authors consider variables in different operation states, reliability and safety structures, and the reliability and safety parameters of components, as well as suggesting a cost analysis for complex technical systems. Researchers and industry practitioners will find information on a wide range of complex technical systems in Reliability and Safety of Complex Technical Systems and Processes. It may prove an easy-to-use guide to reliability and safety evaluations of real complex technical systems, both during their operation and at the design stages.

Quarks are the main constituents of protons and neutrons and hence are important building blocks of all the matter that surrounds us. However, quarks have the intriguing property that they never appear as isolated single particles but only in bound states. This phenomenon is called confinement and has been a central research topic of elementary particle physics for the last few decades. In order to find the mechanism that forbids the existence of free quarks many approaches and ideas are being followed, but by now it has become clear that they are not mutually exclusive but illuminate the problem from different perspectives. Two such confinement scenarios are investigated in this thesis: Firstly, the importance of Abelian field components for the low-energy regime is corroborated, thus supporting the dual superconductor picture of confinement and secondly, the influence of the Gribov horizon on non-perturbative solutions is studied.

This volume gathers contributions reflecting topics presented during an INDAM workshop held in Rome in May 2016. The event brought together many prominent researchers in both Mathematical Analysis and Numerical Computing, the goal being to promote interdisciplinary collaborations. Accordingly, the following thematic areas were developed: 1. Lagrangian discretizations and wavefront tracking for synchronization models; 2. Astrophysics computations and post-Newtonian approximations; 3. Hyperbolic balance laws and corrugated isometric embeddings; 4. "Caseology" techniques for kinetic equations; 5. Tentative computations of compressible non-standard solutions; 6. Entropy dissipation, convergence rates and inverse design issues. Most of the articles are presented in a self-contained manner; some highlight new achievements, while others offer snapshots of the "state of the art" in certain fields. The book offers a unique resource, both for young researchers looking to quickly enter a given area of application, and for more experienced ones seeking comprehensive overviews and extensive bibliographic references.

This book introduces the novel concept of a fuzzy network whose nodes are rule bases and the connections between the nodes are the interactions between the rule bases in the form of outputs fed as inputs. The concept is presented as a systematic study for improving the feasibility and transparency of fuzzy models by means of modular rule bases whereby the model accuracy and efficiency can be optimised in a flexible way. The study uses an effective approach for fuzzy rule based modelling of complex systems that are characterised by attributes such as nonlinearity, uncertainty, dimensionality and structure.The approach is illustrated by formal models for fuzzy networks, basic and advanced operations on network nodes, properties of operations, feedforward and feedback fuzzy networks as well as evaluation of fuzzy networks. The results are demonstrated by numerous examples, two case studies and software programmes within the Matlab environment that implement some of the theoretical methods from the book. The book shows the novel concept of a fuzzy network with networked rule bases as a bridge between the existing concepts of a standard fuzzy system with a single rule base and a hierarchical fuzzy system with multiple rule bases.

The book comprises contributions by some of the most respected scientists in the field of mathematical modeling and numerical simulation of the human cardiocirculatory system. It covers a wide range of topics, from the assimilation of clinical data to the development of mathematical and computational models, including with parameters, as well as their efficient numerical solution, and both in-vivo and in-vitro validation. It also considers applications of relevant clinical interest. This book is intended for graduate students and researchers in the field of bioengineering, applied mathematics, computer, computational and data science, and medicine wishing to become involved in the highly fascinating task of modeling the cardiovascular system.

This book contains a collection of papers presented at the 2nd Tbilisi Salerno Workshop on Mathematical Modeling in March 2015. The focus is on applications of mathematics in physics, electromagnetics, biochemistry and botany, and covers such topics as multimodal logic, fractional calculus, special functions, Fourier-like solutions for PDE's, Rvachev-functions and linear dynamical systems. Special chapters focus on recent uniform analytic descriptions of natural and abstract shapes using the Gielis Formula. The book is intended for a wide audience with interest in application of mathematics to modeling in the natural sciences.

In this volume cultural, social and cognitive influences on the research and teaching of mathematical modelling are explored from a variety of theoretical and practical perspectives. The authors of the current volume are all members of the International Community of Teachers of Mathematical Modelling and Applications, the peak research body in this field. A distinctive feature of this volume is the high number of authors from South American countries. These authors bring quite a different perspective to modelling than has been showcased in previous books in this series, in particular from a cultural point of view. As well as recent international research, there is a strong emphasis on pedagogical issues including those associated with technology and assessment, in the teaching and learning of modelling. Applications at various levels of education are exemplified. The contributions reflect common issues shared globally and represent emergent or on-going challenges.

