Advancements and Technologies in Pig and Poultry Bacterial Disease Control provides the most up-to-date knowledge on the tools and technologies used in the economics, prevention, monitoring and control of the most important bacterial diseases in these two important livestock species. Written by international experts in veterinary medicine, veterinary science, agricultural economics and environmental monitoring, this book provides state-of-the-art information regarding the application of technology to the prevention and control of bacterial disease in pigs and poultry. It presents the most up-to-date information on the major bacterial pathogens, why they are important, their epidemiology, pathogenesis and molecular basis of their virulence. Additional sections examine how genomic sequencing addresses the development of disease biomarkers for faster and highly specific diagnosis and how next generation sequencing can identify good and bad microflora. This book will be a valuable resource for veterinarians, epidemiologists, animal scientists, technologists, and researchers studying precision livestock farming. Students in veterinary, animal science and bio-science courses will also find it useful for its coverage of diseases and monitoring tools.

Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth.

Progress in Genomic Medicine: From Research to Clinical Application provides a careful synthesis of the foundations, current trends and translational challenges in genomic medicine, clarifying pathways forward and enabling genomic medicine research and implementation across clinical settings and treatment development. Sections address the history and growth of genetic medicine, with a discussion of key studies in syndrome delineations, inherited diseases, biochemical genetics, and chromosome abnormalities, overview clinical applications made possible through genomic advances, with chapters on DNA sequencing for clinical genetic diagnosis, genotype-phenotype correlations in individuals and across populations, new-born screening for treatable genetic disorders, and more. In addition, social, ethical and public health aspects of applying genomic technologies are included throughout. Here, Dr. Smith applies her experience and participation in the field, across its major milestones, to put current research, clinical advances, and ongoing questions in context.

Advances in Insect Physiology, Volume 61 highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Acoustic signaling in Orthoptera, Sound production in Drosophila melanogaster, and Communication by surface borne mechanical waves in insects.

Advances in Microbial Physiology, Volume 79, the latest release in this serial that highlights new advances in the field, presents interesting and timely chapters authored by an international board of subject matter experts.

Modelling: The Oculomotor Systems, Volume 269 in the Progress in Brain Research serial highlights new advances in the field with this new volume presenting interesting chapters on topics including The function and phylogeny of eye movements, The behavior of motoneurons, Statics of plant mechanics, Dynamics of plant mechanics, The functional operation of the vestibulo-ocular reflex, Basic framework of the vestibulo-ocular reflex, Oculomotor signals, Signal processing in the vestibulo-ocular reflex, Plasticity and repair of the vestibulo-ocular reflex, The behavior of the optokinetic system, Models of the optokinetic system, Neurophysiology of the optokinetic system, and much more.

Molecular Mechanisms of Nutritional Interventions and Supplements for the Management of Sexual Disfunction and Benign Prostatic Hyperplasia presents the epidemiologic data linking diet with BPH and ED, along with a deep explanation on why nutritional approaches and different macronutrients may modify the pathogenesis of the disease. Coverage includes the relevance/epidemiology of the disease, pathophysiological events causing the disease, available therapeutic options, molecular mechanisms of action of available treatments, epidemiological and intervention studies suggesting the benefit of diet as therapeutic option for BPH and ED, and potential mechanisms of action of nutritional based approaches as treatment for BPH and ED. By combining medicine, diet and lifestyle options, this title provides a truly multidisciplinary approach to BPH and ED, making it a unique resource for those treating BPH and an irreplaceable reference guide for those in research.