This book surveys significant modern contributions to the mathematical theories of generalized heat wave equations. The first three chapters form a comprehensive survey of most modern contributions also describing in detail the mathematical properties of each model. Acceleration waves and shock waves are the focus in the next two chapters. Numerical techniques, continuous data dependence, and spatial stability of the solution in a cylinder, feature prominently among other topics treated in the following two chapters. The final two chapters are devoted to a description of selected applications and the corresponding formation of mathematical models. Illustrations are taken from a broad range that includes nanofluids, porous media, thin films, nuclear reactors, traffic flow, biology, and medicine, all of contemporary active technological importance and interest. This book will be of value to applied mathematicians, theoretical engineers and other practitioners who wish to know both the theory and its relevance to diverse applications.

This book presents the latest research advances in complex network structure analytics based on computational intelligence (CI) approaches, particularly evolutionary optimization. Most if not all network issues are actually optimization problems, which are mostly NP-hard and challenge conventional optimization techniques. To effectively and efficiently solve these hard optimization problems, CI based network structure analytics offer significant advantages over conventional network analytics techniques. Meanwhile, using CI techniques may facilitate smart decision making by providing multiple options to choose from, while conventional methods can only offer a decision maker a single suggestion. In addition, CI based network structure analytics can greatly facilitate network modeling and analysis. And employing CI techniques to resolve network issues is likely to inspire other fields of study such as recommender systems, system biology, etc., which will in turn expand CI's scope and applications. As a comprehensive text, the book covers a range of key topics, including network community discovery, evolutionary optimization, network structure balance analytics, network robustness analytics, community-based personalized recommendation, influence maximization, and biological network alignment. Offering a rich blend of theory and practice, the book is suitable for students, researchers and practitioners interested in network analytics and computational intelligence, both as a textbook and as a reference work.

Fuzzy Cluster Analysis presents advanced and powerful fuzzy clustering techniques. This thorough and self-contained introduction to fuzzy clustering methods and applications covers classification, image recognition, data analysis and rule generation. Combining theoretical and practical perspectives, each method is analysed in detail and fully illustrated with examples. Features include:

• Sections on inducing fuzzy if-then rules by fuzzy clustering and non-alternating optimization fuzzy clustering algorithms
• Discussion of solid fuzzy clustering techniques like the fuzzy c-means, the Gustafson-Kessel and the Gath-and-Geva algorithm for classification problems
• Focus on linear and shell clustering techniques used for detecting contours in image analysis
• Accompanying software and data sets pertaining to the examples presented, enabling the reader to learn through experimentation
• Examination of the difficulties involved in evaluating the results of fuzzy cluster analysis and of determining the number of clusters with analysis of global and local validity measures
• Description of different fuzzy clustering techniques allowing the user to select the method most appropriate to a particular problem

The volume presents a selection of in-depth studies and state-of-the-art surveys of several challenging topics that are at the forefront of modern applied mathematics, mathematical modeling, and computational science. These three areas represent the foundation upon which the methodology of mathematical modeling and computational experiment is built as a ubiquitous tool in all areas of mathematical applications. This book covers both fundamental and applied research, ranging from studies of elliptic curves over finite fields with their applications to cryptography, to dynamic blocking problems, to random matrix theory with its innovative applications. The book provides the reader with state-of-the-art achievements in the development and application of new theories at the interface of applied mathematics, modeling, and computational science.

This book aims at fostering interdisciplinary collaborations required to meet the modern challenges of applied mathematics, modeling, and computational science. At the same time, the contributions combine rigorous mathematical and computational procedures and examples from applications ranging from engineering to life sciences, providing a rich ground for graduate student projects.

The book describes a systematic stochastic modeling approach for assessing thermal-fatigue crack-growth in mixing tees, based on the power spectral density of temperature fluctuation at the inner pipe surface. It shows the development of a frequency-temperature response function in the framework of single-input, single-output (SISO) methodology from random noise/signal theory under sinusoidal input. The frequency response of stress intensity factor (SIF) is obtained by a polynomial fitting procedure of thermal stress profiles at various instants of time. The method, which takes into account the variability of material properties, and has been implemented in a real-world application, estimates the probabilities of failure by considering a limit state function and Monte Carlo analysis, which are based on the proposed stochastic model. Written in a comprehensive and accessible style, this book presents a new and effective method for assessing thermal fatigue crack, and it is intended as a concise and practice-oriented guide for all undergraduate students, young scientists and researchers dealing with probabilistic assessment of structural integrity.

One of the most notable features of nanometer scale CMOS technology is the increasing magnitude of variability of the key device parameters affecting performance of integrated circuits. The growth of variability can be attributed to multiple factors, including the difficulty of manufacturing control, the emergence of new systematic variation-generating mechanisms, and most importantly, the increase in atomic-scale randomness, where device operation must be described as a stochastic process. In addition to wide-sense stationary stochastic device variability and temperature variation, existence of non-stationary stochastic electrical noise associated with fundamental processes in integrated-circuit devices represents an elementary limit on the performance of electronic circuits. In an attempt to address these issues, Stochastic Process Variation in Deep-Submicron CMOS: Circuits and Algorithms offers unique combination of mathematical treatment of random process variation, electrical noise and temperature and necessary circuit realizations for on-chip monitoring and performance calibration. The associated problems are addressed at various abstraction levels, i.e. circuit level, architecture level and system level. It therefore provides a broad view on the various solutions that have to be used and their possible combination in very effective complementary techniques for both analog/mixed-signal and digital circuits. The feasibility of the described algorithms and built-in circuitry has been verified by measurements from the silicon prototypes fabricated in standard 90 nm and 65 nm CMOS technology.

Rapid developments in multivariable spectral theory have led to important and fascinating results which also have applications in other mathematical disciplines. In this book, classical results from the cohomology theory of Banach algebras, multidimensional spectral theory, and complex analytic geometry have been freshly interpreted using the language of homological algebra. It has also been used to give in sights into new developments in the spectral theory of linear operators. Various concepts from function theory and complex analytic geometry are drawn together and used to give a new approach to concrete spectral computations. The advantages of this approach are illustrated by a variety of examples, unexpected applications, and conceptually new ideas which should stimulate further research.

This volume collects recent advances in nonlinear delay systems, with an emphasis on constructive generalized Lyapunov and predictive approaches that certify stability properties. The book is written by experts in the field and includes two chapters by Miroslav Krstic, to whom this volume is dedicated. This volume is suitable for all researchers in mathematics and engineering who deal with nonlinear delay control problems and students who would like to understand the current state of the art in the control of nonlinear delay systems.

This richly illustrated textbook explores the amazing interaction between combinatorics, geometry, number theory, and analysis which arises in the interplay between polyhedra and lattices. Highly accessible to advanced undergraduates, as well as beginning graduate students, this second edition is perfect for a capstone course, and adds two new chapters, many new exercises, and updated open problems. For scientists, this text can be utilized as a self-contained tooling device. The topics include a friendly invitation to Ehrhart's theory of counting lattice points in polytopes, finite Fourier analysis, the Frobenius coin-exchange problem, Dedekind sums, solid angles, Euler-Maclaurin summation for polytopes, computational geometry, magic squares, zonotopes, and more. With more than 300 exercises and open research problems, the reader is an active participant, carried through diverse but tightly woven mathematical fields that are inspired by an innocently elementary question: What are the relationships between the continuous volume of a polytope and its discrete volume? Reviews of the first edition: "You owe it to yourself to pick up a copy of Computing the Continuous Discretely to read about a number of interesting problems in geometry, number theory, and combinatorics." - MAA Reviews "The book is written as an accessible and engaging textbook, with many examples, historical notes, pithy quotes, commentary integrating the mate rial, exercises, open problems and an extensive bibliography." - Zentralblatt MATH "This beautiful book presents, at a level suitable for advanced undergraduates, a fairly complete introduction to the problem of counting lattice points inside a convex polyhedron." - Mathematical Reviews "Many departments recognize the need for capstone courses in which graduating students can see the tools they have acquired come together in some satisfying way. Beck and Robins have written the perfect text for such a course." - CHOICE

This book presents, in a consistent and unified overview, results and developments in the field of todays spherical sampling, particularly arising in mathematical geosciences. Although the book often refers to original contributions, the authors made them accessible to (graduate) students and scientists not only from mathematics but also from geosciences and geoengineering. Building a library of topics in spherical sampling theory it shows how advances in this theory lead to new discoveries in mathematical, geodetic, geophysical as well as other scientific branches like neuro-medicine. A must-to-read for everybody working in the area of spherical sampling.