Retinal Computation summarizes current progress in defining the computations performed by the retina, also including the synaptic and circuit mechanisms by which they are implemented. Each chapter focuses on a single retinal computation that includes the definition of the computation and its neuroethological purpose, along with the available information on its known and unknown neuronal mechanisms. All chapters contain end-of-chapter questions associated with a landmark paper, as well as programming exercises. This book is written for advanced graduate students, researchers and ophthalmologists interested in vision science or computational neuroscience of sensory systems. While the typical textbook's description of the retina is akin to a biological video camera, the real retina is actually the world's most complex image processing machine. As part of the central nervous system, the retina converts patterns of light at the input into a rich palette of representations at the output. The parallel streams of information in the optic nerve encode features like color, contrast, orientation of edges, and direction of motion. Image processing in the retina is undeniably complex, but as one of the most accessible parts of the central nervous system, the tools to study retinal circuits with unprecedented precision are up to the task. This book provides a practical guide and resource about the current state of the field of retinal computation. Editorial Reviews: "...this book is also a unique overview of our current understanding of the why and the how of retinal computation and there is something here for anyone with a grounding in vision science who recognises that there is more to what the retina does than... meets the eye." -- Prof Steven Dakin, New Zealand Optics, May 28, 2022. "I want to commend Dr. Schwartz for assembling this incredible resource and strongly recommend Retinal Computation to everyone who is a student of vision. The vast majority of modern topics in retina are covered yet in a fashion that is clear, and concise. The book covers the cellular and circuit basis of computations ranging from those covered by most textbooks, such as center-surround receptive field or direction selectivity , to those you probably do not associated with the retina such as "motion anticipation" and "threat detection". Each chapter is self-contained, meaning you can easily "pick and choose" the topics. A quick perusal of the chapter titles are almost certainly going to pique your interest. For example, you may know that the retina has single photon sensitivity but do you know "How many photons does it take to create a percept"? (Chapter 1). How does the retina encode texture (i.e. spatial fluctuations within the receptive field)? (Chapter 7). Is object motion sensitivity related to Direction selectivity? (Chapter 12). The list goes on. This book will also serve as a great resource for those teaching advanced undergraduate or graduate level vision courses for students with backgrounds in experimental or computational vision science. Each chapter contains what Dr. Schwartz's considers a "landmark paper" in the field, with a set of questions that can be used as a guide for reading these papers. And finally he includes programming exercises that can be easily implemented in Matlab to address basic concepts introduced in the chapter. The instructions are detailed so that even those new to Matlab will be able to implement these exercises these straightforward. It is this combination - textbook chapter + primary literature + quantitative exercises that will solidify these concepts. There are many vision science topics not covered in the book. For example, there is little on retinal disease or development. But these limitations are far outweighed by where the book succeeds. The vast majority of the book is written by Dr. Schwartz, giving it a uniformity that is welcome. Despite tackling quite modern questions where there is ongoing progress, Dr.Schwartz has extracted what are key findings that are likely to stand the test of time. And finally, it is really interesting! For those who think that the retina is "solved", think again. Retinal computations is a fantastic way for all circuit neuroscientist to learn how much computations can be achieved with very few synapses." -- Marla B. Feller, Ph. D., Paul Licht Distinguished Professor in Biological Sciences, Division of Neurobiology, Department of Molecular and Cell Biology & Helen Wills Neuroscience Institute University of California, Berkeley "This fantastic new textbook from a rising star in the field clearly and thoroughly updates our picture of what the retina computes. It is detailed enough for senior researchers but also pedagogical, providing a go-to reference for students. The illustrations within the text and for the chapter headings are both beautiful and informative." -- Stephanie E. Palmer, Ph.D., Associate Professor, Department of Organismal Biology and Anatomy, Department of Physics, University of Chicago "This book summarizes the impressive recent progress in understanding how visual computations are performed by retinal circuits. The book is an important resource not only for retinal experts, but more generally for anyone seeking to explain how the brain works at the level of neural circuits. Greg Schwartz and his co-authors have made a major contribution to the field." -- Sebastian Seung, Anthony B. Evnin '62 Professor, Neuroscience Institute and Computer Science Dept., Princeton University "This is a wonderful book from a true expert in the retina field. It is a fantastic resource for researchers, lecturers, and students alike. The book nicely covers the many facets of how the retina processes the visual input that enters the eye. Despite the richness in material, the presentation manages to stay accessible and always connects back to fundamental questions of visual processing. Each chapter by itself is a great entry point into a particular area of how the neural network of the retina deals with a specific set of visual challenges. I have thoroughly enjoyed this wonderful overview of retinal computation, served on a silver platter, and I will use the book both as background material for research and as a resource for teaching. I particularly like the sets of exercises that conclude each chapter." -- Dr. Tim Gollisch, Professor for Sensory Processing in the Retina, Department of Ophthalmology, University Medical Center Goettingen

Replication-Coupled Repair, Volume 661 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including the Repair of replication-born DNA breaks by sister chromatid recombination, High resolution and high throughput DNA cyclization measurements to interrogate DNA bendability, A programmable detection method for genomic signatures: from disease diagnosis to genome editing, Characterization of the telomerase modulating activities of yeast DNA helicases, Eukaryotic DNA replication with purified budding yeast proteins, Single molecule studies of yeast Rad51 paralogs, Light activation and deactivation of Cas9 for DNA repair studies, and more. Other chapters explore MIDAS: Direct sequencing to map mitotic DNA synthesis and common fragile sites at high precision, Studying the DNA damage response in embryonic systems, GLASS-ChIP to map Mre11 cleavage sites in the human genome, New chemical biology approaches to trap reaction intermediates in living cells, Single-molecule imaging approaches for monitoring replication fork conflicts at genomic DNA G4 structures and R-loops in human cells, Monitoring the replication of structured DNA through heritable epigenetic change, Visualizing replication fork encounters with DNA interstrand crosslinks, and much more.

Advances in Genetics, Volume 108 provides the latest information on genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of the topic. The book continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, with this new release including chapters on Clinical applications of cancer genetics and genomics, Epigenetic mutations in childhood tumors- the paradigm of Wilms tumor, Preventive population genomics-the model of BRCA related cancers, Recent advances of PARP inhibitors in medical oncology, Role of single cell and liquid biopsy in cancer research and clinical applications. Other chapters cover Recent advances and clinical utility of prostate cancer genomics, Recent advances in lung cancer genomics- applications in targeted therapy, and more.

Climate Change and Crop Stress: Molecules to Ecosystems expounds on the transitional period where science has progressed to 'post-genomics' and the gene editing era, putting field performance of crops to the forefront and challenging the production of practical applicability vs. theoretical possibility. Researchers have concentrated efforts on the effects of environmental stress conditions such as drought, heat, salinity, cold, or pathogen infection which can have a devastating impact on plant growth and yield. Designed to deliver information to combat stress both in isolation and through simultaneous crop stresses, this edited compilation provides a comprehensive view on the challenges and impacts of simultaneous stresses.

Advances in Applied Microbiology, Volume 117 continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas relating to the topic of microbiology.